Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

Abstract

Herbal remedies have been used for centuries to ameliorate complications of diabetes mellitus (DM). The aim of this study is to compare the effects of the oral curcumin supplement versus parenteral administration of turmeric extract on diabetic complications in a streptozocin (STZ) diabetic model. STZ DM rats received low and high doses turmeric extract intraperitoneally as well as oral curcumin. Curcumin and turmeric extracts significantly reduced blood glucose and creatinine levels, but not urea, and caused an increase in uric acid. Low dose improved liver enzymes, while higher dose and oral administration caused an increase in the ALT and AST. All groups showed an improvement in the serum cholesterol, while the triglycerides were not improved in the high and oral treatment. Histological evaluation showed islet cell protection. High‐dose injection showed almost intact renal corpuscles as well as tubular structures with minimal degeneration. Treatment showed limited protection of Liver tissue. Practical application Curcumin has been heavily marketed as a protective agent. The current study shows some potential risk of curcumin use. Oral and injectable curcumin should be used with caution. Turmeric extract and oral curcumin supplement showed protective effects on pancreatic, and renal structure and function. Although both did show some improvement in liver function, higher doses caused disturbance in liver enzymes and did not show histological evidence of liver tissue protection.

Hypoglycemic and antioxidant effects of five commercial turmeric ( Curcuma longa ) supplements

“…At least in part, this effect could be related to the positive correlation between the OSTT and glucose diffusion; as well as, to the negative correlation for α‐glucosidase. Additionally, our results are in agreement with studies showing that curcumin decreases glucose concentrations (Essa et al, 2019; Jaafari, Abnous, Mobarhan, & Oskuee, 2016; Xie, Wu, Shen, Li, & Wu, 2018).…”

Effect of adding turmeric powder to local buck rabbit’s rations on some production and blood traits

“…It has been showed that liver triacylglycerol and cholesterol concentrations were considerably less in rats fed curcumin than in control animals [36]. Relative growth rate = [(W2 -W1) x100]/ [1/2 (W2+W1)] Whereas: W1= the initial weight, and W2 = the final body weight Performance index = (final live body weight (kg)/ feed conversion ratio) x 100 [19].…”

“…And it has been found the effect to decrease the cholesterol level in humans [17] and in rabbits which suggested the role to manage the cardiovascular disease [12]. Furthermore, it has been indicated the beneficial role of turmeric extract in other diseases and disorders including obesity, diabetes and liver disease [18][19][20][21]; whereas to the anti-inflammatory effects the immune system [22][23][24]. So, this study investigates the effect of the inclusion of turmeric powder in diets on fattening rabbits and some blood biochemical traits.…”

Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

“…Thus, the therapeutic use of natural products with antioxidative and anti‐inflammatory potentials would be a good candidate for the treatment of diabetes and AD. Interestingly, the use of natural products, especially from plants in the management of diseases, has gained attention in recent times, partly because they are presumed to be less toxic, readily available, affordable, and with milder adverse side‐effects unlike synthetic drugs such as acarbose (Ekor, ; Essa et al, ).…”