A novel NIR-controlled NO release of sodium nitroprusside-doped Prussian blue nanoparticle for synergistic tumor treatment

Feng, Tao; Wan, Jingyuan; Li, Pan; Ran, Haitao; Chen, Huali; Wang, Zhigang; Zhang, Liangke

doi:10.1016/j.biomaterials.2019.05.024

Cited by 80 publications

(58 citation statements)

References 52 publications

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“…Moreover, codelivery of NO with chemotherapeutic drugs enhances the suppression of tumour growth [37][38][39][40] , and it is also discovered to enhance the efficacy of other treatments, such as photodynamic therapy [41][42][43] , radiotherapy 44,45 and ultrasound therapy 46,47 . However, NO has a half-life of only a few seconds in an aqueous environment, so NO release in specific targets is still a crucial challenge for antitumor therapy 48,49 . A wide range of NO donors have emerged as potential therapeutics to exploit the biological roles of NO [50][51][52][53][54][55] .…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

Jiao

Huang

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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A series of furoxan derivatives of chromone were prepared. The antiproliferative activities were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two normal human cell lines L-02 and PBMCs. Among them, compound 15a exhibited the most potent antiproliferative activity. It was also found 15a produced more than 8 mM of NO at the peak time of 45 min by Griess assay. Generally, antiproliferative activity is positively related to NO release to some extent. Further in-depth studies on apoptosis-related mechanisms showed that 15a caused S-phase cell cycle arrest in a concentrationdependent manner and induced apoptosis significantly through mitochondria-related pathways. Human apoptosis protein array assay also demonstrated 15a increased the expression levels of pro-apoptotic Bax, Bad, HtrA2 and Trail R2/DR5. The expression of catalase and cell cycle blocker claspin were similarly upregulated. In balance, 15a induced K562 cells death through both endogenous and exogenous pathways.

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Section: Introductionmentioning

confidence: 99%

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

Jiao

Huang

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…However, NO-based combination therapy has been extensively studied. Current ● NO-based treatment research mainly focuses on four pathways, including high concentration-induced cytotoxicity [ 127 ], as a chemotherapy sensitizer [ 128 ], as radiation therapy sensitizer [ 129 ], or as phototherapy sensitizer [ 120 , 122 ]. The ever-increasing antitumor research about the combination of ● NO therapy with various therapeutic strategies demonstrated the great significance of summarizing the related research works.…”

Section: Reactive Nitrogen Species-mediated Tumor Suppressionmentioning

confidence: 99%

Section: Reactive Nitrogen Species-mediated Tumor Suppressionmentioning

confidence: 99%

“…For example, Zhang and Feng have doped ● NO donor (sodium nitroprusside, SNP) into the mesoporous Prussian blue (m-PB) NPs to obtain m-PB-NO NPs, and then loading docetaxel (DTX) to construct the DTX@m-PB-NO platform ( Fig. 9 d) [ 127 ]. By adjusting the intensity and time of NIR light irradiation (808 nm), ● NO was released in a controlled manner.…”

Section: Reactive Nitrogen Species-mediated Tumor Suppressionmentioning

confidence: 99%

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Photoactivatable nanogenerators of reactive species for cancer therapy

Zheng

Jin

Liu

et al. 2021

Bioactive Materials

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In recent years, reactive species-based cancer therapies have attracted tremendous attention due to their simplicity, controllability, and effectiveness. Herein, we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy. First, we summarized the most widely explored reactive species, such as singlet oxygen, superoxide radical anion (O 2 ●- ), nitric oxide ( ● NO), carbon monoxide, alkyl radicals, and their corresponding secondary reactive species generated by interaction with other biological molecules. Then, we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation, followed by their anticancer effect, and the synergetic principles with other therapeutic modalities. This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.

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“…Furthermore, NO has been proved to be utilized as the assisted modality to enhance the other mainline therapeutic methods, such as PDT and radiotherapy. [13][14][15][16][17][18][19][20][21] The synergy of NO-based gas therapy and PDT successfully compensated for the poor therapeutic effect of photodynamic therapy under hypoxia. However, in vivo therapeutic application of NO is seriously challenged by the concentration-dependent killing efficacy and uncontrollable release of NO.…”

Section: Introductionmentioning

confidence: 99%

Multishell Nanoparticles with “Linkage Mechanism” for Thermal Responsive Photodynamic and Gas Synergistic Therapy

Zhu

Wang

et al. 2021

Adv Healthcare Materials

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The strategies of combining photodynamic therapy (PDT) with other therapeutics are considered to be the most suitable methods in improving the antitumor therapeutic efficiency. Herein, a "Linkage Mechanism" strategy based on thermal controllable multishell nanoparticles (CuS@SiO 2 -l-Arg (l-arginine)@PCM (phase-change material)-Ce6 (chiorin e6)) is proposed for combing PDT and NO-based gas therapy. Upon 1060 nm laser irradiation, the PCMs will melt under the photothermal effect induced by CuS and the loaded Ce6 and l-Arg can accurately release from the nanoparticles. Under further 660 nm laser irradiation, the released Ce6 will produce plenty of singlet oxygen ( 1 O 2 ) for PDT, while the generated 1 O 2 can oxidize l-Arg to release NO for the synergy of PDT and gas therapy. The "Linkage Mechanism" can achieve precise release of the payloads under the control of photothermal effect at tumor site, and the chain reaction of PDT and gas therapy overcomes the problem of premature release of gas during transportation. Benefiting from the guidance of fluorescence imaging and second near infrared photoacoustic imaging by Ce6 and CuS, both in vitro and in vivo experiments present effective antitumor efficiencies. The nanoparticles provide new ideas for controllable release of drugs and the synergistic effect of multiple treatments, possessing great application prospects.

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A novel NIR-controlled NO release of sodium nitroprusside-doped Prussian blue nanoparticle for synergistic tumor treatment

Cited by 80 publications

References 52 publications

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

Photoactivatable nanogenerators of reactive species for cancer therapy

Multishell Nanoparticles with “Linkage Mechanism” for Thermal Responsive Photodynamic and Gas Synergistic Therapy

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