Photoactivatable nanogenerators of reactive species for cancer therapy

Zheng, Xiaohua; Jin, Yilan; Liu, Xiao; Liu, Tianqing; Wang, Weiqi; Yu, Haijun

doi:10.1016/j.bioactmat.2021.04.030

Cited by 15 publications

(6 citation statements)

References 175 publications

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“…Li is widely used to store energy, particularly in batteries [ 265 , 266 , 267 , 268 ] and capacitors [ 269 , 270 ], and we foresee nanogenerators [ 271 ] (including stimuli-responsive nanogenerators, e.g., photoactivatable nanogenerators [ 272 ]) will have broad applications in medical fields, such as regenerative medicine, rehabilitation, and cancer treatment [ 273 , 274 , 275 , 276 ], particularly as nanogenerators have been shown to increase the efficacy of chemoimmunotherapy for non-small-cell lung cancer [ 277 ]. Therefore, Li-doped bioceramics may be good candidates for nanogenerators for advanced multifunctional systems in cancer treatments and regenerative medicine [ 272 , 278 ]. Li has anti-replication properties in viruses and is anti-mitotic in cancer cells, but it simultaneously stimulates stem cell proliferation, which may be an evolved regulatory system.…”

Section: Discussionmentioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

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Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

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Section: Discussionmentioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

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“…The merits of photosensitizer peptide-based nanostructures for PDT have greatly promoted their bio-application in many types of cancer cells [37,38]. However, most of the research to date has focused on evaluating cancer-cell biochemical processes during PDT.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled peptide nanoparticles for photodynamic therapy: morphological and mechanical effects on hepatocellular carcinoma cells

Guo,

Liu,

Dong

et al. 2023

Biomed. Mater.

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Self-assembling peptides, offering favorable biocompatibility, high stability, and easy incorporation of various functionalities, have demonstrated enormous potential for the precise design of next-generation nanodrugs for non-invasive tumor therapy. Peptide-based supramolecular photodynamic therapy (PDT) has shown great promise as an emerging modality for cancer treatment, achieving substantially-enhanced photosensitizer delivery selectivity and treatment efficacy, based on peptide biological activity and self-assembly potential. Although considerable research has been conducted toward fabricating self-assembling peptide-based smart nanodrugs for PDT, few studies have investigated cellular biophysical responses as indicators of tumor function and metabolic state. Here, via atomic force microscopy (AFM)-based morphological and mechanical measurements, including optical microscopy and scanning electron microscopy, we observed, for the first time, variation in membrane stiffness of human liver (HepG2) cancer cells treated with self-assembling peptides serving as a PDT nanodrug. This biophysical information will help to establish a comprehensive understanding of the anticancer effect of peptide-based smart nanodrugs, and highlight the exceptional ability of AFM in determining cell-surface properties.

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“…During PDT, photoactivated PSs transfer energy to surrounding molecular oxygen in the cells to generate highly reactive singlet oxygen ( 1 O 2 ) (type II reaction). In addition, PSs can transfer electrons to generate short-lived PS radical species (type I reaction) that subsequently produce a range of compounds called reactive oxygen species (ROS), such as superoxide anions and hydroxyl radicals [ 3 , 4 ]. An overload of ROS causes significant toxicity by oxidative stress, which eventually leads to cell death.…”

Section: Introductionmentioning

confidence: 99%

Autophagy Regulation Using Multimodal Chlorin e6-Loaded Polysilsesquioxane Nanoparticles to Improve Photodynamic Therapy

et al. 2023

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Photodynamic therapy (PDT) is a promising anticancer noninvasive technique that relies on the generation of reactive oxygen species (ROS). Unfortunately, PDT still has many limitations, including the resistance developed by cancer cells to the cytotoxic effect of ROS. Autophagy, which is a stress response mechanism, has been reported as a cellular pathway that reduces cell death following PDT. Recent studies have demonstrated that PDT in combination with other therapies can eliminate anticancer resistance. However, combination therapy is usually challenged by the differences in the pharmacokinetics of the drugs. Nanomaterials are excellent delivery systems for the efficient codelivery of two or more therapeutic agents. In this work, we report on the use of polysilsesquioxane (PSilQ) nanoparticles for the codelivery of chlorin-e6 (Ce6) and an autophagy inhibitor for early- or late-stage autophagy. Our results, obtained from a reactive oxygen species (ROS) generation assay and apoptosis and autophagy flux analyses, demonstrate that the reduced autophagy flux mediated by the combination approach afforded an increase in the phototherapeutic efficacy of Ce6-PSilQ nanoparticles. We envision that the promising results in the use of multimodal Ce6-PSilQ material as a codelivery system against cancer pave the way for its future application with other clinically relevant combinations.

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Photoactivatable nanogenerators of reactive species for cancer therapy

Cited by 15 publications

References 175 publications

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Self-assembled peptide nanoparticles for photodynamic therapy: morphological and mechanical effects on hepatocellular carcinoma cells

Autophagy Regulation Using Multimodal Chlorin e6-Loaded Polysilsesquioxane Nanoparticles to Improve Photodynamic Therapy

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