“…[6][7][8] Given this, the enzyme or enzyme-like catalysts, those can catalyze the decomposition of H 2 O 2 to produce reactive oxygen species (ROS), have been widely used in designing antibacterial patches, as the ROS has proven to be able to achieve the goal of non-resistant sterilization. [9][10][11][12] Nevertheless, the catalystsbased antibacterial patches still face four formidable challenges in accelerating the diabetic wound healing: (i) the limited local H 2 O 2 source severely limits the antibacterial effect and durability; 1,13,14 (ii) the diffusion distance of ROS is known to be extremely short, resulting in a significantly reduced antibacterial activity; 9 (iii) the hyperglycemia is the root cause of bacterial infection spread, the reported antibacterial patches without glucose-lowering function are difficult to fundamentally eliminate the risk of bacterial infection and spread; 2,13 (IV) the surface proteins expressed by different species of bacteria are quite different, thereby, even combined with aptamer modification technology, it is still a great challenge for enzyme/enzyme-like catalysts to realize precise and broad-spectrum sterilization. 4,9,10 Taken together, an advanced diabetic wound treatment strategy should hold potential to break the above-mentioned limitations.…”