Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)

Qian, Cheng; Xu, Meng; Sun, Chen; Yang, Kuikun; Yang, Zhiqing; Li, Junyan; Zheng, Jun; Zheng, Ying; Wang, Ruibing

doi:10.1039/d1mh01813b

Cited by 22 publications

(17 citation statements)

References 29 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inspired by the attractive chimeric antigen receptor macrophage (CAR-macrophage), Wang and co-workers put forward a reminiscent concept named supramolecular artificial receptor-modified macrophage (SAR-macrophage) by modifying macrophage with CB [7] on the surface by ligand (DSPE-PEG-CB [7]) insertion (Figure 9D). [72] SARmacropahge exhibited enhanced recognition and engulfment of bacteria tagged with a guest molecule (ADA). Both in vitro and in vivo results showed that SAR macrophage could dramatically enhance the identification and clearance of E. coli, through host-guest recognition and the subsequent polarization and reactive oxygen species (ROS) generation.…”

Section: Methodsmentioning

confidence: 99%

“…Inspired by the attractive chimeric antigen receptor macrophage (CAR‐macrophage), Wang and co‐workers put forward a reminiscent concept named supramolecular artificial receptor‐modified macrophage (SAR‐macrophage) by modifying macrophage with CB[7] on the surface by ligand (DSPE‐PEG‐CB[7]) insertion (Figure 9D) [72] . SAR‐macropahge exhibited enhanced recognition and engulfment of bacteria tagged with a guest molecule (ADA).…”

Section: Covalent Cb[n]‐based Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Cucurbituril‐Based Supramolecular Polymers for Biomedical Applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

Supramolecular polymers (SPs) have attracted broad interest because of their intriguing features and functions. Host-guest interactions often impart tunable physicochemical properties, reversible hierarchical organization, and stimuli-responsiveness to SPs for diverse biomedical applications. Characterized by strong but dynamic interactions with guest molecules, cucurbit[n]uril (CB[n]) has shown great potential as an important building block of various functional polymers for biomedical applications. In this Minireview, we summarize the most recent examples regarding the design, fabrication, and biomedical applications of CB[n]-based supramolecular polymers (CSPs), which are categorized as noncovalent and covalent CSPs according to the interactions between the CB[n] and polymer backbones. The design principles of CSPs and their unique advantages for biomedical applications, as well as the developmental trends and future perspectives of this cross-disciplinary area are also discussed.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Covalent Cb[n]‐based Polymersmentioning

confidence: 99%

Cucurbituril‐Based Supramolecular Polymers for Biomedical Applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The promoted recognition and capture of E. coli induced the M1 polarization of macrophages to generate ROS and effectively killed the intracellular bacteria. This work provides a supramolecular cell-engineering approach for potential antibacterial applications [ 108 ].…”

Section: Supramolecular Self-assembly For the Improvement Phagocytosi...mentioning

confidence: 99%

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Guo

Yuan-yuan

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

Antibiotic resistance has posed a great threat to human health. The emergence of antibiotic resistance has always outpaced the development of new antibiotics, and the investment in the development of new antibiotics is diminishing. Supramolecular self-assembly of the conventional antibacterial agents has been proved to be a promising and versatile strategy to tackle the serious problem of antibiotic resistance. In this review, the recent development of antibacterial agents based on supramolecular self-assembly strategies will be introduced.

show abstract

“…Cyclodextrins (CDs), a class of cyclic oligomers of glucose, with excellent biocompatibility, extreme non-immunogenicity, and low toxicity in vivo, are widely used in many pharmaceutical products. [24][25][26][27] Its special cavity structure can effectively protect the functional groups of payloads and enhance their water solubility. Using 2-methoxypropene (MP) as an engineering reagent, acetalated cyclodextrin materials (Ac-CD) with acid responsiveness can be facilely prepared.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin‐Derived ROS‐Generating Nanomedicine with pH‐Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy

Zha

Han

et al. 2022

Small

Self Cite

View full text Add to dashboard Cite

Nowadays, destruction of redox homeostasis to induce cancer cell death is an emerging anti‐cancer strategy. Here, the authors utilized pH‐sensitive acetalated β‐cyclodextrin (Ac‐β‐CD) to efficiently deliver dihydroartemisinin (DHA) for tumor ferroptosis therapy and chemodynamic therapy in a synergistic manner. The Ac‐β‐CD‐DHA based nanoparticles are coated by an iron‐containing polyphenol network. In response to the tumor microenvironment, Fe2+/Fe3+ can consume glutathione (GSH) and trigger the Fenton reaction in the presence of hydrogen peroxide (H2O2), leading to the generation of lethal reactive oxygen species (ROS). Meanwhile, the OO bridge bonds of DHA are also disintegrated to enable ferroptosis of cancer cells. Their results demonstrate that these nanoparticles acted as a ROS generator to break the redox balance of cancer cells, showing an effective anticancer efficacy, which is different from traditional approaches.

show abstract

Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)

Abstract: SAR-Macrophage was developed to rapidly recognize E. coli through strong host–guest interactions, thus improving the internalization of E. coli, which subsequently induced M1 polarization of macrophages to kill bacteria.

Cited by 22 publications

References 29 publications

Cucurbituril‐Based Supramolecular Polymers for Biomedical Applications

Cucurbituril‐Based Supramolecular Polymers for Biomedical Applications

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Cyclodextrin‐Derived ROS‐Generating Nanomedicine with pH‐Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy

Contact Info

Product

Resources

About