A self-powered and drug-free diabetic wound healing patch breaking hyperglycemia and low H<sub>2</sub>O<sub>2</sub>limitations and precisely sterilizing driven by electricity

Wang, Linlin; Su, Qiwen; Liu, Yi; Yimamumaimaiti, Tajiguli; Hu, Dandan; Zhu, Jun‐Jie; Zhang, Jian‐Rong

doi:10.1039/d2sc04242h

Cited by 11 publications

(7 citation statements)

References 33 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[85][86][87] Additionally, the generation of ROS has shown potential for nonresistant sterilization. [88] and the exposure of algae chlorophyll to lasers can synergistically produce ROS with the immune system to combat bacteria generated biofilms. [89]…”

Section: Oxygen or Hydrogen And Reactive Oxygen Species Productionmentioning

confidence: 99%

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Ma,

Fang,

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Diabetic chronic wounds (DCWs) are a severe complication of diabetes, and current treatments present several deficiencies, including unsatisfactory efficacy and inability to continuously supply oxygen. This review highlights the recent advances in a novel therapeutic strategy that addresses these challenges: considerable biological powerful inclusions, oxygen or hydrogen and ROS production, DCW glucose consumption, chemotaxis at the wound site, highly editable, great biological safety, low cost, and readily available. Over the past decade, this strategy has shown encouraging results in improving the healing delay induced by hyperglycemia, forming a new concept of “living material” application based on living algae. This review discusses the unique advantages of algae as a treatment strategy, the applications and characteristics of different types of living algae in wound dressings, and the challenges and improvement strategies for this innovative approach.

show abstract

Section: Oxygen or Hydrogen And Reactive Oxygen Species Productionmentioning

confidence: 99%

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Ma,

Fang,

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Essentially, an EBFC-SPB is a well-designed EBFC with a simple two-electrode structure, and thus it holds great potential for creating portable and miniaturized electrochemical biosensors [2][3][4][5][6]. In particular, the power source of an EBFC-SPB is the energy that the EBFC harvests from the bio-fluids, making EBFC-SPBs ideal online biosensors [7][8][9][10][11]. In addition, as enzymes are highly specific biocatalysts, the EBFC-SPB possesses outstanding antiinterference capability compared to traditional electrochemical biosensors [12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Miniaturized Microfluidic Electrochemical Biosensors Powered by Enzymatic Biofuel Cell

et al. 2023

Self Cite

View full text Add to dashboard Cite

Electrochemical biosensors, in which enzymatic biofuel cells simultaneously work as energy power and signal generators, have become a research hotspot. They display the merits of power self-support, a simplified structure, in vivo operational feasibility, online and timely monitoring, etc. Since the concept of enzymatic biofuel cell-powered biosensors (EBFC-SPBs) was first proposed, its applications in health monitoring have scored tremendous achievements. However, the creation and practical application of portable EBFC-SPBs are still impeded by the difficulty in their miniaturization. In recent years, the booming microfluidic technology has powerfully pushed forward the progress made in miniaturized and portable EBFC-SPBs. This brief review recalls and summarizes the achievements and progress made in miniaturized EBFC-SPBs. In addition, we also discuss the advantages and challenges that microfluidic and screen-printing technologies provide to wearable and disposable EBFC-SPBs.

show abstract

“…Glucose oxidase (Gox) is popular for in situ ROS generation, which can react with glucose to produce glucuronic acid and hydrogen peroxide (H 2 O 2 ). H 2 O 2 is expected to form • OH with stronger antibacterial properties. , Thus, many researchers dedicate themselves to Gox-based materials for diabetic wound healing. , These studies achieved wound surface sterilization through the production of • OH. Regrettably, the generated • OH may also attack normal cells, which is very unfavorable to cell proliferation and migration in the later stage of wound healing.…”

Section: Introductionmentioning

confidence: 99%

Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing

Tan,

Zeng,

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Slow healing of wounds induces great pain in diabetic patients. However, developing new approaches to promote diabetic wound healing is still one of the toughest challenges in the medical field. Here, we constructed a new double-layer hydrogel to effectively regulate reactive oxygen species (ROS) on the wound and promote diabetic wound healing. The inner layer contains glucose oxidase (Gox), ferrocene-modified quaternary ammonium chitosan (Fc-QCs), and poly(β-cyclodextrin) (Pβ-CD), which is used to generate hydroxyl radicals (•OH) for antibacterial in the early stage of wound healing and collapses gradually. The outer layer is composed of gelatin and dopamine. In the later stage of wound healing, the outer layer contacts the skin, which is beneficial for ROS clearance on the wound. Antibacterial, ROS scavenging, and wound healing experiments have shown that the double-layer hydrogel possesses two-stage ROS regulating properties for programmed diabetic wound healing. In conclusion, it will be one of the most potential dressings for treating diabetic wounds in the future.

show abstract

A self-powered and drug-free diabetic wound healing patch breaking hyperglycemia and low H₂O₂limitations and precisely sterilizing driven by electricity

Abstract: Accelerating the diabetes-related chronic wounds healing is a long-sought-after goal in diabetes management. However, the therapeutic strategies based on antibiotic or catalysts still face great challenges to break the limitations...

Cited by 11 publications

References 33 publications

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Miniaturized Microfluidic Electrochemical Biosensors Powered by Enzymatic Biofuel Cell

Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing

Contact Info

Product

Resources

About

A self-powered and drug-free diabetic wound healing patch breaking hyperglycemia and low H2O2limitations and precisely sterilizing driven by electricity

Abstract: Accelerating the diabetes-related chronic wounds healing is a long-sought-after goal in diabetes management. However, the therapeutic strategies based on antibiotic or catalysts still face great challenges to break the limitations...

Cited by 11 publications

References 33 publications

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Miniaturized Microfluidic Electrochemical Biosensors Powered by Enzymatic Biofuel Cell

Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing

Contact Info

Product

Resources

About

A self-powered and drug-free diabetic wound healing patch breaking hyperglycemia and low H₂O₂limitations and precisely sterilizing driven by electricity