A meta-analysis about the association between −1082G/A and −819C/T polymorphisms of IL-10 gene and risk of type 2 diabetes

Zhang, Fan; Yang, Yuan; Lv, Han; Qiu, Jingfu; Wang, Yang; Hu, Dayi; Skrip, Laura; Chen, Fangchun

doi:10.1016/j.humimm.2013.01.021

Cited by 10 publications

(11 citation statements)

References 29 publications

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“…14 However, the results of various studies have been inconsistent. 4,14 The aim of the present case-control study was to investigate the relationship between SNPs of the IL10 gene (À1082 G/A [rs1800896], À819 T/C [rs1800871] and À592 A/C [rs1800872]) and the risk of type 2 diabetes mellitus in a Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Bai¹,

Jing²,

Guo³

et al. 2014

J Int Med Res

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Objective: To investigate the relationship between the interleukin 10 (IL10) gene single nucleotide polymorphisms (SNP) À1082 G/A (rs1800896), À819 T/C (rs1800871) and À592 A/C (rs1800872) and risk of type 2 diabetes mellitus in a Chinese population. Methods: This case-control study recruited patients with type 2 diabetes mellitus and healthy control subjects. Genotyping of the À1082 G/A (rs1800896), À819 T/C (rs1800871) and À592 A/C (rs1800872) SNPs was conducted and genotype frequencies were compared between the two groups. Results: The study recruited 364 patients with type 2 diabetes mellitus and 677 healthy controls. Patients carrying the À1082 GG genotype had a significantly increased risk of type 2 diabetes mellitus (adjusted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.03, 2.68), as did those patients carrying the À592 AA genotype (adjusted OR 1.63, 95% CI 1.06, 2.53). Subjects carrying both the À1082 GA þ GG and À592 AC þ AA genotypes had a significantly increased risk of type 2 diabetes mellitus (adjusted OR 2.03, 95% CI 1.24, 3.15). Conclusions: The SNPs À1082G/A and À592 A/C increased the risk for type 2 diabetes mellitus, and could be potential targets for screening for the early detection of the risk of type 2 diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Bai¹,

Jing²,

Guo³

et al. 2014

J Int Med Res

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“…Several meta-analyses have been performed to assess the association between IL10-1082A/G polymorphism and DM risk [ 15 – 17 ]. However, no meta-analysis study evaluated the association between IL10-1082A/G polymorphism and DN risk.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10-1082A/G Polymorphism and Diabetic Nephropathy: A Meta-Analysis

Xia

Wang

et al. 2015

Med Sci Monit

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BackgroundStudies have assessed the association between Interleukin-10 (IL-10) -1082A/G polymorphism and diabetic nephropathy (DN) risk, but the results were inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between IL10-1082A/G polymorphism and DN risk.Material/MethodsAll relevant studies were searched by using PubMed and EMBASE. Data were extracted by 2 authors independently. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated.ResultsNine case-control studies with 4165 subjects were included in this meta-analysis. We found that IL10-1082A/G polymorphism was significantly associated with an increased DN risk (OR=1.21; 95% CI 1.07–1.37; P=0.002). In the subgroup analysis by race, both Caucasians and Asians with IL10-1082A/G polymorphism showed increased DN risk (OR=1.25; 95% CI 1.03–1.52; P=0.03 and OR=1.25; 95% CI 1.04–1.49; P=0.02), respectively. When we deleted the study without diabetes type, the result was not altered (OR=1.21; 95% CI 1.02–1.44; P=0.03). In the subgroup analysis by sample size, both studies with large sample size and studies with small sample size showed increased DN risk (OR=1.16; 95% CI 1.02–1.31; P=0.02 and OR=1.50; 95% CI 1.14–1.98; P=0.004), respectively.ConclusionsThis meta-analysis confirmed that IL10-1082A/G polymorphism might contribute to the susceptibility for DN.

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“…Although several studies and few meta-analyses have evaluated the association between IL-10 gene polymorphisms with the risk of development of T2DM in different ethnic populations, their results showed controversies and inconsistencies that might be due relatively small sample size, selection bias and ethnic difference ( Bai, H, et al, 2014 , Helaly, MA and Hatata, EZ, 2013 , Kung, WJ, et al, 2010 , Yin, YW, et al, 2012 , Li, J, et al, 2013 , Zhang, F, et al, 2013 , Mtiraoui, N, et al, 2009 ). Another issue of concern is the under-representation of African-based studies.…”

Section: Introductionmentioning

confidence: 99%

African vs. Caucasian and Asian difference for the association of interleukin-10 promotor polymorphisms with type 2 diabetes mellitus (a meta-analysis study)

2016

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BackgroundInterleukin-10 (IL-10) is a multifunctional regulatory cytokine that might be associated with increased risk of type 2 diabetes mellitus (T2DM). IL-10 gene polymorphisms have been reported to be associated with T2DM in several ethnic populations with controversial results.ObjectivesThis work is an updated meta-analysis aiming at the evaluation of the association between IL-10 gene polymorphisms: rs1800872 (− 592 C > A), rs1800896 (− 1082 A > G) and rs1800871 (− 819 C > T) with the risk of T2DM.MethodsAll available full text studies published up to July 2015 were included in this meta-analysis. Mainly Pubmed and Science Direct databases were searched for all eligible studies pertinent to testing the association between IL-10 gene polymorphisms with the susceptibility to T2DM. Further analyses of the pooled and stratified data in terms of individual polymorphic types and subject ethnicity were done and assessed using varied genetic models.ResultsFifteen case-control studies with a total of 26 comparisons (10 for IL-10 − 592 C > A rs1800872, 11 for IL-10 − 1082 A > G rs1800896 and 5 for IL-10 − 819 C > T rs1800871 polymorphisms) met our inclusion criteria. IL-10 − 1082 A > G polymorphism was the only one to show an association with T2DM in all pooled sample particularly among Asian and European (high frequency of the G allele) ethnic groups. On the other hand, IL-10 − 592 C > A and − 819 C > T were significantly associated with T2DM only among African subjects.ConclusionsThis meta-analysis demonstrated that IL-10 − 1082 A > G polymorphism was associated with increased risk of development of T2DM in total subjects no matter was their ethnic background, while both IL-10 − 592 C > A and − 819 C > T polymorphisms were associated with that risk only among African subjects.

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A meta-analysis about the association between −1082G/A and −819C/T polymorphisms of IL-10 gene and risk of type 2 diabetes

Cited by 10 publications

References 29 publications

Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Interleukin-10-1082A/G Polymorphism and Diabetic Nephropathy: A Meta-Analysis

African vs. Caucasian and Asian difference for the association of interleukin-10 promotor polymorphisms with type 2 diabetes mellitus (a meta-analysis study)

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