Interleukin-10-1082A/G Polymorphism and Diabetic Nephropathy: A Meta-Analysis

Xia, Peng; Xu, Jianming; Wang, Pengpeng; Zhou, Jinjin; Guo, Hong

doi:10.12659/msm.892972

Cited by 9 publications

(5 citation statements)

References 20 publications

(16 reference statements)

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“…[ 24 ] In recent years, various studies on DN from various aspects of the pathophysiology of the kidney have been performed to explore the genetic factors that cause the disease, and some genetic susceptibility genes related to DN have also been found, such as angiotensin-converting enzyme ( ACE ) gene, [ 25 ] aldose reductase ( AR ) gene, [ 26 ] glucose transporter gene, [ 27 ] and interleukin-10 ( IL-10 ). [ 28 ] Therefore, to explore the relationship between the pathogenesis of DN and genetic susceptibility and further effectively retard the progression of DN have become a solution desiderated problem in clinic.…”

Section: Discussionmentioning

confidence: 99%

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Zhuang¹,

Niu²,

Liu³

et al. 2018

Medicine

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The aim of the study was to explore the correlation between rs7903146 and rs290487 polymorphisms in transcription factor 7-like 2 (TCF7L2) gene and diabetic nephropathy (DN) in Chinese Han population.Polymerase chain reaction–restriction fragment length polymorphism was used to determine genotypes of TCF7L2 polymorphisms in 90 patients with DN and 96 diabetes patients without DN. The linkage disequilibrium (LD) and haplotype analysis were performed with haploview software. Hardy–Weinberg equilibrium was assessed in the control group based on the genotype distributions of TCF7L2 polymorphisms. The genotype, allele, and haplotype distribution differences between the case and control groups were analyzed by chi-squared test, and odds ratio (OR) and 95% confidence interval (CI) were used to indicate the relative risk of DN.People carrying TT genotype of rs7903146 were more easily to be attacked by DN than CC genotype carriers (P = .02, OR = 4.26, 95% CI = 1.12–16.24). Meanwhile, T allele also showed 1.85 times risk to suffer from DN compared with C allele (OR = 1.85, 95% CI = 1.02–3.10). However, there was no significant difference in genotypes and alleles frequencies of rs290487 between 2 groups. The strong LD existed between the 2 single nucleotide polymorphisms and haplotype T–T (rs7903146–rs290487) increased the susceptibility to DN (OR = 2.63, 95% CI = 1.31–5.25).TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to DN in Chinese Han population, but rs290487 is not. Additionally, haplotype is also a risk factor for DN.

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Section: Discussionmentioning

confidence: 99%

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Zhuang¹,

Niu²,

Liu³

et al. 2018

Medicine

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“…In individuals with long-standing T1DM and DKD, IL-10 levels are a better predictor of albuminuria than are glycaemic control, blood pressure control or diabetes duration 85 . Although findings are inconsistent, polymorphisms in IL-10 genes might confer susceptibility to DKD 86 .…”

Section: B Cells In Diabetic Kidney Diseasementioning

confidence: 99%

B cells in type 1 diabetes mellitus and diabetic kidney disease

2017

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Type 1 diabetes mellitus (T1DM) is an autoimmune disorder that affects an estimated 30 million people worldwide. It is characterized by the destruction of pancreatic β cells by the immune system, which leads to lifelong dependency on exogenous insulin and imposes an enormous burden on patients and health-care resources. T1DM is also associated with an increased risk of comorbidities, such as cardiovascular disease, retinopathy, and diabetic kidney disease (DKD), further contributing to the burden of this disease. Although T cells are largely considered to be responsible for β-cell destruction in T1DM, increasing evidence points towards a role for B cells in disease pathogenesis. B cell-depletion, for example, delays disease progression in patients with newly diagnosed T1DM. Loss of tolerance of islet antigen-reactive B cells occurs early in disease and numbers of pancreatic CD20 B cells correlate with β-cell loss. Although the importance of B cells in T1DM is increasingly apparent, exactly how these cells contribute to disease and its comorbidities, such as DKD, is not well understood. Here we discuss the role of B cells in the pathogenesis of T1DM and how these cells are activated during disease development. Finally, we speculate on how B cells might contribute to the development of DKD.

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“…IL-10 rs1800896 polymorphism G allele has been shown to cause higher IL-10 production [ 10 ], which may further lead to carcinogenesis. Some studies have illustrated that the IL-10 rs1800896 polymorphism was correlated with enhanced risk of nasopharyngeal carcinoma [ 25 ] and gastric cancer [ 26 ], diabetic nephropathy [ 27 ], and non-Hodgkin's lymphoma [ 28 ]. However, non significant correlation between the polymorphism and polycystic ovary syndrome [ 29 ], cervical cancer [ 30 ], periodontal diseases [ 31 ] has been revealed.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

et al. 2017

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BackgroundThe association of interleukin-10 rs1800896 polymorphism with head and neck cancer risk and its clinical stages has been investigated by many published studies, but the results remain inconsistent. Therefore, we conducted this meta-analysis for further investigation.ResultsSix case-control studies involving 1,781 head and neck cancer patients and 1,978 controls were yielded. The results indicated an association between rs1800896 polymorphism and increased head and neck risk [odds ratio (95%confidence interval) for G vs. A, GA vs. AA, GG vs. AA, GA+GG vs. AA, and GG vs. AA + GA were 1.63 (1.30–2.04), 3.17 (2.11–4.76), 1.63 (1.17–2.26), 1.73 (1.25–2.39), and 2.73 (1.82–4.09), respectively]. The subgroup analyses all obtained similar results with overall populations. The results of clinical stages yielded a non-significant association. No publication bias was detected.Materials and MethodsThe PubMed and Chinese National Knowledge Infrastructure databases were searched up to December 27, 2016. Two authors independently selected studies, extracted and analyzed the data using the RevMan 5 software. Either a fixed effect or a random effect model was used to estimate pooled odds ratio and its 95% confidence intervals.ConclusionsWe concluded that interleukin-10 rs1800896 polymorphism was significantly associated with head and neck cancer risk but not with the clinical stages thereof.

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Interleukin-10-1082A/G Polymorphism and Diabetic Nephropathy: A Meta-Analysis

Cited by 9 publications

References 20 publications

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

B cells in type 1 diabetes mellitus and diabetic kidney disease

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

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