African vs. Caucasian and Asian difference for the association of interleukin-10 promotor polymorphisms with type 2 diabetes mellitus (a meta-analysis study)

Abstract

BackgroundInterleukin-10 (IL-10) is a multifunctional regulatory cytokine that might be associated with increased risk of type 2 diabetes mellitus (T2DM). IL-10 gene polymorphisms have been reported to be associated with T2DM in several ethnic populations with controversial results.ObjectivesThis work is an updated meta-analysis aiming at the evaluation of the association between IL-10 gene polymorphisms: rs1800872 (− 592 C > A), rs1800896 (− 1082 A > G) and rs1800871 (− 819 C > T) with the risk of T2DM.MethodsAll available full text studies published up to July 2015 were included in this meta-analysis. Mainly Pubmed and Science Direct databases were searched for all eligible studies pertinent to testing the association between IL-10 gene polymorphisms with the susceptibility to T2DM. Further analyses of the pooled and stratified data in terms of individual polymorphic types and subject ethnicity were done and assessed using varied genetic models.ResultsFifteen case-control studies with a total of 26 comparisons (10 for IL-10 − 592 C > A rs1800872, 11 for IL-10 − 1082 A > G rs1800896 and 5 for IL-10 − 819 C > T rs1800871 polymorphisms) met our inclusion criteria. IL-10 − 1082 A > G polymorphism was the only one to show an association with T2DM in all pooled sample particularly among Asian and European (high frequency of the G allele) ethnic groups. On the other hand, IL-10 − 592 C > A and − 819 C > T were significantly associated with T2DM only among African subjects.ConclusionsThis meta-analysis demonstrated that IL-10 − 1082 A > G polymorphism was associated with increased risk of development of T2DM in total subjects no matter was their ethnic background, while both IL-10 − 592 C > A and − 819 C > T polymorphisms were associated with that risk only among African subjects.

Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes

“…This polymorphism has been reported to be associated with type 2 diabetes [14], renovascular disease [15], and clinical outcomes in endstage renal disease [16]. We recently showed that the -1082A>G polymorphism is associated with diabetic retinopathy in type 2 diabetic patients (unpublished data).…”

Genetic Contributions of Inflammation to Depression

“…The -174 G allele of the IL-6 gene has been associated with the development of the metabolic syndrome and diabetes (Huth et al , 2006) as well as atherosclerosis (Chumaeva et al , 2014) in the context of chronic stress. The A allele of the -1082 polymorphism of the IL-10 gene has been associated with insulin resistance and obesity (Tarabay et al , 2016). MCP1 is considered to be a major attractant for macrophages in obesity, and the A allele of the G-2518 polymorphism is also associated with increased risk of diabetes and its complications (Zhang et al , 2011).…”

Polymorphism of the IL-10 gene in Azeri population of Iran

“…According to studies, people with the AA genotype and the A allele have a higher susceptibility to juvenile idiopathic arthritis (JIA) [34], asthma [35], ischemic stroke [36] and Alzheimer [37] than people with the GG genotype. Conversely, in comparison with the AA and AG genotypes, the GG genotype of the IL-10 -1082 predisposes individuals to hepatitis B virus (HBV), hepatitis C virus (HCV) [38], acute pancreatitis [13] and type 2 diabetes [39]. In contrast in a study, type 2 diabetes was more common in people with homozygous AA and GG genotypes and the AG genotype was more prevalent in controls.…”