Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Abstract

Objective: To investigate the relationship between the interleukin 10 (IL10) gene single nucleotide polymorphisms (SNP) À1082 G/A (rs1800896), À819 T/C (rs1800871) and À592 A/C (rs1800872) and risk of type 2 diabetes mellitus in a Chinese population. Methods: This case-control study recruited patients with type 2 diabetes mellitus and healthy control subjects. Genotyping of the À1082 G/A (rs1800896), À819 T/C (rs1800871) and À592 A/C (rs1800872) SNPs was conducted and genotype frequencies were compared between the two groups. Results: The study recruited 364 patients with type 2 diabetes mellitus and 677 healthy controls. Patients carrying the À1082 GG genotype had a significantly increased risk of type 2 diabetes mellitus (adjusted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.03, 2.68), as did those patients carrying the À592 AA genotype (adjusted OR 1.63, 95% CI 1.06, 2.53). Subjects carrying both the À1082 GA þ GG and À592 AC þ AA genotypes had a significantly increased risk of type 2 diabetes mellitus (adjusted OR 2.03, 95% CI 1.24, 3.15). Conclusions: The SNPs À1082G/A and À592 A/C increased the risk for type 2 diabetes mellitus, and could be potential targets for screening for the early detection of the risk of type 2 diabetes mellitus.

IL-6, TNF-α, and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazilian individuals

“…Additionally, a case-control study conducted by Bai and cols. (34) found higher risk for T2DM development associated with -1082 GA+GG and -592 AC+AA genotypes. These conflicting results are probably related to the sample size and different genetic background of the populations.…”

“…Some studies have investigated the association among TNF-α, IL-6, and IL-10 gene polymorphisms with metabolic diseases (17)(18)(19)(20)(21)(22)(23)(24)(25). Despite these reports examining the association of inflammation markers and SNPs in cytokine genes, much controversy remains as to their role in diabetes occurrence (26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population

“…Amre et al (2009) conducted a study on 270 patients with Crohn's disease and 336 control subjects, and reported that IL-10 -819C/T variants contributed to the onset of Crohn's disease. Several studies have reported the possible correlation between polymorphisms in IL-10 and the onset of type 2 diabetes mellitus, but with conflicting results (Ezzidi et al, 2009;Saxena et al, 2012Saxena et al, , 2013Yin et al, 2013;Bai et al, 2014;Chang et al, 2005). Chang et al (2005) reported that IL-10 polymorphisms could determine diabetic susceptibility in a Taiwanese population.…”

“…Furthermore, Saxena et al (2012Saxena et al ( , 2013 reported that Indian patients harboring the IL-10 -592C/A polymorphism displayed a greater risk of developing type 2 diabetes mellitus compared to that by the controls. Bai et al (2014) reported that the IL-10 -592C/A and -1082G/A polymorphisms increased the risk of type 2 diabetes mellitus in a Chinese population. A recent meta-analysis comprising 10 studies indicated that only the IL-10 -1082G/A polymorphism contributed to the onset of type 2 diabetes mellitus, while the IL-10 -819C/T and -592C/A polymorphisms did not (Hua et al, 2013).…”

“…Three single nucleotide polymorphisms in the promoter region of IL-10 [-1082G/A (rs1800896), -819C/T (rs1800871), and -592C/ A (rs1800872)] have been previously shown to alter the structure and expression of IL-10 by affecting the gene function (Glocker et al, 2011). Previous studies also reported that polymorphisms in IL-10 are associated with the development of type 2 diabetes mellitus, but with conflicting results (Saxena et al, 2012(Saxena et al, , 2013Zhang et al, 2013;Bai et al, 2014). In this case-control study, we investigated the relationship between the IL-10 -1082G/A, -819C/T, and -592C/A polymorphisms and pathogenesis of type 2 diabetes mellitus in a Chinese population.…”