Association between diabetic retinopathy and polymorphisms of cytokine genes: a systematic review and meta-analysis

Jafarzadeh, Faria; Javanbakht, Amin; bakhtar, Niloofar; Dalvand, Alaleh; Shabani, Mahya; Mehrabinejad, Mohammad-Mehdi

doi:10.1007/s10792-021-02011-9

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…At this point DR is classified as PDP [16,22,23] (Figure 1). Different sight-threatening factors have been identified as potential triggers of DR. For example, genetic data has identified polymorphisms in different genes as potential risk factors for the susceptibility to DR [24][25][26][27]. In addition, several types of experimental data indicate that oxidative stress, the excessive accumulation of reactive oxygen species (ROS), contribute to the onset and development of DR.…”

Section: Pathophysiological Mechanisms Underlying Diabetic Retinopathymentioning

confidence: 99%

Early Neural Changes as Underlying Pathophysiological Mechanism in Diabetic Retinopathy

Cantó

Martínez-González

Perini-Villanueva

et al. 2021

IJTM

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Diabetes mellitus is a chronic disease often accompanied by diabetic retinopathy (DR), one of the most common diabetic complications. DR is an eye condition that causes vision deficiency and often leads to blindness. DR develops when blood vessels damage the retina, the light-sensitive tissue at the back of the eye. Before changes in retinal blood vessel permeability, different molecular and anatomical modifications take place in the retina, including early neural changes. This review will summarize the current status of knowledge regarding pathophysiological mechanisms underlying DR, with a special focus on early neural modifications associated with DR. We describe hyperglycemia-associated molecular and cellular alterations linked to the initiation and progression of DR. We also discuss retinal neurodegeneration as a shared feature in different in vitro and in vivo models of DR. Given how ubiquitous diabetes is and how severe the effects of DR are, we also examine the current pharmacological and genetic approaches for combatting this disease.

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Section: Pathophysiological Mechanisms Underlying Diabetic Retinopathymentioning

confidence: 99%

Early Neural Changes as Underlying Pathophysiological Mechanism in Diabetic Retinopathy

Cantó

Martínez-González

Perini-Villanueva

et al. 2021

IJTM

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“…An upward trend in the incidence rate among the Iranian population suggests 9.2 million diabetes patients by 2030 [2][3][4][5]. Type 2 diabetes (T2D) has high morbidity and mortality rates (fifth leading cause of death in the Iranian population) [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Association Between Glycemic Control Status and Serum Level of Vitamin D3 in Patients with Type 2 Diabetes: A Cross-Sectional Study

Aliniagerdroudbari

Farhangian

Babaniamansour

et al. 2022

Clinical Diabetology

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Objective: This study aimed to assess the association between glycemic control status and serum levels of vitamin D3 in Iranian patients with type 2 diabetes (T2D). Materials and methods: This was a cross-sectional study on 452 patients with T2D in Tehran, Iran, performed between September 2019 and September 2020. We assessed the diabetes laboratory test and vitamin D3 level in all participants using the Enzymatic Glucose Oxidase method. Data were analyzed using SPSS version 24. Results: a total of 452 patients were enrolled in this study (mean age: 59.4 ± 11.4 years, 63.5% females). Vitamin D deficiency was reported in half of the participants. Deficient vitamin D was significantly associated with higher mean level of hemoglobin A1c, fasting plasma glucose, total cholesterol, and low-density lipoprotein-cholesterol (p < 0.05). Multiple regression showed that the level of vitamin D3 could be a good predictor of hemoglobin A1c after adjusting for confounding variables affecting the hemoglobin A1c (regression coefficient: 0.442, 95% CI, 0.072-0.811, p = 0.063). Conclusions: With the alarming rates of vitamin D deficiency in patients with T2D, there was a significant direct association between vitamin D3 and hemoglobin A1c levels before and after adjusting for the associated

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Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression

Ishiguro,

Ushiki,

Honda

et al. 2024

iScience

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Association between diabetic retinopathy and polymorphisms of cytokine genes: a systematic review and meta-analysis

Cited by 5 publications

References 51 publications

Early Neural Changes as Underlying Pathophysiological Mechanism in Diabetic Retinopathy

Early Neural Changes as Underlying Pathophysiological Mechanism in Diabetic Retinopathy

Association Between Glycemic Control Status and Serum Level of Vitamin D3 in Patients with Type 2 Diabetes: A Cross-Sectional Study

Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression

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