A fluorescence resonance energy transfer biosensor based on carbon dots and gold nanoparticles for the detection of trypsin

Xu, Shaomei; Zhang, Fangmei; Xu, Longbin; Liu, Xin; Ma, Pinyi; Sun, Ying; Wang, Xinghua; Song, Daqian

doi:10.1016/j.snb.2018.07.023

Cited by 69 publications

(26 citation statements)

References 38 publications

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“…Quantum dots (QDs) and AuNPs are the most commonly used FRET pairs in uorescence-based optical biosensors due to the overlapping of AuNPs' absorption spectrum with QDs' emission spectrum. [128][129][130] But the applicability of QD-based FRET biosensors is limited by their high cost, toxicity, the strong dependence of performance on surface states and chemical instability. 131 Metal nanoparticles or metal-doped nanoparticles are emerging as new alternatives of QDs in FRET-based biosensors.…”

Section: Optical Biosensors Based On Aunp Luminescencementioning

confidence: 99%

Gold nanomaterials for optical biosensing and bioimaging

et al. 2021

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Section: Optical Biosensors Based On Aunp Luminescencementioning

confidence: 99%

Gold nanomaterials for optical biosensing and bioimaging

et al. 2021

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“…The proposed sensing system was testified to show highly effective detection of human serum trypsin with broad trypsin concentration range (2.5–80 ng mL −1 ) and low detection limit (0.84 ng mL −1 ) as well as desirable sensitivity and selectivity, implying huge application potential for the quantification of trypsin in disease diagnosis. [ 188 ]…”

Section: Biomedical Applications Of Peptide‐engineered Fluorescent Namentioning

confidence: 99%

Peptide‐Engineered Fluorescent Nanomaterials: Structure Design, Function Tailoring, and Biomedical Applications

Wang

Xia

Wang

et al. 2021

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Fluorescent nanomaterials have exhibited promising applications in biomedical and tissue engineering fields. To improve the properties and expand bioapplications of fluorescent nanomaterials, various functionalization and biomodification strategies have been utilized to engineer the structure and function of fluorescent nanomaterials. Due to their high biocompatibility, satisfied bioactivity, unique biomimetic function, easy structural tailoring, and controlled self‐assembly ability, supramolecular peptides are widely used as versatile modification agents and nanoscale building blocks for engineering fluorescent nanomaterials. In this work, recent advance in the synthesis, structure, function, and biomedical applications of peptide‐engineered fluorescent nanomaterials is presented. Firstly, the types of different fluorescent nanomaterials are introduced. Then, potential strategies for the preparation of peptide‐engineered fluorescent nanomaterials via templated synthesis, bioinspired conjugation, and peptide assembly‐assisted synthesis are discussed. After that, the unique structure and functions through the peptide conjugation with fluorescent nanomaterials are demonstrated. Finally, the biomedical applications of peptide‐engineered fluorescent nanomaterials in bioimaging, disease diagnostics and therapy, drug delivery, tissue engineering, antimicrobial test, and biosensing are presented and discussed in detail. It is helpful for readers to understand the peptide‐based conjugation and bioinspired synthesis of fluorescent nanomaterials, and to design and synthesize novel hybrid bionanomaterials with special structures and improved functions for advanced applications.

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“…The peptide functionalized NPs have been extensively employed to construct biosensors/assays with various detection principles for detection of different analytes (some typical examples are included in Table 1 ) [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ,…”

Section: Biosensing Platforms Based On Peptide Functionalized Nanoparticlesmentioning

confidence: 99%

The Peptide Functionalized Inorganic Nanoparticles for Cancer-Related Bioanalytical and Biomedical Applications

Jian

Sun

et al. 2021

Molecules

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In order to improve their bioapplications, inorganic nanoparticles (NPs) are usually functionalized with specific biomolecules. Peptides with short amino acid sequences have attracted great attention in the NP functionalization since they are easy to be synthesized on a large scale by the automatic synthesizer and can integrate various functionalities including specific biorecognition and therapeutic function into one sequence. Conjugation of peptides with NPs can generate novel theranostic/drug delivery nanosystems with active tumor targeting ability and efficient nanosensing platforms for sensitive detection of various analytes, such as heavy metallic ions and biomarkers. Massive studies demonstrate that applications of the peptide–NP bioconjugates can help to achieve the precise diagnosis and therapy of diseases. In particular, the peptide–NP bioconjugates show tremendous potential for development of effective anti-tumor nanomedicines. This review provides an overview of the effects of properties of peptide functionalized NPs on precise diagnostics and therapy of cancers through summarizing the recent publications on the applications of peptide–NP bioconjugates for biomarkers (antigens and enzymes) and carcinogens (e.g., heavy metallic ions) detection, drug delivery, and imaging-guided therapy. The current challenges and future prospects of the subject are also discussed.

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A fluorescence resonance energy transfer biosensor based on carbon dots and gold nanoparticles for the detection of trypsin

Cited by 69 publications

References 38 publications

Gold nanomaterials for optical biosensing and bioimaging

Gold nanomaterials for optical biosensing and bioimaging

Peptide‐Engineered Fluorescent Nanomaterials: Structure Design, Function Tailoring, and Biomedical Applications

The Peptide Functionalized Inorganic Nanoparticles for Cancer-Related Bioanalytical and Biomedical Applications

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