Peptide‐Engineered Fluorescent Nanomaterials: Structure Design, Function Tailoring, and Biomedical Applications

Wang, Yan; Xia, Kai; Wang, Luchen; Wu, Ming‐Xue; X, Sang; Wan, Keming; Zhang, Xiaodong; Liu, Xiaomin; Wei, Gang

doi:10.1002/smll.202005578

Cited by 38 publications

(24 citation statements)

References 192 publications

(191 reference statements)

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“…Pt NCs, similar to noble metal clusters such as GNCs, are relatively stable molecular aggregates composed of up to hundreds of metal atoms 113 . Their physical size is normally between atoms and nanoparticles, close to the Fermi wavelength of a single electron.…”

Section: Pt Nanoclusters (Pt Ncs) As a New Pt Drug For Cancer Therapymentioning

confidence: 99%

“…Targeting peptides have widely been used to synthesize Pt NCs 24 , 113 , 122 , 123 , improving the existing first-line platinum drugs in the clinic that inhibit rapid proliferation of tumor cells, and can also improve drug bioavailability. For example, Feng et al synthesized mitochondria-targeting Pt NCs (CytcApt-Pt NCs) using cytochrome c aptamer (CytcApt) as a template.…”

Section: Pt Nanoclusters (Pt Ncs) As a New Pt Drug For Cancer Therapymentioning

confidence: 99%

See 1 more Smart Citation

Platinum-based drugs for cancer therapy and anti-tumor strategies

Zhang¹,

Xu²,

Gao³

et al. 2022

Theranostics

349

175

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Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, such as lack of selectivity, high systemic toxicity, and drug resistance, seriously limit their clinical application. With advancements in nanotechnology and chemical synthesis, Pt-based anti-cancer drugs have made great progress in cancer therapy in recent years. Many strategies relied on the anti-cancer mechanism similar to cisplatin and achieved some success by modifying existing platinum drugs. Pt-based nanodrugs, such as platinum nanoclusters, have novel anti-cancer mechanisms and great potential in tumor-targeted therapy and have shown promising results in clinical application. In this review, we systematically explored the development of first-line platinum chemotherapy drugs in the clinic and their anti-cancer mechanisms. We also summarize the progress of Pt-based anti-cancer drug application in cancer therapy, emphasizing their modification to enhance the anti-tumor effect. Finally, we address challenges faced by platinum chemotherapy drugs, especially Pt nanocluster-based nanodrugs, in cancer treatment. The new platinum drugs and their targeted modifications undoubtedly provide a promising prospect for improving the current anti-cancer treatments.

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Section: Pt Nanoclusters (Pt Ncs) As a New Pt Drug For Cancer Therapymentioning

confidence: 99%

Section: Pt Nanoclusters (Pt Ncs) As a New Pt Drug For Cancer Therapymentioning

confidence: 99%

Platinum-based drugs for cancer therapy and anti-tumor strategies

Zhang¹,

Xu²,

Gao³

et al. 2022

Theranostics

349

175

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“…Peptides containing several reactive sequences or amino acids, indeed, can provide NCs with different simultaneous functional properties, such as selective targeting abilities, or pH responsiveness [52]. For these reasons, the conjugation of peptides to metal NCs represents a viable strategy to create hybrid imaging platforms with improved selectivity, biocompatibility, and target binding ability, which are all highly required skills for biomedical applications [53,54].…”

Section: Peptidesmentioning

confidence: 99%

Photoluminescent nanocluster-based probes for bioimaging applications

Bergamaschi

Metrangolo

Dichiarante

2022

Photochem Photobiol Sci

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In the continuous search for versatile and better performing probes for optical bioimaging and biosensing applications, many research efforts have focused on the design and optimization of photoluminescent metal nanoclusters. They consist of a metal core composed by a small number of atoms (diameter < 2-3 nm), usually coated by a shell of stabilizing ligands of different nature, and are characterized by molecule-like quantization of electronic states, resulting in discrete and tunable optical transitions in the UV-Vis and NIR spectral regions. Recent advances in their size-selective synthesis and tailored surface functionalization have allowed the effective combination of nanoclusters and biologically relevant molecules into hybrid platforms, that hold a large potential for bioimaging purposes, as well as for the detection and tracking of specific markers of biological processes or diseases. Here, we will present an overview of the latest combined imaging or sensing nanocluster-based systems reported in the literature, classified according to the different families of coating ligands (namely, peptides, proteins, nucleic acids, and biocompatible polymers), highlighting for each of them the possible applications in the biomedical field.

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“…Nanomaterials have shown their promising performance in optics, electricity, biomedical and other science. [1][2][3] For deviceization, most of the envisioned applications should restrict nano materials in appropriate substrates with a concentration as high as possible rather than in solutions. [4] Only when the condition that nanomaterials are uniformly dispersed in "carbon dots-functionalized silanes" due to synchronously possess fluorescence property from CDs and coupling property from silane coupling agents (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Silane‐Functionalized Carbon Dots and Their Polymerized Hybrids: From Optoelectronics to Biotherapy

Dong

Wang

Guan

et al. 2021

Small

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matrices can show their unique intrinsic features. [5][6][7] Many hybrid composites and devices with excellent performance often require high doping concentration of functional materials. However, high doping ratio tends to result in adverse effects such as dropped transmittance caused by Rayleigh scattering, [8] weakened optoelectronic and mechanical performance. [9,10] Therefore, maintaining the intrinsic properties of nanoparticles while improving the doping concentration of nanomaterials becomes an urgent subject. There are two approaches to limit nanomaterials in substrates: physical dispersion and chemical dispersion. Physical dispersion of guest materials in host matrices is a conventional approach to prepare hybrid composites. Due to the weak physical interaction, the performance usually is impaired. Compared with physical dispersion, the covalent bond can prevent the phase separation existing in hybrid materials. [11] Among these ways, sol-gel method is a helpful technique to modify nanomaterials and prepare nano-or macroscale organic-inorganic hybrid materials such as glasses, ceramics, films, coatings, fibers, and powders. [12] Silane coupling agents or organosilicon polymers (silicone oil, resin, rubber, etc.) are introduced in the route based on the advantages of simultaneously possessing hydrophilic and lipophilic groups. First, they can elevate the dispersibility of nanomaterials in solutions. Second, they successfully link organic and inorganic phases with covalent bonds. Third, the introduction of silicon promotes the radiation recombination of electron/hole pairs through providing different surface states. There are five empty d orbitals of a silicon atom, where can be occupied by electrons of connected atoms or functional groups to form a dπ-pπ bond. [13] Owing to the above features, the hybrid materials inherit the superiorities of organosilanes: excellent resistance against high temperature; [14] stability under UV radiation; [15] lower surface tension, lower surface energy, and more prominent film-forming ability. [13] Since the discovery in 2004, carbon dots (CDs) have become promising issues due to their outstanding optical properties, such as high quantum yield (QY), photobleaching resistance, upconversion photoluminescence (PL). [16][17][18][19][20] In previous works, a concept of one-step prefunctionalization was brought up, using citric acid and long-chain amino-silanes as starting materials to prepare silane-functionalized CDs (SiCDs). [18] These types of CDs represent either "silane-functionalized carbon dots" or Nanomaterials usually manifest unique properties in solutions but will be undermined in the solid state. It is necessary to incorporate them into substrates or hybrid them with other functional materials for multiple devices and applications. Though there are a variety of methods to inherit their intrinsic properties like fluorescent and mechanical performance, most nanohybrid materials would lose their transparency irreversibly when construct solid-state devices. As a hot t...

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Peptide‐Engineered Fluorescent Nanomaterials: Structure Design, Function Tailoring, and Biomedical Applications

Cited by 38 publications

References 192 publications

Platinum-based drugs for cancer therapy and anti-tumor strategies

Platinum-based drugs for cancer therapy and anti-tumor strategies

Photoluminescent nanocluster-based probes for bioimaging applications

Silane‐Functionalized Carbon Dots and Their Polymerized Hybrids: From Optoelectronics to Biotherapy

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