A case of acrodermatitis continua of Hallopeau evolving into generalized pustular psoriasis successfully treated with guselkumab

Yamamoto, Hiroki; Okada, Hirofumi; Maekawa, Takeo; Komine, Mayumi; Ohtsuki, Mamitaro

doi:10.1111/ijd.16153

Cited by 7 publications

(8 citation statements)

References 5 publications

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“…Table 2 summarises details of case reports of ACH with GPP. 6,7,[50][51][52] Females predominate and ACH can occur before or after GPP. Interestingly, the onset of GPP after ACH ranged from 3 to 20 years.…”

Section: Ach Evolving Into Gpp and Ach With Gppmentioning

confidence: 99%

“…Table 2 summarises details of case reports of ACH with GPP. 6,7,[50][51][52] Females predominate and ACH can occur before or after GPP.…”

Section: Ach Alone and Predominate Achmentioning

confidence: 99%

“…GPP developed within 2 years after the onset of ACH. Table 2 summarises details of case reports of ACH with GPP 6,7,50–52 . Females predominate and ACH can occur before or after GPP.…”

Section: Introductionmentioning

confidence: 99%

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Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?

Chularojanamontri

Rattanakorn

Julanon

et al. 2023

Experimental Dermatology

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Acrodermatitis continua of Hallopeau (ACH) is a very rare, chronic and recurrent, inflammatory pustular eruption of the nail apparatus.It has also been called acrodermatitis continua suppurativa, pustular acrodermatitis, acrodermatitis perstans, dermatitis perstans and dermatitis repens. [1][2][3][4] Clinical characteristics are tender, sterile pustules on an inflamed, based on the tip of a digit, more frequently occurring on a finger than a toe. One or more digits can be affected which often leads to onychodystrophy and eventually anonychia.Rarely, osteitis resulting in osteolytic or bone resorption of the underlying phalanges can occur in long-standing and severe cases. 5,6

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Section: Ach Evolving Into Gpp and Ach With Gppmentioning

confidence: 99%

“…Table 2 summarises details of case reports of ACH with GPP. 6,7,[50][51][52] Females predominate and ACH can occur before or after GPP.…”

Section: Ach Alone and Predominate Achmentioning

confidence: 99%

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Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?

Chularojanamontri

Rattanakorn

Julanon

et al. 2023

Experimental Dermatology

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“…15 We have identified five case reports of patients with ACH treated with IL-12/23 inhibitors and four case reports of patients with ACH treated with IL-23 inhibitors in the literature, involving a total of twelve patients with ACH, as detailed in Table 1. 11,[16][17][18][19][20][21][22][23] Five patients were treated with Guselkumab, two with Risankizumab and five with Ustekinumab. Ustekinumab was reported to be effective, either as monotherapy or along with acitretin, 11,[20][21][22][23] but only one patient achieved a satisfactory clinical response at the recommended dose and frequency.…”

Section: Discussionmentioning

confidence: 99%

Acrodermatitis Continua of Hallopeau Successfully Treated with Ustekinumab: A Case Report and Literature Review

Shi¹,

Zeng²,

Huang³

et al. 2023

CCID

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Acrodermatitis continua of Hallopeau (ACH) is a rare variant of pustular psoriasis that presents as a sterile pustular eruption of the periungual and subungual regions. It affects the skin and nail bed and can lead to distal phalangeal destruction as the disease progresses. ACH is an incurable disease that requires long-term maintenance therapy to prevent any complications. Because ACH is a variant of pustular psoriasis, it is commonly treated with anti-psoriatic therapies. Unfortunately, it is resistant to many available anti-psoriatic therapies, and there are no clinical guidelines for it; the treatment is therefore highly challenging. Current treatment strategies are mostly based on a few case reports and case series. In this study, we present a case of ACH in a 24-year-old man with a long history of severe skin lesions and overt onychodystrophy, successfully treated with Ustekinumab. In this patient, we observed rapid improvement in skin lesions and symptoms. Ustekinumab can considerably improve other symptoms besides plaque psoriasis. The treatment and excellent outcomes of Ustekinumab may provide clinical benefits to more patients and serve as a reference for other dermatologists.

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“…Guselkumab is a human IL‐23 p19 subunit monoclonal antibody. A 52‐week, phase 3, multicenter, open‐label study reported the efficacy and safety in adults with GPP 73 . Risankizumab is another human IL‐23 p19 subunit monoclonal antibody.…”

Section: Systemic Treatmentsmentioning

confidence: 99%

The update of treatment strategies in pediatrics with generalized pustular psoriasis in China

Chen,

Xiang,

Wang

et al. 2023

Pediatric Investigation

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Generalized pustular psoriasis (GPP) is a severe subtype of psoriasis, commonly combined with systemic inflammation. Gene mutations have been found to be associated with GPP and vary by ethnicity. Systemic treatments are usually required for the severity and potential complications of GPP. However, there is no common consensus in China, especially among pediatric patients, whose data are scarce. Acitretin, methotrexate, and cyclosporine are widely used in pediatrics with GPP, while the adverse effects should be highlighted. The emergence of different biological agents brings us into a new era. This article discusses the genetic background of Chinese patients and demonstrates the evidence of treatment in pediatrics with GPP.

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A case of acrodermatitis continua of Hallopeau evolving into generalized pustular psoriasis successfully treated with guselkumab

Cited by 7 publications

References 5 publications

Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?

Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?

Acrodermatitis Continua of Hallopeau Successfully Treated with Ustekinumab: A Case Report and Literature Review

The update of treatment strategies in pediatrics with generalized pustular psoriasis in China

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