The update of treatment strategies in pediatrics with generalized pustular psoriasis in China

Abstract

Generalized pustular psoriasis (GPP) is a severe subtype of psoriasis, commonly combined with systemic inflammation. Gene mutations have been found to be associated with GPP and vary by ethnicity. Systemic treatments are usually required for the severity and potential complications of GPP. However, there is no common consensus in China, especially among pediatric patients, whose data are scarce. Acitretin, methotrexate, and cyclosporine are widely used in pediatrics with GPP, while the adverse effects should be highlighted. The emergence of different biological agents brings us into a new era. This article discusses the genetic background of Chinese patients and demonstrates the evidence of treatment in pediatrics with GPP.

Generalized pustular psoriasis in a toddler with IL36RN mutation: a case report

“…Childhood GPP manifests at any age, although it is notably more frequent within the first year of life. In contrast to adulthood GPP, the childhood GPP has a higher incidence in males (8)(9)(10). Despite its rarity, early intervention is crucial, as complications can be life-threatening, including superimposed bacterial infections and sepsis (1,11).…”