A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial

Bò, Cristian Del; Bernardi, Stefano; Cherubini, Antonio; Porrini, Marisa; Gargari, Giorgio; Hidalgo‐Liberona, Nicole; González‐Domínguez, Raúl; Zamora-Ros, Raúl; Peron, Gregorio; Marino, Mirko; Gigliotti, Letizia; Winterbone, Mark S.; Kirkup, Benjamin; Kroon, Paul A.; Andrés‐Lacueva, Cristina; Guglielmetti, Simone; Riso, Patrizia

doi:10.1016/j.clnu.2020.12.014

Cited by 62 publications

(54 citation statements)

References 95 publications

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“…Bifidobacteria have also been identified as health-promoting genera that increases butyrate production and thus contributes to improvements in the gut barrier and metabolic outcomes ( Seganfredo et al., 2017 ). Similarly, Faecalibacterium exhibits an enriched polyphenol-rich dietary pattern, which could improve gut barrier function ( Del Bo' et al., 2020 ), and the prophylactic use of Faecalibacterium could also prevent the acute breakdown of the colonic epithelial barrier ( Lapiere et al., 2020 ). Thus, in both the research and healthcare product markets, Bifidobacterium is a very common commercialized probiotics, and Faecalibacterium shows strong promise as effective and safe probiotics.…”

Section: Discussionmentioning

confidence: 99%

Synbiotics Supplements Lower the Risk of Hand, Foot, and Mouth Disease in Children, Potentially by Providing Resistance to Gut Microbiota Dysbiosis

Guo

Lan

Wen

et al. 2021

Front. Cell. Infect. Microbiol.

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BackgroundHand, foot and mouth disease (HFMD) is an acute enterovirus-induced disease. Gut microbiota dysbiosis has been identified as a factor that plays an important role in enteral virus infection, but the gut microbiota profile in hand, foot and mouth disease has rarely been studied in a large population.MethodsA total of 749 children (HFMD: n = 262, healthy control: n = 487) aged 2 to 7 years were recruited from hospitals and communities in the period from May to July, 2017. Clinical and demographical information was collected by trained personnel, and fecal samples were collected and processed for 16S ribosomal RNA(rRNA) gene sequencing.ResultsWe observed a significant alteration in the microbiota profile of children with HFMD compared with that of control children. Patients with enteroviruses A71(EV71) positive had more dysbiotic gut microbiota than those with coxsackievirus A16 (CAV16) positive. We found that Prevotella and Streptococcus were enriched in children with HFMD, whereas beneficial bacteria, including Bifidobacterium and Faecalibacterium, were depleted. Children with synbiotics supplements had lower risk of HFMD and we observed that the gut microbiota of HFMD patients who were administered synbiotics exhibited potential resistance to the dysbiosis detected in HFMD.ConclusionsThis study suggested that the gut microbiota of patients with hand, foot and mouth disease exhibits dysbiosis and that synbiotics supplements potentially helps maintain the homeostasis of the gut flora.

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Section: Discussionmentioning

confidence: 99%

Synbiotics Supplements Lower the Risk of Hand, Foot, and Mouth Disease in Children, Potentially by Providing Resistance to Gut Microbiota Dysbiosis

Guo

Lan

Wen

et al. 2021

Front. Cell. Infect. Microbiol.

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“…The treatment with Bacillus coagulans and the prebiotic inulin significantly inhibits serum amyloid A protein in arthritic rats and promotes a significant TNF release decrease (de Oliveira, 2019). Moreover, a polyphenol-rich diet was proved could reduce serum zonulin levels(an indirect marker of intestinal permeability) and blood pressure and increase fiber-fermenting and butyrate-producing bacteria (Del Bo' et al, 2020). Therefore, the flavones, a kind of polyphenol, in SND may be one reason for the increase of these probiotics.…”

Section: Discussionmentioning

confidence: 99%

Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice

Wang

Zhang

et al. 2021

Front. Pharmacol.

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Sini Decoction (SND), as a classic prescription of Traditional Chinese Medicine (TCM), has been proved to be clinically useful in cardiomyopathy and inflammatory bowel diseases. However, the role and mechanism of SND in colitis-associated cancer remains unclear. This study aims to evaluate the effect of SND on colorectal cancer(CRC) symptoms and further explore the changes of gut microbes mediated by SND extract in azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mice through 16 S rRNA sequencing. Our results indicated that treatment with SND extract could ameliorate the tumors' malignant degree by decreasing tumor number and size. Also, the expression levels of Cyclooxygenase 2 and Mucin-2, which are typical CRC biomarkers, were reduced compared to the CRC group. In the meantime, SND extract can upregulate CD8+ T lymphocytes' expression and Occludin in the colonic mucosal layer. Besides, SND inhibited the expression of CD4+ T cells and inflammatory cytokines in CRC tissue. According to bioinformatics analysis, SND extract was also suggested could modulate the gut microbial community. After the SND treatment, compared with the CRC mice model, the number of pathogenic bacteria showed a significant reduction, including Bacteroides fragilis and Sulphate-reducing bacteria; and SND increased the relative contents of the beneficial bacteria, including Lactobacillus, Bacillus coagulans, Akkermansia muciniphila, and Bifidobacterium. In summary, SND can effectively intervene in colorectal cancer development by regulating intestinal immunity, protecting the colonic mucosal barrier, and SND can change the intestinal microbiota composition in mice.

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“…Furthermore, the ablation of the entire GM via an antibiotic cocktail remarkably reduced the incidence of hypertension-related aneurysms suggesting that GM contributes to the pathophysiology of aneurysms by regulating inflammatory and immune response (Shikata et al, 2019). A randomized controlled trial found that dietary intervention rich in polyphenols can significantly improve the intestinal permeability of the elderly, increase the number of cellulolytic and butyrate producing bacteria in the intestinal flora, and reduce blood pressure (Del Bo et al, 2020).…”

Section: Hypertensionmentioning

confidence: 99%

Role and Mechanism of Gut Microbiota in Human Disease

Chen

Zhou

Wang

2021

Front. Cell. Infect. Microbiol.

219

102

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The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic diseases. The underlying mechanisms of GM on human diseases are incredibly complicated. This review focuses on the regulation and mechanism of GM on neurodegenerative diseases, cardiovascular diseases, metabolic diseases and gastrointestinal diseases, thus providing a potential target for the prevention and treatment of disease.

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A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial

Cited by 62 publications

References 95 publications

Synbiotics Supplements Lower the Risk of Hand, Foot, and Mouth Disease in Children, Potentially by Providing Resistance to Gut Microbiota Dysbiosis

Synbiotics Supplements Lower the Risk of Hand, Foot, and Mouth Disease in Children, Potentially by Providing Resistance to Gut Microbiota Dysbiosis

Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice

Role and Mechanism of Gut Microbiota in Human Disease

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