Synbiotics Supplements Lower the Risk of Hand, Foot, and Mouth Disease in Children, Potentially by Providing Resistance to Gut Microbiota Dysbiosis

Guo, Xiaoying; Lan, Zixin; Wen, Yaling; Zheng, Chengbin; Rong, Zuhua; Liu, Tao; Chen, Siyi; Yang, Xingfen; Zheng, Huimin; Wu, Wei

doi:10.3389/fcimb.2021.729756

Cited by 5 publications

(3 citation statements)

References 46 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There seemed difference in gut microbiota composition and richness between two groups. This result was consistent with the previous study [ 8 ]. Further studies with a large number of participants are needed.…”

Section: Discussionsupporting

confidence: 94%

“…A study showed that the composition of the gut microbiota of patients with HFMD differed from that of healthy controls [ 7 ]. In patients with HFMD, relative abundances (RAs) of Prevotella and Streptococcus were higher, whereas Bifidobacterium and Faecalibacterium were depleted [ 8 ]. Li et al recently reported that a reduction in bacterial diversity of gut microbiota was observed in children with HFMD.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Integrated analysis reveals important differences in the gut and oropharyngeal microbiota between children with mild and severe hand, foot, and mouth disease

Zhang

Mou

et al. 2023

Emerging Microbes & Infections

View full text Add to dashboard Cite

Little is known about alternation and difference in gut microbiota between patients with mild and severe hand, foot, and mouth disease (HFMD). We investigated the differences in gut and oropharynx microbiota between mild and severe HFMD in young children and changes in bacterial profiles as the disease progresses from acute to convalescent phase. Forty-two patients with confirmed HFMD were studied, among which 32 had severe HFMD and 10 had mild HFMD. First rectal swabs were collected from all patients at an average of 2 days (acute phase) after the onset of symptoms, and second rectal swabs were collected from 8 severe patients at day 9 (convalescent phase) after the onset. Oropharyngeal swabs were obtained from 10 patients in the acute phase and 6 in the convalescent phase. 16S rRNA sequencing was performed for all 70 samples. Compared with mild HFMD, severe HFMD exhibited significantly decreased diversity and richness of gut microbiota. Gut microbiota bacterial profiles observed in the acute and convalescent phases resembled each other but differed from those in mild cases. Additionally, 50% of patients with severe HFMD in the acute phase harboured a dominant pathobiontic bacterial genus. However, none of the patients with mild HFMD had such bacteria. Similar bacterial compositions in oropharynx microbiota were detected between mild and severe cases. Our findings indicate that severe HFMD exhibits significantly impaired diversity of gut microbiota and frequent gut and oropharyngeal inflammation-inducing bacteria. However, the results should be interpreted with caution as the number of subjects was limited.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Integrated analysis reveals important differences in the gut and oropharyngeal microbiota between children with mild and severe hand, foot, and mouth disease

Zhang

Mou

et al. 2023

Emerging Microbes & Infections

View full text Add to dashboard Cite

show abstract

“…In addition, we concluded that administered synbiotics supplements potentially provide better resistance to gut dysbiosis in patients with HFMD than probiotics or prebiotics alone. Greater gut flora disturbance was observed in patients who were enterovirus A71 (EV71)-positive than in those who were coxsackievirus A16 (CAV16)-positive 14 .…”

Section: Introductionmentioning

confidence: 99%

A large scale 16S ribosomal RNA gene amplicon dataset of hand, foot and mouth patients and healthy individuals

et al. 2023

Self Cite

View full text Add to dashboard Cite

There is evidence linking hand, foot and mouth disease (HFMD) to gut microbiota dysbiosis, and this relationship was corroborated in a large HFMD patient population in our previous study. Here, we present a bacterial 16S rRNA gene dataset from faecal samples of 713 individuals (254 HFMD patients, 459 healthy controls) aged 2 to 7 years residing in Heyuan and Jiangmen counties, Guangdong Province, southern China. Microbiome analysis indicated a significant increase in genus Prevotella, Cetobacterium, and Megamonas was observed in patients with HFMD, whereas a large increase in genus Bacteroides, Ruminococcus, and Faecalibacterium were seen in the control group. We also share the bioinformatic analytical pipeline for this analysis, from data preprocessing to data filtering and amplicon sequence variant (ASV) table generation. We expect that the dataset will be reprocessed, evaluated and fully analysed with various analysis methods to further elucidate the role of the gut microbiota in HFMD development.

show abstract

Impact of the Microbiota on Viral Infections

Campbell

Ingle

et al. 2023

Annu. Rev. Virol.

View full text Add to dashboard Cite

The mammalian gastrointestinal tract (GIT) hosts a diverse and highly active microbiota composed of bacteria, eukaryotes, archaea, and viruses. Studies of the GIT microbiota date back more than a century, although modern techniques, including mouse models, sequencing technology, and novel therapeutics in humans, have been foundational to our understanding of the roles of commensal microbes in health and disease. Here, we review the impacts of the GIT microbiota on viral infection, both within the GIT and systemically. GIT-associated microbes and their metabolites alter the course of viral infection through a variety of mechanisms, including direct interactions with virions, alteration of the GIT landscape, and extensive regulation of innate and adaptive immunity. Mechanistic understanding of the full breadth of interactions between the GIT microbiota and the host is still lacking in many ways but will be vital for the development of novel therapeutics for viral and nonviral diseases alike. Expected final online publication date for the Annual Review of Virology, Volume 10 is September 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

show abstract

Synbiotics Supplements Lower the Risk of Hand, Foot, and Mouth Disease in Children, Potentially by Providing Resistance to Gut Microbiota Dysbiosis

Cited by 5 publications

References 46 publications

Integrated analysis reveals important differences in the gut and oropharyngeal microbiota between children with mild and severe hand, foot, and mouth disease

Integrated analysis reveals important differences in the gut and oropharyngeal microbiota between children with mild and severe hand, foot, and mouth disease

A large scale 16S ribosomal RNA gene amplicon dataset of hand, foot and mouth patients and healthy individuals

Impact of the Microbiota on Viral Infections

Contact Info

Product

Resources

About