Relationship Between Xanthine Oxidase, Ischemia Modified Albumin, Nitric Oxide with Antioxidants in Non Pregnants, Pre and Post-delivery of Normal Pregnants and Preeclampsia

Bambrana, Vanishree; Dayanand, C. D.; Kotur, Pushpa

doi:10.1007/s12291-016-0599-0

Cited by 11 publications

(17 citation statements)

References 29 publications

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“…Increased IMA during the first trimester has been shown in pregnant with premature preeclampsia and then proposed as an early indicator of this complication [146]. This indicator returns to normal within 48 hours of birth, with symptoms of preeclampsia disappearing [147]. A meta-analysis of publications available in NCBI PubMed and other databases conducted by Reddy et al [153] showed that IMA is a potentially useful biomarker for PE with reasonable accuracy (AUC = 0:860).…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

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Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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“…Similarly, Bambrana et al, (4) reported reversal of the changes in oxidants-antioxidants homeostasis evinced within 48 h after delivery in PE.…”

Section: Discussion:-mentioning

confidence: 81%

“…Thereafter, Bambrana et al (4) reported that in PE women XOA, MDA and UA levels were significantly increased, while total antioxidant status (TAS) and levels of SOD and glutathione reductase (GR) were decreased in PE versus normotensive pregnant women. Recently, Barneo-Caragol et al (28) found serum UA levels were significantly different between non-pregnant and normotensive pregnant women in the 1 st , 2 nd and 3 rd trimesters and increases gradually as the pregnancy progresses.…”

Section: Discussion:-mentioning

confidence: 99%

“…Pre-eclampsia (PE) is a pregnancy-specific disorder (2) characterized by new onset of maternal hypertension and proteinuria after 20 weeks of gestation in a previously normotensive woman (3) . PE is a multisystem disorder involves altered homeostasis of oxidants-antioxidants, inflammatory process and endothelial dysfunction (4) During the physiological process of oxidation of organic materials by molecular oxygen to produce energy, a number of reactive oxygen species (ROS) are formed (5) . Normally, ROS are neutralized by a broad spectrum of naturally occurring protective antioxidants, such as superoxide dismutase (SOD), so as to prevent oxidative stress (OS) (6) that implies an imbalance between ROS production and cellular and tissue antioxidant defense system (7) .…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

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Maternal Oxidant-Antioxidant Homeostasis During Normotensive and Preeclamptic Pregnancy.

MD¹,

MD²,

MD³

2018

IJAR

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Objectives: To evaluate changes in oxidant milieu in normotensive pregnant women (No PE) and those who developed pre-eclampsia (PE) and to define a relation between these changes and PE development. Patients & Methods: All pregnant women gave three blood samples at 12 th week (S1) gestational age, start of 3 rd trimester (S2) and 48-hr postpartum (S3) for spectrophotometeric estimation of serum levels of malondialdehyde (MDA) and uric acid (UA), and activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and catalase activity. Control group included a similar number of non-pregnant women. Blood pressures were estimated at 1 st visit and monthly for diagnosis of PE. Results: 65 pregnant women developed PE; 54 had mild and 11 had severe PE; while 19 women developed early and 46 late PE. Sample S1 levels showed non-significant differences between all study participants. S2 serum MDA levels were significantly higher in pregnant women than their S1 and control levels and in PE versus No PE women. S2 serum UA levels were significantly higher in PE women than their S1, control and corresponding levels in No PE women. S2 serum SOD and GPx activity was significantly lower in PE women than their S1, control and corresponding measures in No PE women. Serum GR and catalase activities were significantly lower in S2 samples of pregnant women than their S1 and control activities with significantly lower activity in No PE women. S3 serum levels of MDA and UA were decreased and activities of antioxidant enzymes were adjusted in S3 sample than in S2 sample, but with significant difference between PE and No PE women. Statistical analysis defined serum MDA at ≥13.2±0.128 µmole/L and GPx activity at ≥450 U/L as risk cutoff point for PE development. Conclusion: Pregnancy is stressful condition associated with activation of oxidative stress (OS) and overproduction of oxidative products and disturbed activity of antioxidant enzymes. Exaggerated OS compromises placental functions and induces development of hypertensive manifestations. Elevated serum MDA and GPx enzyme

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“…In our earlier research reports, we presented increased concentration of oxidative stress and decreased total antioxidant status [12] and also increased xanthine oxidase activity with the inverse relation of nitric oxide in pre-eclampsia [13,14]. There is seldom information available with respect to phospholipase A 2 and plasma elastase in pre-eclampsia.…”

Section: Introductionmentioning

confidence: 98%

Phospholipase a 2 , Plasma Elastase Activity in Pre- And Post-Partum of Pre-Eclamptic Women

Dayanand

Bambrana

Sheela

2016

Asian J Pharm Clin Res

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Objective: The objectives of the present study were to evaluate the activity of phospholipase A 2 , plasma elastase enzymes and to assess relation with an inflammatory marker high sensitive C-reactive protein (hs-CRP) in nonpregnant before and after delivery of normotensive pregnant and preeclamptic women. Methods:The study population consists of three groups: Nonpregnant (Group 1, n=57), normotensive pregnant (Group 2, n=57), and pre-eclamptic women (Group 3, n=57). Groups 2 and 3 were followed after delivery within 48 hrs. Phospholipase A 2 , plasma elastase, and hs-CRP levels were determined spectrophotometrically. Results:The plasma elastase, phospholipase A 2 activity, and hs-CRP were elevated in pre-eclampsia significantly (p<0.05), nonsignificant rise in normotensive pregnant before delivery condition compared to nonpregnant women. However, plasma elastase in normal pregnancy and pre-eclampsia were decreased by 1.2-and 2.07-fold, respectively, after delivery. Whereas phospholipase A 2 and hs-CRP found to be nonsignificantly decreased in the postdelivery status of the both the groups. Receiver operating characteristics curve analysis showed that elastase enzyme has diagnostic importance to assess inflammation on the basis of area under curve (0.758). Conclusion:Our research findings generated knowledge about raised level of plasma elastase enzyme by neutrophil degranulation represents inflammation in pre-eclampsia. Elevated elastase, phospholipase A 2 with hs-CRP in pre-eclampsia serves as indicators of inflammation.

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Relationship Between Xanthine Oxidase, Ischemia Modified Albumin, Nitric Oxide with Antioxidants in Non Pregnants, Pre and Post-delivery of Normal Pregnants and Preeclampsia

Cited by 11 publications

References 29 publications

Ischemia-Modified Albumin: Origins and Clinical Implications

Ischemia-Modified Albumin: Origins and Clinical Implications

Maternal Oxidant-Antioxidant Homeostasis During Normotensive and Preeclamptic Pregnancy.

Phospholipase a 2 , Plasma Elastase Activity in Pre- And Post-Partum of Pre-Eclamptic Women

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