Toxocariasis and childhood asthma: A case-control study

Cadore, Priscila Silva; Zhang, Linjie; Lemos, Liliam de Lima; Lorenzi, Carolina; Telmo, Paula de Lima; Santos, Paula Costa; Mattos, Gabriela Torres; Vignol, Flávia Saraçol; Prietsch, Sílvio Omar Macedo; Berne, Maria Elisabeth Aires; Scaini, Carlos James

doi:10.3109/02770903.2015.1064951

Cited by 19 publications

(13 citation statements)

References 46 publications

(52 reference statements)

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“…A meta-analysis study including seven studies on children and three studies on adults involving a total of 1530 participants (723 cases of asthma and 807 controls) revealed a significant association between Toxocara seropositivity and asthma (OR: 3.36, 95% CI: 1.76 -6.42) (3). However, another study that was performed in Brazil with inclusion criteria similar to those used in our study did not find this association (18).…”

Section: Discussioncontrasting

confidence: 54%

Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran

Sadri

Gharavi

Arjmand³

et al. 2019

Arch Pediatr Infect Dis

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Background: It has been proposed that the migration of Toxocara canis larvae through the lungs is a contributing factor in the development of asthma and association of asthma and toxocariasis has been reported. The seroprevalence of toxocariasis varies widely among children living in different countries and even in different regions of a single country. Objectives: The aim of this study is to compare seroprevalence of anti-Toxocara antibodies in asthmatic and healthy children in Karaj, Iran. Methods: A serological study was conducted in children aged 1 to 15 years old for detection of antibodies to Toxocara canis in two groups (92 asthmatic children and 100 non-asthmatic children as control group), using commercial ELISA method for determination of IgG antibodies against Toxocara. Results: Only one patient (1.09%) had positive levels of anti-Toxocara antibodies in the case group, while no one had them in the control group. The results showed that there was no significant correlation between IgG antibodies against Toxocara canis and asthma. More than 90% of children in both case and control groups were residents of urban areas. Conclusions: We did not find any association between Toxocara infection and childhood asthma, suggesting that it may not be a common risk factor for childhood asthma in our urban area.

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Section: Discussioncontrasting

confidence: 54%

Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran

Sadri

Gharavi

Arjmand³

et al. 2019

Arch Pediatr Infect Dis

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“…Studies on Toxocara spp. seropositivity in the USA (Sharghi et al , 2001), Spain (Gonzalez-Quintela et al , 2006), Turkey (Kustimur et al , 2007), Sri Lanka (Fernando et al , 2009), Brazil (Cadore et al , 2016; Silva et al, 2017), and Norway (Jõgi et al , 2018) with clinical asthma showed no difference in Toxocara spp. infection between asthmatic and non-asthmatic individuals.…”

Section: Discussionmentioning

confidence: 99%

Toxocara sero-prevalence and its relationship with allergic asthma in asthmatic patients in north-eastern Iran

2018

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Toxocariasis is an important neglected tropical disease that has been suggested as a possible etiologic agent of asthma. The objective of the present study was to investigate possible significant association between Toxocara seroprevalence and asthma in a clinic-based case-control study. Blood samples were collected from human subjects aged 5–70 years, 50 of whom had signs of asthma and 50 of whom had no signs of asthma. Risk factors for asthma and Toxocara spp. infection were assessed by a questionnaire given to each patient. Blood samples were analysed to measure levels of anti-Toxocara spp. immunoglobulin G (IgG). Patients with bronchial asthma were observed to have higher Toxocara spp. seropositivity than that of the non-asthmatic controls (6 vs 2%, P = 0.47). The mean anti-Toxocara spp. antibody titre was not significantly higher in patients with bronchial asthma than in individuals without asthma (P = 0.395, 95% CI = 0.579–1.45). There was no significant difference in the mean age, sex, social class, exposure to smoking and presence of domestic dog or cat at home between the two groups (P ≥ 0.05). The presence of anti-Toxocara spp. IgG was statistically associated with higher blood eosinophils, but it was not associated with asthma (P ≥ 0.05). The observed relationship between exposure to Toxocara spp. infection and bronchial asthma in Iranian patients warrants further evaluation. An understanding of any potential influence on the pathogenesis of human asthma provides a potential avenue for prevention.

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“…The patient only showed marked improvement after treatment with thiabendazole. On the other hand, Grama et al 55 and Cadore et al 56 did not find an association between atopy and an increased risk of asthmatic manifestations in children with serological tests positive for anti- Toxocara antibodies. In 2012, Mendonça et al 51 did not find an association between positivity for aeroallergens and Toxocara infections in children living in poor areas of Salvador (Bahia State) and postulated that increased polyclonal IgE levels and the induction of a modified Th2 immune response to Toxocara infection might prevent the development of skin hypersensitivity to aeroallergens.…”

Section: Frequency and Characteristics Of Human Infections Due To Toxocaramentioning

confidence: 91%

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Chieffi¹,

Lescano²,

Fonseca³

et al. 2021

RRTM

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Toxocariasis and childhood asthma: A case-control study

Cited by 19 publications

References 46 publications

Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran

Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran

Toxocara sero-prevalence and its relationship with allergic asthma in asthmatic patients in north-eastern Iran

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

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