Introduction: Migration of Toxocara canis larvae was investigated in male and female Rattus norvegicus. Methods: Eighteen male and 18 female R. norvegicus were infected with 300 T. canis eggs. Three male and three female rats were euthanized at 3, 7, 10, 15, 30, and 60 days post-infection, and T. canis larvae were recovered by means of organ and tissue digestion. Results: Female rats showed a greater number of larvae in the liver than males. Conclusions: Paratenic host sex influences the migration pattern of T. canis larvae.
BALB/c mice were inoculated with 5-500 Toxocara canis infective eggs, and bled at 15-120 days post infection (dpi) to evaluate the dynamics of IgG antibody response and larvae distribution. Positive results were observed in all occasions for every inoculum, and a direct proportional relationship between antibody detection and the parasitic load was observed. In samples collected at 60 dpi, detection of IgG was more intense, especially with the 50 and 500 egg doses; also, a correlation between antibody level and egg count was observed with these two inocula. At 120 dpi, a decrease in antibody titer was observed for all groups; and at the end of the experiment, larvae were recovered from carcass, liver and brain. In the liver, larvae were only found in mice inoculated with 500 T. canis eggs. In carcasses, these were recovered in all groups, and the group inoculated with 50 eggs showed the highest percentage of larvae in the brain.
This is a review of the published contributions made by Brazilian researchers between 2010 and 2020 on the natural history of human toxocariasis and the effects of human toxocariasis on nonhuman paratenic hosts.
Ao meu orientador, Prof. Associado Ronaldo César Borges Gryschek, pela oportunidade, confiança, ensinamentos e constante suporte durante todo o processo; por acreditar no meu potencial e incentivar o meu aprendizado. Á Dra. Susana Angélica Zevallos Lescano por acreditar em mim desde o início; pela confiança, orientação, paciência, companheirismo, ensinamentos, amizade, apoio e porto seguro em todas as fases do Mestrado. Esse trabalho não seria possível sem você ao meu lado. Á Dra. Fabiana Martins de Paula pela orientação em todas as fases da reação em cadeia da polimerase e auxílio em diversas etapas da dissertação. À Dra. Fernanda Malta e ao LIM-07, pelo suporte durante a realização da reação em cadeia da polimerase, pela realização do sequenciamento e por ceder os materiais e aparelhagem necessários para a realização dessa técnica. Ao Dr. Sérgio Vieira dos Santos pela ajuda durante o ELISA, a reação em cadeia da polimerase, análise estatística e durante todo o trabalho, compartilhando seu conhecimento sem vaidade.
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