“…Several thiazole derivatives have been reported to show significant antimicrobial, antitumor, antiviral, antimalarial, anthelmintic, antidiabetic, antioxidant, anticonvulsant, antiasthmatic, analgesic, anti-inflammatory, and other activities [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. In particular, the clinical efficacy of tiazofurin, bleomycins (BLMs), and dasatinib has pointed out the medicinal significance of thiazole scaffold for the treatment of cancer [ 14 , 15 , 16 ]. Recent studies have indicated that thiazole derivatives show significant antitumor activity against different cancer cell lines through the inhibition of histone deacetylases (HDACs), pro-matrix metalloproteinase activation, signal transducer and activator of transcription 3 (STAT3), Bcl-2 family, and kinases including Akt isoforms, aurora kinases, and cyclin-dependent kinases (CDKs) [ 17 , 18 , 19 , 20 ].…”