The aim of this work is the protection of piroxicam from photodegradation by forming inclusion complex with 2-hydroxypropyl-β-cyclodextrin. Piroxicam:2-hydroxypropyl-βcyclodextrin molecular inclusion complex was prepared by coprecipitation method with 1:1 molar ratio. Structural characterization of the complex, the corresponding physical mixture and complexing agents of piroxicam and 2-hydroxypropyl-β-cyclodextrin was carried out by X-ray diffraction (XRD), proton nuclear magnetic resonance (1 H-NMR) and Fourier transform infrared spectroscopy (FTIR). Photosensitivity to daylight of piroxicam and piroxicam:2-hydroxypropyl-β-cyclodextrin inclusion complex was investigated by FTIR. The investigations show that higher photostability of piroxicam was achieved in the complex than in non-complexed piroxicam.

The stability constants indicated the rapid release of EA from the inclusion complexes in the aqueous medium at 25 °C. The antioxidant activity of EA was increased, while the antimicrobial activity was preserved after complexation with CDs.

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Based on the obtained results, it can be concluded that the antimicrobial activity of BCA was remained unchanged after complexation.