Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide

Abstract

KEYWORDSNickel and copper metal complexes of N-(R-carbamothioyl)-4-nitrobenzamide (R = diphenyl and ethylbutyl) were synthesized and characterized by IR, 1 H NMR, mass spectrometry and elemental analysis. The spectroscopic data are consistent with the ligand and the metal complexes containing two O and S chelated ligands. N-(diphenylcarbamothioyl)-4nitrobenzamide, HL 1 , was characterized by a single crystal X-ray diffraction study. It crystallizes in the triclinic space group P1 with unit cell dimensions of a = 6.8044(4) Å, b = 10.0113(6) Å, c = 13.2365(8) Å, α = 6.8044(4) °, β = 78.171(4) °, γ = 13.2365(8)°, V = 882.43(9) Å 3 . The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The ligands and complexes were screened for their in vitro antibacterial activities and comparatively the complexes showed greater antibacterial efficacy than the thiourea derivative ligands.Thiourea derivatives Transition metal complexes X-ray structure determination Phase-transfer catalyst Antibacterial activity

Metal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex

“…Many biologically active thiourea-based (carboxamide) compounds have been reported possessing antibacterial [1][2][3] , antifungal 4,5 , anticancer 6,7 , antiviral 8 , pesticidal 9 , cytotoxic 10 , herbicidal 11 and insecticidal 12 activities. Thiourea derivatives have been effectively used in organocatalysis 13 and as curing agents for epoxy resins.…”

Crystal and molecular structure of bis(4-bromo-N-(diethylcarbamothioyl)benzamido)nickel(II) complex

“…Many benzoylthiourea compounds have been tested for their in vitro activity against a large variety of tumor lines and have been found to be as effective or better than traditional heavy metal anticancer drugs such as cis-platin [1]. Some acylthiourea derivatives exhibit antiviral [2], antibacterial [3], antifungal [4], antihelmintic [5,6], herbicidal [7], activities. 1,3-Dialkyl or diaryl thioureas exhibit significant antifungal activity against plant pathogens Pyricularia oryzae and Drechslera oryzae [8].…”

The complexing ability of n-substituted thiourea derivatives as chelating ligands in the reaction with PdCl2

“…The 1 H NMR spectra were recorded on a Varian VXR-300 (300 MHz, for HL 1 , HL 2 , complexes 1-4) and a Bruker Advance DRX-500 spectrometer (500.13 MHz for HL 3 , HL 4 , complexes 5, 6) in DMSO-d 6 solution using TMS as an internal standard. The PdCl 2 (Pd content 59%, Merck) was used as the starting metal salt.…”

“…Thiourea and its N-substituted derivatives are efficient complexing agents for metal ions, which are widely used as ligands in coordination chemistry [1][2][3]. The presence of unshared electron pairs in the sulphur atom and two nitrogen atoms allows to form the complex compounds with transition metal salts of the different type, many of which possess valuable applied properties (optical, semiconductor, biological, etc.)…”

“…Moreover, the use of biologically active ligands, an additive or synergistic effect manifests itself between the constituents of complexes [16,17]. Therefore, development of methods for the synthesis of different types of complexes based on thiourea derivatives is a promising trend in creating novel therapeutic and diagnostic agents [3,[18][19][20][21].…”