KEYWORDSThis article presents our research concerning the synthesis of new thiophene-thiourea derivatives (1-12) and their pharmacological properties. These novel thiophene-thiourea derivatives were synthesized and characterized by IR, 1 H and 13 C NMR spectroscopy, mass spectrometry and elemental analysis. The crystal structure of N,N-diphenyl-N'-(thiophene-2carbonyl)-thiourea was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21 with unit cell dimensions of a=11.7469(5) Å, b=6.0849(2) Å, c=12.5792(6) Å, β= 117.736(7) ° and V = 795.8(6) Å 3 . The mass fragmentation pattern has also been discussed. The synthesized compounds were screened for their in vitro antifungal activities against the standard strains: C. Albicans, C. Glabrata, and C. Tropicalis. The compounds N-

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KEYWORDSNickel and copper metal complexes of N-(R-carbamothioyl)-4-nitrobenzamide (R = diphenyl and ethylbutyl) were synthesized and characterized by IR, 1 H NMR, mass spectrometry and elemental analysis. The spectroscopic data are consistent with the ligand and the metal complexes containing two O and S chelated ligands. N-(diphenylcarbamothioyl)-4nitrobenzamide, HL 1 , was characterized by a single crystal X-ray diffraction study. It crystallizes in the triclinic space group P1 with unit cell dimensions of a = 6.8044(4) Å, b = 10.0113(6) Å, c = 13.2365(8) Å, α = 6.8044(4) °, β = 78.171(4) °, γ = 13.2365(8)°, V = 882.43(9) Å 3 . The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The ligands and complexes were screened for their in vitro antibacterial activities and comparatively the complexes showed greater antibacterial efficacy than the thiourea derivative ligands.Thiourea derivatives Transition metal complexes X-ray structure determination Phase-transfer catalyst Antibacterial activity

Abstract:

The title compound, C14H10BrN3O3S, crystallizes as two concomitant polymorphs that differ in colour (one yellow and one colourless). Only the structure of the colourless form could be determined. The mol­ecule exists in the thio­amide form with an intra­molecular N—H⋯O=C hydrogen bond across the thio­urea system. Mol­ecules are linked into layers parallel to (120) by Br⋯Onitro contacts [3.103 (1) Å], classical hydrogen bonds from the other NH function to the S atom and Nnitro⋯O=C contacts. The layers are linked by weak C—H⋯Onitro hydrogen bonds to produce the observed three-dimensional network.

The title compound, C14H18N2O3S, crystallizes in the thio­amide form with an intra­molecular N—H⋯O hydrogen bond associated with the thio­urea unit. With the benzoic acid and the butyrylthio­ureido units, the mol­ecule consists of two planar building blocks connected by the common NH function adjacent to the aromatic ring. The inter­planar angle is 33.38 (3)°. Mol­ecules are connected in chains parallel to [110] by classical hydrogen bonds of the N—H⋯O type from the other NH group to the benzoate C=O of a neighboring mol­ecule.

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The title compound, C17H16N2O3S, crystallizes in the thio­amide form with an intra­molecular N—H⋯O hydrogen bond across the thio­urea system. Mol­ecules are connected in chains parallel to [10] by hydrogen bonds from the second thio­urea N—H group to the benzoate C=O function.