Metal based drugs: design, synthesis and <i>in-vitro</i> antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex

Sumrra, Sajjad Hussain; Hanif, Muhammad; Chohan, Zahid H.; Akram, Muhammad Safwan; Akhtar, Javeed; Alshehri, Saad M.

doi:10.3109/14756366.2015.1050011

Cited by 35 publications

(14 citation statements)

References 36 publications

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“…The magnetic moment values (2.21 B.M., 2.13 B.M.) of these complexes also support 4-coordinate tetrahedral geometry and presence of one unpaired electron in d 9 [28]. Zn (II) complexes have d 10 configuration and were found to be diamagnetic.…”

Section: Uv/vis Data and Magnetic Momentmentioning

confidence: 60%

“…Zn (II) complexes have d 10 configuration and were found to be diamagnetic. The diamagnetic nature of this complex supports only presence of charge transfer band and absence of d-d transition proposing its tetrahedral geometry [28,29].…”

Section: Uv/vis Data and Magnetic Momentmentioning

confidence: 71%

“…Both the ligands and their metal complexes showed broad emission bands indicating charge transfer nature of the transitions. Significant differences in positions of emission maximum from those of the ligand and metal complexes establish the complexation process [28]. At excitation wavelength 320 nm, L 1 and L 2 showed the emission at 426 and 359 nm, and their complexes showed the emission at 370, 416, 430, 425, 427, 359, 386 and 368 nm for L 1 2 -Cu(II) and L 2 -Zn(II), respectively.…”

Section: Photo-physical Studiesmentioning

confidence: 92%

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Synthesis, structural and photo-physical studies of transition metal complexes with Mannich bases derived from 2-mercaptobenzimidazole

Imran¹,

Iqbal²,

Bokhari³

et al. 2018

Bull. Chem. Soc. Eth.

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Two Mannich base ligands, [1-(di-n-butylamine-N-methyl)mercapto-1H-benzimidazole] (L 1) and [1-(diphenylamine-N-methyl)mercapto-1H-benzimidazole] (L 2) have been synthesized and further reacted with Co(II), Ni(II), Cu(II) and Zn(II) ions to afford their respective complexes. The progress of the reaction was monitored by thin layer chromatography. The structural elucidation of Mannich base ligands and their metal complexes was done by Fourier Transform Infrared (FTIR), UV-Visible, Nuclear Magnetic Resonance spectroscopy (1 H NMR & 13 C NMR) and Atomic absorption spectroscopy (AAS) / Inductively coupled plasma emission spectroscopy (ICPES). FTIR and NMR studies supported the monoanionic bidentate coordination mode of L 1 and L 2 while tetrahedral geometries of metal complexes were proposed on the basis of AAS/ICP, magnetic moment and electronic spectroscopic data. The synthesized compounds were also investigated for their luminescent behavior which exhibited broad emission bands indicating charge transfer nature of the involved transitions.

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Section: Uv/vis Data and Magnetic Momentmentioning

confidence: 60%

Section: Uv/vis Data and Magnetic Momentmentioning

confidence: 71%

Section: Photo-physical Studiesmentioning

confidence: 92%

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Synthesis, structural and photo-physical studies of transition metal complexes with Mannich bases derived from 2-mercaptobenzimidazole

Imran¹,

Iqbal²,

Bokhari³

et al. 2018

Bull. Chem. Soc. Eth.

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“…The Zn(II) complex (4) of (L 1 ) was found to be the most active complex. The metal(II) complexes showed enhanced 34 activity results compared to their non-coordinated Schiff bases upon complexation ( Figure 2 ).…”

Section: Biological Studiesmentioning

confidence: 99%

Antimicrobial metal-based thiophene derived compounds

Yasmeen

Sumrra

Akram

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.

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“…This may be due to their higher yields with lower possibilities of isomer generation . Several bioactive compounds, such as sulfonamides, triazoles, isatins, and benzothiazines, have been modified structurally to cope with ever‐increasing pathogenic resistance as a result of their drug resistance . Specific biological roles of transition metals are also noteworthy regarding this development .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and biological screening of metal complexes of novel sulfonamide derivatives: Experimental and theoretical analysis of sulfonamide crystal

Sumrra

Hassan

Imran

et al. 2020

Applied Organom Chemis

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This study reports the synthesis of sulfonamide‐derived Schiff bases as ligands L1 and L2 as well as their transition metal complexes [VO(IV), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II)]. The Schiff bases (4‐{E‐[(2‐hydroxy‐3‐methoxyphenyl)methylidene]amino}benzene‐1‐sulfonamide (L1) and 4‐{[(2‐hydroxy‐3‐methoxyphenyl)methylidene]amino}‐N‐(5‐methyl‐1,2‐oxazol‐3‐yl)benzene‐1‐sulfonamide (L2) were synthesized by the condensation reaction of 4‐aminobenzene‐1‐sulfonamide and 4‐amino‐N‐(3‐methyl‐2,3‐dihydro‐1,2‐oxazol‐5‐yl)benzene‐1‐sulfonamide with 2‐hydroxy‐3‐methoxybenzaldehyde in an equimolar ratio. Sulfonamide core ligands behaved as bidentate ligands and coordinated with transition metals via nitrogen of azomethine and the oxygen of the hydroxyl group. Ligand L1 was recovered in its crystalline form and was analyzed by single‐crystal X‐ray diffraction technique which held monoclinic crystal system with space group (P21/c). The structures of the ligands L1and L2 and their transition metal complexes were established by their physical (melting point, color, yields, solubility, magnetic susceptibility, and conductance measurements), spectral (UV–visible [UV–Vis], Fourier transform infrared spectroscopy, 1H NMR, 13C NMR, and mass analysis), and analytical (CHN analysis) techniques. Furthermore, computational analysis (vibrational bands, frontier molecular orbitals (FMOs), and natural bonding orbitals [NBOs]) were performed for ligands through density functional theory utilizing B3LYP/6‐311+G(d,p) level and UV–Vis analysis was carried out by time‐dependent density functional theory. Theoretical spectroscopic data were in line with the experimental spectroscopic data. NBO analysis confirmed the extraordinary stability of the ligands in their conjugative interactions. Global reactivity parameters computed from the FMO energies indicated the ligands were bioactive by nature. These procedures ensured the charge transfer phenomenon for the ligands and reasonable relevance was established with experimental results. The synthesized compounds were screened for antimicrobial activities against bacterial (Streptococcus aureus, Bacillus subtilis, Eshcheria coli, and Klebsiella pneomoniae) species and fungal (Aspergillus niger and Aspergillus flavous) strains. A further assay was designed for screening of their antioxidant activities (2,2‐diphenyl‐1‐picrylhydrazine radical scavenging activity, total phenolic contents, and total iron reducing power) and enzyme inhibition properties (amylase, protease, acetylcholinesterase, and butyrylcholinesterase). The substantial results of these activities proved the ligands and their transition metal complexes to be bioactive in their nature.

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Metal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex

Cited by 35 publications

References 36 publications

Synthesis, structural and photo-physical studies of transition metal complexes with Mannich bases derived from 2-mercaptobenzimidazole

Synthesis, structural and photo-physical studies of transition metal complexes with Mannich bases derived from 2-mercaptobenzimidazole

Antimicrobial metal-based thiophene derived compounds

Synthesis, characterization, and biological screening of metal complexes of novel sulfonamide derivatives: Experimental and theoretical analysis of sulfonamide crystal

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