Clinical epidemiological profile of vitiligo in children and adolescents

Marinho, Flauberto de Sousa; Cirino, Pablo Vitoriano; Fernandes, Nurimar Conceição

doi:10.1590/abd1806-4841.20132219

Cited by 20 publications

(34 citation statements)

References 7 publications

(8 reference statements)

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“…15 Onset before age 2 years represents 11% of pediatric-onset cases, 28% of cases start between 2 and 5 years, 40% of cases begin between 5 and 10 years, and 21% between 10 and 18 years, demonstrating that median age of onset is between 5 and 10 years of age. 16 In a cohort of Indian children, 56.7% of pediatric cases were noted in childhood between 8 and 12 years. 17 Early-onset disease (before age 12 years) represented 35.2% of cases in an Indian cohort.…”

Section: Epidemiology Of Pediatric Vitiligomentioning

confidence: 99%

“…Of the 25% of children with vitiligo evaluated for psychological issues, 60% reported psychological problems in a cohort of 119 Brazilian children. 16 A recent review article of quality-of-life issues in childhood skin disease stated: "In general, patients with vitiligo experience low self-esteem, social stigmatization, shame, avoidance of intimacy, anxiety, depression, adjustment disorder, fear, suicidal ideation, and other psychiatric morbidity." 47 Recent studies have suggested that childhood vitiligo impacts quality of life similarly to psoriasis, as children enter adulthood.…”

Section: The Psychological Impact Of Vitiligomentioning

confidence: 99%

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A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

Ezzedine

Silverberg

2016

Pediatrics

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Vitiligo is a common inflammatory skin disease with a worldwide prevalence of 0.5% to 2.0% of the population. In the pediatric population, the exact prevalence of vitiligo is unknown, although many studies state that most cases of vitiligo are acquired early in life. The disease is disfiguring, with a major psychological impact on children and their parents. Half of vitiligo cases have a childhood onset, needing thus a treatment approach that will minimize treatment side effects while avoiding psychological impacts. Management of vitiligo should take into account several factors, including extension, psychological impact, and possible associations with other autoimmune diseases. This review discusses the epidemiology of vitiligo and outlines the various clinical presentations associated with the disorder and their differential diagnosis. In addition, the pathophysiology and genetic determinants, the psychological impact of vitiligo, and management strategies are reviewed.

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Section: Epidemiology Of Pediatric Vitiligomentioning

confidence: 99%

Section: The Psychological Impact Of Vitiligomentioning

confidence: 99%

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

Ezzedine

Silverberg

2016

Pediatrics

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“…It is the result of a loss of functioning of the melanocytes (4) due to destruction of or damage to these cells, resulting in decreased or absent pigmentation of the skin, hair, and mucous membranes (5)(6)(7). The pathogenetic mechanism of vitiligo is unknown (8).…”

mentioning

confidence: 99%

Pharmacologic Treatment of Vitiligo in Children and Adolescents: A Systematic Review

Menezes

Carvalho

Barreto

et al. 2016

Pediatric Dermatology

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The main outcome measurements were morphometric analysis performed using a computer program, hematologic or biochemical change, and photography (predominant). It is unclear which was the most effective treatment for vitiligo, however, it was found that these therapies are all promising in the treatment of the disease. With proper care, disease control and repigmentation, even if partial, can be achieved.

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“…Despite being the are similar for 0-5 and 6-10 years old, but those for the 12-18 year olds are different. While some authors report that the majority of their cases is aged between 6-12, 53.38% of the cases in our study was aged between 12-18 (18). The reason could be delayed arrival of the patients to us.…”

Section: Discussionmentioning

confidence: 60%

“…The most frequent non-segmental type vitiligo observed in children is generalized (78%), followed by focal vitiligo (1). Focal vitiligo is seen in around 14-29 % of the cases (18). Some authors have reported that in children vitiligo is mostly located around the eye and neck, followed by lower extremity, torso, upper extremity and perianal are (15).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

Akbaş¹,

Kılınç²,

Aktaş³

2019

Turkish Journal of Pediatric Disease

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Objective: Vitiligo is a disease for which the cause is not clearly known public but is common and is characterised by depigmented macules. It's incidence rate ranges between 0.1-11%. Incidence among children is not known clearly but it has been reported that in half of the cases lesions start before the age of, and in 25% they start before 10-14 years and it has different characteristics than that in adults. The aim of this study is to define the clinical and demographic characteristics of childhood vitiligo, identify the accompanying diseases and the treatment options that are provided. Material and Methods: The files of 105 paediatric patients diagnosed with vitiligo in our hospital's dermatology department during the 2011-2018 period have been retrospectively examined. Age, gender, starting age, disease duration, lesion area, vitiligo type, family vitiligo history, blood tests and accompanying diseases have been recorded. Vitiligo types have been divided into 2 main groups, namely segmental and no segmental. Cases with generalized (vulgar), focal, acral, acrofacial vitiligo have been included in non-segmental vitiligo cases. Results: 44.76% of the patients are female. The average age was 10.98±4.77 years, the average age when the condition started was 9.63±4.53 years and average duration of the disease was 19.19±19,60 months (1.59 years). Number of cases in 0-2 age group was 7 (6.66%), 3-5 age group was 10 (9.52%), 6-11 age group was 32 (30.47%), 12-18 age group was 56 (53.33%). In terms of duration of the disease, 0-2 months included 12 patients (11.42%), 3-6 months included 11 patients (10.47%), 7 months to 1 year included 9 patients (8.57%), and over a year included 73 patients (6.52%). With regards to the types of vitiligo, 6.66% (n=7) had segmental vitiligo, 92.38% (n=97) had non-segmental vitiligo, 0.95% (n=1) had mixed type vitiligo. 53.60% (n=52) of non-segmental vitiligo was focal vitiligo, 31.95% (n=31) was vitiligo vulgaris 7.21% (n=7) was acrofacial and 7.21% (n=7) was acral type. In terms of focal vitiligo 40.38% (n=21) had cheek involvement, 23.07% (n=12) periorbital involvement, 11.53% (n=6) perioral involvement, 7.69% (n=4) genital involvement and five cases (9.61%) had multiple involvements. In 30.4% of the cases (n=32), one or more coexisting disease has been observed to exist. Treatment options differed by age. While topical steroids and calcineurin inhibitors have been preferred in younger ages and in limited lesions, while in older ages and in more spread lesions phototherapy and systemic treatment methods have been practised. Conclusion: This study is addressing the clinical and demographic characteristics of children with vitiligo as well as the practised treatment options. In contrast to other studies, this study has concluded more incidences among males. Regarding people in the early stages of vitiligo and in lesions localised in head-neck area, micro-therapy has been observed to be effective and calcineurin inhibitors have hastened repigmentation.

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Clinical epidemiological profile of vitiligo in children and adolescents

Cited by 20 publications

References 7 publications

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

Pharmacologic Treatment of Vitiligo in Children and Adolescents: A Systematic Review

Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

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