RESUMOObjetivo: analisar os aspectos gerais do acesso dos homens adultos aos serviços de atenção primária à saúde. Método: trata-se de estudo quantitativo, exploratório e transversal, com 485 homens adultos, por meio de questionário, dados armazenados no software SPSS 20.0, submetidos à estatística descritiva e apresentados em tabelas com distribuição de frequências absoluta e relativa. Resultados: 32,6% visitam os serviços de atenção primária à saúde com regularidade. A demora para ser atendido (35,7%) e a ausência de doenças (33,8%) são os principais fatores impeditivos da acessibilidade masculina aos serviços de saúde; 39,4% desconhecem os dias de funcionamento da unidade; 75% consideram ser difícil agendar consultas e 21% desconhecem a política nacional dos homens. Conclusão: a maioria dos homens adultos não buscou com regularidade os serviços de Atenção Primária à Saúde. Ressaltou-se a importância do conhecimento das razões masculinas para não buscarem os serviços da atenção primária à saúde. Este estudo pode contribuir aos gestores a compreenderem essa realidade singular masculina no planejamento de ações visando à garantia da assistência à saúde mais resolutiva. Descritores: Saúde do Homem; Acesso aos Serviços de Saúde; Atenção Primária à Saúde; Saúde Pública; Assistência à Saúde; Enfermagem.ABSTRACT Objective: to analyze the general aspects of adult men's access to primary health care services. Method: this is a quantitative, exploratory and cross-sectional study with 485 adult men, using a questionnaire, data stored in SPSS 20.0 software, submitted to descriptive statistics and presented in tables with absolute and relative frequency distribution. Results: 32.6% visit regular primary health care services. The delay to be treated (35.7%) and the absence of diseases (33.8%) are the main impediments to male accessibility to health services; 39.4% are unaware of the unit's operating days; 75% consider it difficult to schedule consultations and 21% are unaware of the national men's policy. Conclusion: the majority of adult men did not seek regular Primary Health Care services. The importance of knowing the reasons for not seeking primary health care was emphasized. This study can contribute to the managers to understand this singular masculine reality in the planning of actions aiming to guarantee the health care more resolute. Descritores:  Human Health; Access to Health Services; Primary Health Care; Public Health; Health Care; Nursing.                                                                                                    RESUMEN Objetivo: analizar los aspectos generales del acceso de los hombres adultos a los servicios de atención primaria a la salud. Método: se trata de un estudio cuantitativo, exploratorio y transversal, con 485 hombres adultos, mediante cuestionario, datos almacenados en el software SPSS 20.0, sometidos a la estadística descriptiva y presentados en tablas con distribución de frecuencias absoluta y relativa. Resultados: el 32,6% visitan los servicios de atención primaria a la salud con regularidad. La demora para ser atendida (35,7%) y la ausencia de enfermedades (33,8%) son los principales factores impeditivos de la accesibilidad masculina a los servicios de salud; 39,4% desconocen los días de funcionamiento de la unidad; El 75% considera que es difícil programar consultas y el 21% desconocen la política nacional de los hombres. Conclusión: la mayoría de los hombres adultos no buscó con regularidad los servicios de Atención Primaria a la Salud. Se resaltó la importancia del conocimiento de las razones masculinas para no buscar los servicios de atención primaria a la salud. Este estudio puede contribuir a los gestores a comprender esta realidad singular masculina en la planificación de acciones para la garantía de la asistencia sanitaria más resolutiva. Descritores: Salud del Hombre; Acceso a los Servicios de Salud; Atención Primaria a la Salud; Salud Pública; Asistencia Sanitária; Enfermería.

Vitiligo is a disorder of the skin that causes depigmentation and asymptomatic macules whose exact cause is still unclear. Although its aetiology is not fully elucidated, the main theory of its pathomechanism is that it is associated with the autoimmune process. There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo, so our aim was to present a systematic review of the role of interleukins in vitiligo, focusing on interleukins. In this review, we included all studies assessing interleukin levels in vitiligo patients conducted up to June 2017. Quality assessment of these studies was performed using the Newcastle-Ottawa Scale (NOS). The interleukins mainly involved were IL-2, IL-4, IL-6, IL-10 and IL-17. The studies highlight the crucial role of IL-17 in the onset and progression of the disease, and its synergistic action with IL-2, IL-6 and IL-33. Dysregulated levels of the interleukins were also correlated with the stage of disease, the affected skin surface area, and indicated as the main factor for lymphocyte infiltration found in depigmented regions. These findings illustrate the growing need for new therapies targeting vitiligo and further research into the role of interleukins as an area of particular interest.

objective To analyse spatial patterns and the temporal tendency of mortality related to Chagas disease, in order to identify priority control areas in the state of Sergipe, Northeast Brazil. methods We conducted an ecological and time-series study with spatial analysis techniques on deaths from Chagas disease in the state of Sergipe (1996-2016). We used data from the Mortality Information System (SIM). The temporal analysis was performed using a statistical technique capable of describing changes in the trend pattern for the period. Thematic maps were elaborated from point and polygonal analyses. results There were 247 deaths related to Chagas disease, with a mean of 11.7 deaths/year, most of them male (64%), and aged 50-59 years (21%) and 60-69 years (26%). Two segments with increasing, non-constant and significant trends were identified: 1996-2005 (APC = 21.6%; P = 0.01) and 2005-2016 (APC = 4.4%; P = 0.01), with APPC = 11.8% (P = 0.01). A positive and significant spatial autocorrelation with areas of higher risk of death was found in the southern region of the state. conclusions The trend of mortality related to Chagas disease in the state of Sergipe was increasing during the period analysed, with a heterogeneous distribution of cases. A main risk area was identified in the southern region of the state.

Objetivo: Identificar pesquisas existentes na literatura que abordem os benefícios do método canguru. Método: Trata-se de uma revisão integrativa da literatura. As buscas nas bases de dados MEDLINE, LILACS, BDENF e SCIELO foram realizadas utilizando os descritores: “método canguru”, “benefício” e “recém-nascido de baixo peso” obedecendo as seis etapas do método considerando os critérios de inclusão. Resultados: Inicialmente foram encontrados 385 artigos nas bases de dados após seleção restaram 19. Do total de artigos analisados 58% abordaram os benefícios no método canguru para o recém-nascido, 16% discutiram os benefícios para a relação mãe e recém-nascido e 16% analisaram os benefícios do método para a instituição. Conclusão: Pode-se perceber que o Método Canguru traz benefícios para instituição, mãe e recém-nascido. Destaca-se a necessidade de novos estudos que avaliem outros benefícios do método canguru como padrão de cuidados a fim de expandir essa tecnologia em saúde que vai além das necessidades fisiológicas.

Background Restless legs syndrome (RLS) is more prevalent in chronic kidney patients than in the general population, but it is often diagnosed late and its predictors are unknown. Purpose To diagnose RLS in a group of chronic kidney patients on dialysis, determine its frequency and severity, compare the prevalence and severity of the condition among dialytic modalities, and identify possible predictive factors in this population. Methods An observational and cross-sectional study with 326 patients who had been on dialysis for more than 3 months, 241 on hemodialysis (HD) and 85 on automatic peritoneal dialysis (APD), using the criteria established by the International Study Group on RLS for the diagnosis and the RLS Rating Scale to determine its severity. Results RLS was diagnosed in 19.3% of the patients, 52.4% with severe or very severe forms. Patients with and without RLS did not differ in clinical and demographic characteristics and dialytic modality; however, patients on APD presented higher RLS severity compared to the HD group. Conclusions RLS is frequent in dialysis patients and occurs predominantly in its most severe forms; the dialytic modality seems to have no influence on its occurrence; however, it is more severe in patients on APD.

Objective: To compare the nursing workload measured by the Nursing Activities Score (NAS), between intensive care unit general adult ICU, and specialized surgical, cardiologic and trauma type.Methods: A literature review of the integrative type was carried out, searching the databases BDENF, LILACS, MEDLINE, and SCIELO, using the descriptors nursing, Intensive Care Unit, workload and Nursing Activities Score. They met the inclusion criteria 20 articles published in the period 2007 to 2017.Results: They show a high workload in the ICU, both in general ICUs and in all of the cited specificities, the same with a NAS score> 50.00, especially the trauma ICU, which was characterized with higher scores 72.00 and 71.3.Conclusion: In much of the research, the average number of nursing professionals calculated by the NAS is higher than the average number of professionals required by the legislation. It was observed that even in ICUs with the same specificity it was possible to perceive large differences in the mean of the NAS score, in this way, we understand that despite having the same specificity, the profile of the patient as well as that of the institution has its peculiarities requiring time to different assistance and consequently divergences in sizing. Objetivo: Comparar la carga de trabajo de enfermería medida por la Nursing Activities Score (NAS), entre la unidad de cuidados intensivos general de adultosy especializadas de quirúrgico, cardiología y trauma.Métodos: Realización de una revisión de la literatura del tipo integrativa. Búsqueda en las bases de datos BDENF, LILACS, MEDLINE, SCIELO, utilizando los descriptores enfermería, Unidad de Cuidados Intensivos, Carga de trabajo y Nursing Activities Score. Atendieron a los criterios de inclusión 20 artículos publicados en el periodo de 2007 a 2017.Resultados: Evidencian elevada carga de trabajo en UCI, tanto en UCIs general como en todas las especificidades citadas, las mismas con puntuación NAS > 50,00, destacando la UCI de trauma lo que se caracterizó con mayores marcadores 72,00 y 71,3.Conclusión: En gran parte de las investigaciones, la media de profesionales de enfermería calculada por la NAS es superior a la media de profesionales requerida por la legislación. Se observó que incluso en UCIs con la misma especificidad se perciben grandes diferencias en la media de la puntuación NAS, de esta forma, entendemos que a pesar de tener la misma especificidad, el perfil del paciente así como el de la institución tienen sus particularidades demandando tiempo de asistencia diferente y consecuentemente divergencias en el dimensionamiento. Objetivo: Comparar a carga de trabalho de enfermagem medida pelo Nursing Activities Score (NAS), entre unidade de terapia intensiva UTI geral adulto, e especializadas do tipo cirúrgica, cardiológica e trauma.Métodos: Foi realizada uma revisão de literatura do tipo integrativa, com busca nas bases de dados BDENF, LILACS, MEDLINE, e SCIELO, utilizando-se os descritores enfermagem, Unidade de Terapia Intensiva, carga de trabalho e Nursing Activities Score. Atenderam aos critérios de inclusão 20 artigos publicados no período de 2007 a 2017.Resultados: Evidenciam elevada carga de trabalho em UTI, tanto em UTIs geral quanto em todas as especificidades citadas, as mesmas com pontuação NAS > 50,00, destacando-se a UTI de trauma o que caracterizou-se com maiores escores 72,00 e 71,3.Conclusão: Em grande parte das pesquisas, a média de profissionais de enfermagem calculada pelo NAS é superior à média de profissionais requerida pela legislação. Observou-se que mesmo em UTIs com a mesma especificidade pôde-se perceber grandes diferenças na média do escore NAS, dessa forma, entendemos que apesar de possuir a mesma especificidade, o perfil do paciente assim como o da instituição tem suas particularidades demandando tempo de assistência diferente e consequentemente divergências no dimensionamento.

The main outcome measurements were morphometric analysis performed using a computer program, hematologic or biochemical change, and photography (predominant). It is unclear which was the most effective treatment for vitiligo, however, it was found that these therapies are all promising in the treatment of the disease. With proper care, disease control and repigmentation, even if partial, can be achieved.

In conclusion, we found significant advancement in this field of research, demonstrating the growing interest of academic and industrial groups in developing successful products for the treatment of vitiligo. New therapeutic options could contribute to improving the quality of life of patients and advance the search for a truly effective treatment of vitiligo.