Synthetic drugs for the treatment of vitiligo: a patent review (2010–2015)

Menezes, Andreia Freire de; Saravanan, S.; Gomes, Isla Alcântara; Carvalho, Fernanda Oliveira de; Quintans‐Júnior, Lucindo José; Gurgel, Ricardo Queiróz; Silva, Bruno de Santana; Serafini, Mairim Russo; Araújo, Adriano Antunes de Souza

doi:10.1080/13543776.2016.1215434

Cited by 10 publications

(6 citation statements)

References 39 publications

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“…Currently available treatment options for diabetes mellitus are achieved through oral hypoglycemic agents (metformin, sulfonylureas, and thiazolidinediones), insulin therapy, dietary guidance, and regular physical activity [7,8]. Unfortunately, their use is limited by adverse effects including gastrointestinal disorders, hypoglycemia, pancreatic degeneration, liver damage in the body [9], failure to achieve glycemic control, a different drug response among individuals [8,10] and cardiovascular disorders [9].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

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Plants are known to possess relatively high efficacy in the treatment of several chronic diseases with fewer adverse effects. In the recent years, numerous medicinal plants have been reported to be effective in treating diabetes. Hence, the present study aims to evaluate the antidiabetic property of hydroalcoholic extract of Hibiscus sabdariffa (HS) calyces in diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg/kg, b.w), in male Wistar rats. Diabetic rats were administered daily oral doses of HS (100, 200 and 400 mg/kg body weight) and Glibenclamide (10 mg/kg) for 21 days. Then, blood glucose levels, oral glucose tolerance test and lipid profiles were determined. Treatment with HS resulted in a significant dose dependent reduction of blood glucose levels accompanied by a significant improvement in body weight. The extract also enhanced the glucose tolerance and significantly decreased cholesterol, triglycerides, and low-density lipoproteins levels while the high-density lipoproteins level significantly increased. From the results obtained, it can therefore be concluded that Hibiscus sabdariffa has an antidiabetic effect in alloxan-induced diabetic rats.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

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“…3 The treatment of vitiligo, despite many available options, is still a challenge because of numerous reported relapses or incomplete re-pigmentation. 13,14 The main characteristic of vitiligo is presence of asymptomatic depigmented macules or patches with sharp margins caused by the destruction of melanin and melanocytes of the skin. 15 Although the exact cause of vitiligo is obscure, three proposed pathogenetic mechanisms include the immune hypothesis (melanocyte dysfunction or destruction due to the immune surveillance defect), the neural hypothesis (destroying melanocytes or inhibiting melanin production by a neurochemical mediator), and the selfdestruction hypothesis (melanocyte abnormalities caused by an intermediate or metabolite of melanin production).…”

Section: Introductionmentioning

confidence: 99%

“…The treatment of vitiligo, despite many available options, is still a challenge because of numerous reported relapses or incomplete re‐pigmentation 13,14 . The main characteristic of vitiligo is presence of asymptomatic depigmented macules or patches with sharp margins caused by the destruction of melanin and melanocytes of the skin 15 …”

Section: Introductionmentioning

confidence: 99%

The role of cytokines and vitamin D in vitiligo pathogenesis

Beyzaee

Goldust

Patil

et al. 2022

J of Cosmetic Dermatology

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Vitiligo is a pigment-related disease with a global prevalence of 0.2% to 1.8% associated with considerable burden on quality of life. The treatment is still a challenge because of relapses and/or incomplete re-pigmentation. Although the exact cause is still unclear, its pathogenesis seems to be justifiable with the autoimmune theory, supported by the results of clinical research. In this narrative review, we aimed to summarize the evidence related to cytokines and vitiligo development. This review is consisted of English articles published in PubMed and Google Scholar concerning levels of inflammatory mediators, especially interleukins, in vitiligo patients over the last 20 years. References of relevant articles were also considered for review. Crucial role of dysregulated levels of interleukins and their synergistic function to each other, in the onset or progression of the disease is evident. The theory of autoimmune vitiligo is reinforced by the results of the studies in the literature, due to the association of pathogenesis with increased secretion of pro-inflammatory mediators and reduction of anti-inflammatory mediators. Decreased vitamin D levels may have a considerable role in vitiligo development by affecting Th1-and Th17-related immune responses.Cytokines play an important role in the pathogenesis or progression of the disease. Moreover, we believe that decreased vitamin D level has a considerable role in vitiligo development by affecting Th1-and Th17-related immune responses.

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“…Current therapeutic drugs of vitiligo focus on skin repigmentation in a way of phenotypic intervention, such as immunomodulators (glucocorticoids) and calcineurin inhibitors (tacrolimus and pimecrolimus) ( Iannella et al, 2016 ). However, these drugs are not satisfactory to many patients because of time-consuming and adverse reactions ( Picardo et al, 2015 ; de Menezes et al, 2016 ; Iannella et al, 2016 ). One possible reason is that these therapeutic drugs are single-target treatments, rather than multi-target strategy under the network pharmacology ( Hopkins, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods

et al. 2021

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Vitiligo is a complex disorder characterized by the loss of pigment in the skin. The current therapeutic strategies are limited. The identification of novel drug targets and candidates is highly challenging for vitiligo. Here we proposed a systematic framework to discover potential therapeutic targets, and further explore the underlying mechanism of kaempferide, one of major ingredients from Vernonia anthelmintica (L.) willd, for vitiligo. By collecting transcriptome and protein-protein interactome data, the combination of random forest (RF) and greedy articulation points removal (GAPR) methods was used to discover potential therapeutic targets for vitiligo. The results showed that the RF model performed well with AUC (area under the receiver operating characteristic curve) = 0.926, and led to prioritization of 722 important transcriptomic features. Then, network analysis revealed that 44 articulation proteins in vitiligo network were considered as potential therapeutic targets by the GAPR method. Finally, through integrating the above results and proteomic profiling of kaempferide, the multi-target strategy for vitiligo was dissected, including 1) the suppression of the p38 MAPK signaling pathway by inhibiting CDK1 and PBK, and 2) the modulation of cellular redox homeostasis, especially the TXN and GSH antioxidant systems, for the purpose of melanogenesis. Meanwhile, this strategy may offer a novel perspective to discover drug candidates for vitiligo. Thus, the framework would be a useful tool to discover potential therapeutic strategies and drug candidates for complex diseases.

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Synthetic drugs for the treatment of vitiligo: a patent review (2010–2015)

Cited by 10 publications

References 39 publications

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

The role of cytokines and vitamin D in vitiligo pathogenesis

Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods

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