Use of extracts of sunflower-seed oil (Helianthus annus L.) for the treatment of cutaneous injuries in equine metatarsus: a case report

Coelho, Clarisse Simões; Gama, J.A.N.; Júnior, Lopes; Silva, B.S.F.; Souza, Vinicius Ricardo Cuña de; Endringer, Denise Coutinho; Lenz, Dominik

doi:10.1590/s1516-05722012000100018

Cited by 8 publications

(4 citation statements)

References 17 publications

(1 reference statement)

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“…A study 40 concluded that sunflower oil provides an increase in granulation tissue and complete healing of the epidermis. In other studies [41][42][43] , it was stated that sunflower oil was more effective in wound healing compared to control, and this may be due to the linoleic acid content. In our study, histological results were compatible with the literature, but when the immunohistological results were examined, it was seen that the sunflower oil group had high IL-6 and TNF-α in the wound tissue.…”

Section: The Success Ranking Of Groups At the End Of Experiments In A...mentioning

confidence: 93%

Effect of oral use of various edible oils on wound healing in rats: randomized controlled experimental study

Kafadar¹,

Büyükuslu²,

Kolbaşı³

et al. 2022

actapharm

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Section: The Success Ranking Of Groups At the End Of Experiments In A...mentioning

confidence: 93%

Effect of oral use of various edible oils on wound healing in rats: randomized controlled experimental study

Kafadar¹,

Büyükuslu²,

Kolbaşı³

et al. 2022

actapharm

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“…In a study by Oliveira et al (2013), it was found that pumpkin oil increased tensile strength and increased collagen synthesis, possibly as a result of the action of fatty acids (Oliveira et al, 2013). The sunflower seed oil has positively contributed to wound healing (Coelho et al, 2012;Rodrigues et al, 2004). Oleic and linoleic acids, the main components of sunflower oil, also present in extra virgin coconut oil, demonstrated that when topically applied, promoted rapid and satisfactory healing in mice (Cardoso et al 2004).…”

Section: Vehicles For the Use Of Ozone Therapymentioning

confidence: 99%

Clinical Uses and Molecular Aspects of Ozone Therapy: A Review

Pivotto¹,

Banhuk²,

Staffen³

et al. 2020

OnLine Journal of Biological Sciences

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Ozone was discovered over a hundred years ago and since then, it has been widely used in many areas, with the primary use as a disinfectant in various ways, but with applications in diverse conditions. More recently, the use of ozone has extended to other fronts, using it to treat different pathologies. Extensive studies have shown its effects, as well as the safety of its application in various modalities of use. Other studies showed its toxicity, which depends on the doses of use. Emerging evidence revealed that ozone also plays an important role in the wound healing and modulation of immune cells, describing the molecular pathways responsible for these actions and describing therapeutic actions in the treatment of wounds, pain, postoperative and infectious diseases. Ozone use has already been documented in different doses, forms of use and routes of application, depending on the clinical situation and an adaptation is necessary for a better result. Thus, this review summarizes the main clinical uses of ozone, presenting the molecular pathways responsible for its actions, as well as discussing the main routes of use, doses and, vehicles used in the clinic.

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“…Some topical preparations have already been tested in skin wounds in horses (MARTINS et al, 2003;SOUZA et al, 2006;COELHO et al, 2012.…”

Section: Introductionmentioning

confidence: 99%

Effects of topical application of pure and ozonized andiroba oil on experimentally induced wounds in horses

Araújo¹,

Teixeira²,

Lacerda³

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

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The aim of this study was to evaluate clinical and histopathological aspects of topical application of pure and ozonized andiroba oil (Carapa guianensis Aublet.) on the healing process of wounds in healthy horses. Eight 6.25 cm 2 wounds were surgically produced on each horse, from the cranial region to the sacrum, being four wounds on each side of the lumbar region. In three animals, left side was used for macroscopic observations and area measurement and right side was used for histopathological analysis. For the other two animals, evaluations were inverted. The beginning of the topical treatment occurred 12 hours after surgical induction of the injuries and was maintained daily until complete healing of the wounds, using saline solution (GC), ozonized saline solution (GO) sequentially and bilaterally in the craniocaudal direction, pure andiroba oil (GAP) and ozonized andiroba oil (GAO). Randomly, the sequence of the treatments was modified. Macroscopic and histopathological analyses were performed at 3, 7, 14, and 21 days after surgery. The time for complete healing of all wounds was recorded. A wound contraction of 67.75% for GC, 65.26% for GO, 67.91% for GAP, and 69.84% for GAO were recorded. Histopathologic evaluation revealed that wounds from the GAO and GAP had an advanced epithelialization, fibroblast proliferation and collagen deposition, moderate vascular proliferation, and presence of PMN infiltrate and discrete viewing of MN. It was possible to conclude that all treatments had benefits when comparing to control group, concluding that both pure and ozonized andiroba oil may be good options for treating wounds in horses. Keywords: Carapa guianensis. Healing process. Equines. Wounds. Ozone. ResumoEste trabalho realizou uma avaliação clínica e histopatológica da aplicação tópica do óleo de andiroba (Carapa guianensis Aublet), puro e ozonizado, no processo de cicatrização de feridas em cinco equinos saudáveis. Oito feridas de 6,25 cm 2 foram induzidas cirurgicamente, quatro de cada lado da região lombar, craniais em relação à região sacral. Em três animais, o lado esquerdo foi destinado à avaliação macroscópica e mensuração de área, enquanto o lado direito foi destinado à análise histopatológica. Nos outros dois animais, as avaliações foram invertidas. O tratamento tópico foi iniciado 12 horas após a indução cirúrgica e foi mantido diariamente até a completa cicatrização das feridas. Foram usados, sequencialmente e bilateralmente, no sentido craniocaudal: solução salina (GC), solução salina ozonizada (GO), óleo de andiroba puro (GAP) e óleo de andiroba ozonizado (GAO). Aleatoriamente, a sequência de tratamentos foi modificada. As análises macroscópicas e microscópicas foram realizadas 3, 7, 14 e 21 dias após a cirurgia, e o tempo total para cicatrização registrado. A contração da ferida foi de 67,75% para GC, 65,26% para GO, 67,91% para GAP, e 69,84% para GAO. A avaliação histopatológica demonstrou que as feridas tratadas com GAO e GAP apresentaram uma avançada epitelização, proliferação fibroblás...

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Use of extracts of sunflower-seed oil (Helianthus annus L.) for the treatment of cutaneous injuries in equine metatarsus: a case report

Cited by 8 publications

References 17 publications

Effect of oral use of various edible oils on wound healing in rats: randomized controlled experimental study

Effect of oral use of various edible oils on wound healing in rats: randomized controlled experimental study

Clinical Uses and Molecular Aspects of Ozone Therapy: A Review

Effects of topical application of pure and ozonized andiroba oil on experimentally induced wounds in horses

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