Avaliação da atividade antiinflamatória do coentro (Coriandrum sativum L.) em roedores

Abstract

RESUMO:Coriandrum sativum L. (Umbelliferae), conhecido popularmente por coentro, é uma planta doméstica cultivada nas diversas partes do mundo, inclusive no Brasil. As folhas e frutos do coentro são utilizados como condimento em culinária e na medicina popular como analgésica, antirreumática, carminativa e colagoga. O objetivo deste estudo foi avaliar o efeito do tratamento com o óleo essencial (OEC) e o extrato hidroalcóolico (EHC) do coentro em modelos experimentais de inflamação em roedores. A atividade antiinflamatória do coentro foi avaliada por meio dos testes de pleurisia em ratos e formação do edema de orelha em camundongos. A pleurisia foi induzida pela carragenina em animais tratados ou não com EHC. O edema de orelha induzido pela aplicação tópica de óleo de cróton e a atividade da mieloperoxidase foi avaliada em camundongos tratados ou não com OEC ou EHC. No teste da pleurisia o tratamento com EHC promoveu significativa diminuição no edema pleural, mas não sobre a migração leucocitária. Além disso, diferentemente ao observado com o tratamento com OEC, o uso tópico de EHC diminui significativamente o edema de orelha e a migração celular induzidos pela aplicação do óleo de cróton. Os dados indicam que EHC apresenta atividade antiinflamatória quando administrado pelas via oral e tópica, enquanto que OEC não apresenta atividade antiinflamatória tópica. Palavras-chave:Coriandrum sativum L., inflamação, pleurisia, edema de orelha, plantas medicinais ABSTRACT: Evaluation of the anti-inflammatory activity of coriander (Coriandrum sativum L.) in rodents. Commonly known as coriander, Coriandrum sativum L. (Umbelliferae) is a home plant grown in several parts of the world, including Brazil. Its leaves and fruits have been used as condiment in cooking and in folk medicine as analgesic, antirheumatic, carminative and cholagogue. The aim of this study was to evaluate the effect of essential oil (EO) and hydroalcoholic extract (HE) from coriander on experimental inflammation models in rodents. Coriander anti-inflammatory activity was evaluated by pleurisy tests in rats and ear edema formation in mice. Pleurisy was induced by carrageenan in HE-treated or non-treated animals. The ear edema was induced by topical application of croton oil and the myeloperoxidase activity was evaluated in EO-treated and HE-treated or non-treated mice. In the pleurisy test, HE treatment significantly decreased pleural edema but not the leukocyte migration. Furthermore, differently from EO, the topical use of HE significantly decreased ear edema and cell migration induced by croton oil application. The results indicate that HE had anti-inflammatory activity when orally and topically administered, whereas EO did not present topical anti-inflammatory activity.

Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

“…As expected, animals from control group and treated with placebo showed significant changes in the tissue morphology when compared with naive mice (Figures 4B and C). The connective tissue in the dermis presented lower amount of extracellular matrix due to the increase in cell number that migrated to the injured site, which was approximately 4 folds greater than the naive mice, corroborating with the data obtained in MPO assay (Zanusso-Junior et al, 2011). No significant difference was found in the number and morphology of sebaceous glands, hair follicles and blood vessels, when compared to the naive group ( Figure 4A).…”

A Review on Various Formulation of Nanoemulsions in Cosmetics With Plant Extracts as the Active Ingredients

“…Then after being injected all four hours later, the mice were sacrificed and their thickness measured (mm) and considered to assess the edema mass (mg). In both methods, the thickness values for the right ear were discounted from the right ear against all groups and the comparison to control was negative [51].…”

In Vitro and In Vivo Evaluation of Nanoemulsion Containing Vegetable Extracts

“…Then, ear circles of 6 mm were cut out and weighed on an analytical balance, to assess the intensity of mass edema (mg). In both methods, thickness and weight values for the right ears were discounted from the opposite side ears in all groups, and converted to a percentage, relative to the negative control [10,11].…”

“…The main compound present in the croton oil (Croton tiglium) that acts as an inflammatory agent is 12-O-tetradecanoylphorbol-13-acetate (TPA). The application of the oil results in rapid accumulation of inflammatory cells, such as neutrophils and macrophages, to produce reactive oxygen species at the site [11].…”