2015
DOI: 10.1590/s0102-865020150120000004
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Abstract: PURPOSE:To evaluate the effect of the Chenopodium ambrosioides L (mastruz) extract for preventing bone loss and bone metabolism in ovariectomized rats. METHODS:Twelve rats were subjected to bilateral ovariectomy for inducing osteoporosis. After surgery, they were divided into two groups: Ovariectomy-control group (G1, n=6), receiving 0.5 ml distilled water by gavage for 30 days, and Ovariectomy plus mastruz group (G2, n=6), receiving 0.5 ml of the hydroalcoholic extract of mastruz at 10% concentration (50mg) d… Show more

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Cited by 20 publications
(15 citation statements)
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“…Although, the SM Group showed a statistically higher level of osteoclastic activity when compared with the BC Group in time interval of 10 days ( p = .004); the level of endosteal bone formation was shown to be significantly higher for the SM Group in comparison with the BC Group in the same time period ( p = .025), which demonstrated small areas of localized and short‐term osteoclast activity. According to some authors (Nuttall et al, ; Soares et al, ), a possible mechanism of action of Mastruz could be the activation of osteogenesis and suppression of adipogenesis and osteoporosis, which would imply a higher number of osteoblasts, and consequently a higher level of bone formation.…”
Section: Discussionmentioning
confidence: 99%
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“…Although, the SM Group showed a statistically higher level of osteoclastic activity when compared with the BC Group in time interval of 10 days ( p = .004); the level of endosteal bone formation was shown to be significantly higher for the SM Group in comparison with the BC Group in the same time period ( p = .025), which demonstrated small areas of localized and short‐term osteoclast activity. According to some authors (Nuttall et al, ; Soares et al, ), a possible mechanism of action of Mastruz could be the activation of osteogenesis and suppression of adipogenesis and osteoporosis, which would imply a higher number of osteoblasts, and consequently a higher level of bone formation.…”
Section: Discussionmentioning
confidence: 99%
“…In dentistry, medicinal plants with therapeutic properties have motivated recent studies (Matos, ; Soares et al, ; Sousa, ; Souza, Oliveira, & Nicolete, ).…”
Section: Introductionmentioning
confidence: 99%
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“…Chenopodium ambrosioides promotes activation of osteogenesis implying a larger number of osteoblasts, and consequently, greater bone formation in rats submitted to anti‐osteoporotic therapy . This could explain the return of bone density to normality (Figure ).…”
Section: Discussionmentioning
confidence: 99%
“…The main risk factor is estrogen deficiency; thus, this disease is more common in women. Osteoporosis is characterized by the substantial reduction of bone mass and development of more porous and thin bones, extremely fragile, compromising bone strength and subjecting them to fracture 2,3 . A deficiency of the hormone results in a high rate of bone remodeling, in which the resorption formation exceeds formation, thus resulting in a body bone mass loss 4,5 .…”
mentioning
confidence: 99%