Anti-arthritic properties of crude extract from Chenopodium ambrosioides L. leaves

Abstract

HCE5 presented anti-arthritic potential and reduced IL-6 and TNF-α, which participate directly in the development and maintenance of the inflammatory process in rheumatoid arthritis.

Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

“…Leaf hydroalcoholic crude extracts significantly (p < 0.01) improved bone density by 34.5% and 34.8% at the knee and heel, respectively. Moreover, the bone architecture appeared completely preserved in collagen-induced arthritis male DBA1/J mice [251].…”

Edible Leafy Plants from Mexico as Sources of Antioxidant Compounds, and Their Nutritional, Nutraceutical and Antimicrobial Potential: A Review

“…The results showed that the fermented juice of P. oleracea decreases the production of intracellular ROS, preserves the integrity of monolayers of Caco-2 cells with inflammatory stimuli and limits the production of proinflammatory mediators such as prostaglandin E2 via cyclooxygenase enzymes and nitric oxide via iNOS, IL-8 and MCP-1. As with dietary fiber, the fermented juice of P. oleracea has the ability to preserve the integrity of the intestinal barrier, thus counteracting intestinal inflammation and oxidative damage [ 95 ].…”

“…The results indicate that these extracts reduce the percentage of neutrophils and macrophages and the number of bone marrow cells and increase the number of lymphocytes and cells in inguinal lymph nodes. This treatment reduces the serum concentration of proinflammatory cytokines (IL-6 and TNF-α), which cause the destruction of joints; consequently, the extract of C. ambrosioides protects joints by delaying bone density loss and cartilage and bone deformities [ 95 ]. C. ambrosioides has also been studied as an antifertility or contraceptive agent.…”

“…The leaves and young stems of quelites have functional compounds such as phenolic acids, flavonoids (isoquercitrin, nicotiflorin, rutin, 4-hydroxybenzoic acid, syringic acid, vanillic acid), ascorbic acid, betanin, amaranthine, iso-amarathine, betacyanins and other compounds recorded previously, whose current initiatives are evaluated by extracts or infusions of quelites, assumed to be a complex of compounds, to assess their beneficial effect in preventing metabolic syndrome [83,84], cancer, rheumatoid arthritis [95], chronic inflammatory disease, systemic joint disorders leading to joint damage and structural bone damage [100,101]. Furthermore, they have prophylactic potential against brain damage and neurodegenerative diseases related to oxidative and gastrointestinal stress [90,99].…”