Biocompatibility and osteogenesis of the castor bean polymer doped with silica (SiO2) or barium titanate (BaTiO3) nanoparticles

Abstract

PURPOSE:To evaluate the biocompatibility and osteogenesis of castor oil polymer doped with SiO 2 or BaTiO 3 nanoparticles. METHODS:Twenty four male rats Wistar were submitted to bone defect filled with castor oil polymer. The animals were distributed in RESULTS:The implants were biocompatible and allowed for progressive osteogenesis through osteoconduction in both observation periods. There was significant bone neoformation at 30 and 60 days in both groups within the histomorphometric evaluation, but group 1's osteogenesis was lesser in the 30 and 60-day periods observed when compared to the animals of group 2. The MEV morphometric evaluation evidenced a lesser percentage of osseous tissue filling within the BaTiO2-doped polymer. CONCLUSION:The castor oil polymer doped with SiO2 or BaTiO3 remained biocompatible and allowed for progressive osteogenesis in both observation periods.

Silicone Oil–Associated Extensive Intraocular Ossification: A case report

“…Because of the osteoinductive property of SiO 2 , SiO 2 nanoparticle was doped in biomaterial to promote bone formation. 13 We also noticed that our patient presented band keratopathy, which is recognized as one of the complications associated with SO. The histopathology of SO-induced keratopathy includes superficial stromal calcification and vascularization, which is consistent with our patient.…”

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

“…As also suggested by the results of Nacer et al 21 , the adhesion and growth of bone tissue depends on the surface regularity. Fibroblasts seem to avoid the rough surfaces and accumulate in smoother regions.…”

Castor polyurethane used as osteosynthesis plates: microstructural and thermal analysis

“…The surface characteristics corroborate with the results obtained by Monteiro et al [20] , who analyzed the ultrastructure of polyurethane and membranes for bone regeneration, and it was observed a flat and homogeneous surface, protrusions and depressions with an irregular outline, besides granular structures of various sizes. Nacer et al [6] and Marano and Tincani [21] state that the porous surface of the castor oil polymer promotes bone migration and deposition, behaving as a passive structure that allows osteoconduction.…”

“…The biocompatibility of resorbable polymers for fracture fixation is well established, but most of them hold high prices. The applicability of a biomaterial in the medical and dental area depends on its mechanical characteristics, biodegradation and microstructure features [6] . The study of castor oil polymer and hydroxyapatite/castor oil composite, a bone analog model, is justified by the possibility of local production of a resorbable biomaterial as an alternative in the treatment of facial fractures, with lower cost for use in the public service and also in pediatric patients.…”