Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Santos, Viviani Teixeira dos; Facco, Gilberto Gonçalves; Ortiz, Hudman Cunha; Silva, Iandara Schettert da

doi:10.1590/s0102-865020170204

Cited by 2 publications

(2 citation statements)

References 20 publications

(14 reference statements)

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“…Castor oil presents in its composition 89.5% to 90% triglyceride ricinoleic acid (12-hydroxy-cis-9-octadecenoic acid), whose molecular formula is C 17 H 32 OHCOOH. In the ester bonds of the triglyceride (1st carbon) reactions of hydrolysis, esterification, alcoholysis and, halogenation can occur (Figure 1) [9][10][11][12] .…”

Section: Castor Oil Catalysis and Physicochemical Characterizationmentioning

confidence: 99%

Castor polyurethane used as osteosynthesis plates: microstructural and thermal analysis

et al. 2019

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Bone fractures to be corrected need stabilization of their extremities, which is achieved with the use of plates and screws. This research aimed to produce castor bean polyurethane (Ricinus communis), to make resorbable plate, structural and thermal analysis. The production was made by the glycerolysis of the triglycerides present in the oil, after addition of polyol/glycerol and hexamethylene diisocyanate (HDI) to form urethane structures, with and without addition of hydroxyapatite. The characterization was by FTIR spectroscopy, scanning electron microscopy (SEM), X-ray diffraction, differential scanning calorimetry and thermogravimetry. Plates with dimensions of 40 mm X 10 mm X 2 mm were obtained. The SEM showed flat and homogeneous surface. DRX analysis showed the semi-crystallinity of the biomaterial. Glass transition and thermal stability up to 50 °C were observed, followed by thermal decomposition up to 450 °C. The produced polyurethane showed it is possible to be applied in the manufacture of plate.

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Section: Castor Oil Catalysis and Physicochemical Characterizationmentioning

confidence: 99%

Castor polyurethane used as osteosynthesis plates: microstructural and thermal analysis

et al. 2019

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“…Among the biomaterials used for scaffold synthesis, polymers stand out for having customizable physical-chemical properties and elastic mechanical properties [2,7]. In this context, castor oil (Ricinus communis L.), a euphorbia widely distributed in the Americas and southern Asia, has got the potential for the synthesis of natural polymers, for acting as a polyol, in addition to the low acquisition cost, wide availability, and easy processability [7,8]. Contemporary studies have already described its use for inducing bone neoformation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Development of castor polyurethane scaffold (Ricinus communis L.) and its effect with stem cells for bone repair in an osteoporosis model

Pacheco¹,

Reis²,

Carvalho³

et al. 2021

Biomed. Mater.

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The development of ‘smart’ scaffolds has achieved notoriety among current prospects for bone repair, especially for chronic osteopathy, such as osteoporosis. Millions of individuals in the world suffer from poor bone healing due to osteoporosis. The objective of this work was to produce and characterize castor polyurethane (PU) scaffolds (Ricinus communis L.) and evaluate its in vitro biocompatibility with stem cells and osteoinductive effect in vivo on bone failures in a leporid model of osteoporosis. The material was characterized using Fourier-transform infrared spectroscopy, thermogravimetric analysis, SEM, and porosity analysis. Then, the biocompatibility was assessed by adhesion using SEM and cytotoxicity in a 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium assay. The osteoinductive effect in vivo was determined in bone defects in rabbit tibias (Oryctolagus cuniculus) submitted to castor PU scaffold, castor PU scaffold associated with stem cells, and negative control, after four and eight weeks, evaluated by computed microtomography and histopathology. The scaffolds were porous, with an average pore size of 209.5 ± 98.2 µm, absence of cytotoxicity, and positive cell adhesiveness in vitro. All the animals presented osteoporosis, characterized by multifocal osteoblastic inactivity and areas of mild fibrosis. There were no statistical differences between these treatments in the fourth week of treatment. In the eighth week, the treatment with castor PU scaffold alone induced more significant bone formation when compared to the other groups, followed by treatment with an association between castor PU scaffold and stem cells. The castor PU scaffold was harmless to cell culture, favoring cell adhesiveness and proliferation, in addition to inducing bone neoformation in osteoporotic rabbits.

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Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Cited by 2 publications

References 20 publications

Castor polyurethane used as osteosynthesis plates: microstructural and thermal analysis

Castor polyurethane used as osteosynthesis plates: microstructural and thermal analysis

Development of castor polyurethane scaffold (Ricinus communis L.) and its effect with stem cells for bone repair in an osteoporosis model

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