Brazilian cerrado antioxidant sources: cytotoxicity and phototoxicity in vitro

Roesler, Roberta; Lorencini, Márcio; Pastore, Gláucia Maria

doi:10.1590/s0101-20612010000300038

Cited by 26 publications

(14 citation statements)

References 8 publications

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“…The exploitation of natural antioxidants has become increasingly important in recent years (Roesler et al, 2010). Pequi (Caryocar brasiliense) is a tree typical of the Brazilian cerrado, whose fruit is widely used in folk medicine.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effect of the pequi oil (Caryocar brasiliense) on the hepatic tissue of rats trained by exhaustive swimming exercises

et al. 2019

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Increased oxygen consumption and activation of specific metabolic pathways during or after physical exercise lead to the formation of reactive oxygen and nitrogen species. An investigation was made into the effects of pequi oil supplementation in protecting liver cells against injury resulting from oxidative stress. The experiments involved 20 male adult Wistar rats ( Rattus norvegicus). The animals were divided into four experimental groups: Group 1: sedentary control group; Group 2: exercise control group; Group 3: supplemented sedentary group; and Group 4: supplemented exercise group. Supplementation consisted of pequi oil administered by oral gavage (400 mg). The animals of the exercised groups were subjected to 20 swimming sessions for 5 weeks (with progressive increase of 10 minutes until exhaustion). Samples were collected from the right hepatic lobe for histopathological analysis and determination of malondialdehyde levels. The histopathological analyses revealed that the animals of the exercised control group had moderate liver damage, while the animals of the supplemented exercised group had slight tissue damage, and the sedentary control and sedentary supplemented groups showed no tissue damage. The malondialdehyde levels showed higher and statistically significant in exercise control group when compared to the other evaluated groups (p<0.05). In conclusion the supplementation with pequi oil had a protective effect on liver cells against damage caused by oxygen free radicals during strenuous exercise, as demonstrated by the indicator of lipid peroxidation.

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Section: Introductionmentioning

confidence: 99%

Antioxidant effect of the pequi oil (Caryocar brasiliense) on the hepatic tissue of rats trained by exhaustive swimming exercises

et al. 2019

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“…The genus Annona L. (Annonaceae) is empirically used for the treatment of inflammatory disorders, and our research group showed that extracts, fractions, and isolated compounds are anti-inflammatory natural agents (Formagio et al, 2013a,b). Fruits from this genus are widely used in the traditional herbal medicine, such as for herbal healing; however, their toxic and pharmacological effects on inflammatory states have not been scientifically investigated (Roesler et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of theAnnona crassifloramethanolic extract

Rocha

Kassuya

Formagio

et al. 2015

Pharmaceutical Biology

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“…Phototoxicity is an acute reaction that can be induced by single treatment with a chemical and ultraviolet (UV) or visible radiation. Photoirritation is used to describe phototoxic reactions in the skin due to topically-applied substances combined with light exposure [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the cytotoxicity and phototoxicity of Caryocar brasiliense supercritical carbon dioxide extract

Amaral

Moriel

Foglio

et al. 2014

BMC Complement Altern Med

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BackgroundCaryocar brasiliense Camb (Pequi) is a typical Brazilian Cerrado fruit tree. Its fruit is used as a vitamin source for culinary purposes and as a source of oil for the manufacture of cosmetics. C. brasiliense supercritical CO2 extracts exhibit antimicrobial activity against the bacteria Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus and also possess antioxidant activity. This study was designed to evaluate the in vitro cytotoxicity and phototoxicity of the supercritical CO2 extract obtained from the leaves of this species.MethodsIn vitro cytotoxicity and phototoxicity of C. brasiliense supercritical CO2 extracts were assessed using a tetrazolium-based colorimetric assay (XTT) and Neutral Red methods.ResultsWe found that the C. brasiliense (Pequi) extract obtained by supercritical CO2 extraction did not present cytotoxic and phototoxic hazards.ConclusionsThis finding suggests that the extract may be useful for the development of cosmetic and/or pharmaceutical products.

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Brazilian cerrado antioxidant sources: cytotoxicity and phototoxicity in vitro

Cited by 26 publications

References 8 publications

Antioxidant effect of the pequi oil (Caryocar brasiliense) on the hepatic tissue of rats trained by exhaustive swimming exercises

Antioxidant effect of the pequi oil (Caryocar brasiliense) on the hepatic tissue of rats trained by exhaustive swimming exercises

Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of theAnnona crassifloramethanolic extract

Evaluation of the cytotoxicity and phototoxicity of Caryocar brasiliense supercritical carbon dioxide extract

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