2019
DOI: 10.1590/1519-6984.180015
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Antioxidant effect of the pequi oil (Caryocar brasiliense) on the hepatic tissue of rats trained by exhaustive swimming exercises

Abstract: Increased oxygen consumption and activation of specific metabolic pathways during or after physical exercise lead to the formation of reactive oxygen and nitrogen species. An investigation was made into the effects of pequi oil supplementation in protecting liver cells against injury resulting from oxidative stress. The experiments involved 20 male adult Wistar rats ( Rattus norvegicus). The animals were divided into four experimental groups: Group 1: sedentary control group; Group 2: exercise control group; G… Show more

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Cited by 17 publications
(12 citation statements)
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“…Our results are according to studies showing promising pequi activity with respect to the inhibition of pre-formed free radicals in vitro analyzed by the 2,2-diphenyl-1-picryl-hydrazyl-hydrate free radical scavenging method (DPPH assay) [5,19]. Moreover, pequi reduced lipid peroxidation in an in vivo aluminum-induced neurotoxicity and neuroinflammation model [46], in an exhaustive exercise-induced liver inflammation model [43], in liver in an atherosclerosis model [47], and in an urethane-induced lung tumor model [10].…”
Section: Discussionsupporting
confidence: 74%
See 1 more Smart Citation
“…Our results are according to studies showing promising pequi activity with respect to the inhibition of pre-formed free radicals in vitro analyzed by the 2,2-diphenyl-1-picryl-hydrazyl-hydrate free radical scavenging method (DPPH assay) [5,19]. Moreover, pequi reduced lipid peroxidation in an in vivo aluminum-induced neurotoxicity and neuroinflammation model [46], in an exhaustive exercise-induced liver inflammation model [43], in liver in an atherosclerosis model [47], and in an urethane-induced lung tumor model [10].…”
Section: Discussionsupporting
confidence: 74%
“…It is known that pequi medicinal use is directly related with its rich natural antioxidant composition, including oleic acid, and represents an alternative therapy for oxidative stress conditions [38,43]. Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense mechanisms, sometimes leading to tissue damage [44].…”
Section: Discussionmentioning
confidence: 99%
“…Another study, carried out by Vale et al (2018), verified the effect of C. brasiliense pulp extract, orally (400 mg, five times a week, for 4 weeks) on the liver of Wistar rats submitted to strenuous swimming sessions. It was observed that pequi oil acted as an antioxidant, reducing tissue damage caused by free radicals during strenuous exercise, acting as a liver protector, forming a barrier against other harmful metabolic processes, such as necrosis, fibrosis, steatosis, and cirrhosis.…”
Section: Antioxidant Activitymentioning
confidence: 94%
“…In this context, in Brazil, there are several medicinal plants that are used as herbal medicines by the rural and urban populations (Dutra et al, 2016;Pio et al, 2019). A single species can produce numerous chemical compounds with diverse pharmacological activities (Mendonça et al, 2019), including antibacterial (Pandini et al, 2018;Emre et al, 2020;Pacheco et al, 2020), anti-inflammatory (Ribeiro et al, 2018;Almohawes and Alruhaimi, 2020), antioxidant (Barth et al, 2018;Pontes et al, 2019;Vale et al, 2019), wound-healing properties (Ribeiro Neto et al, 2020), antihyperglycemic effect (Silva et al, 2020), and cardiovascular activity (Moreira et al, 2019).…”
Section: Introductionmentioning
confidence: 99%