A fitoterapia no mundo atual

Ferreira, Vı́tor F.; Pinto, Ângelo C.

doi:10.1590/s0100-40422010000900001

Cited by 52 publications

(42 citation statements)

References 2 publications

(2 reference statements)

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“…21 The carbon signals at δ 178.43 (C2) and at δ 213.58 (C21) were attributed to carbonyl carbons. The chemical shift values found in the 13 C NMR spectrum of terpene 5 were consistent with the literature data. 23 The IR spectrum of 6 revealed bands at 1592 and 1458 cm -1 that were associated to the C=C bond of aromatic compound.…”

Section: Phytochemical Studysupporting

confidence: 90%

“…The carbon signals at δ 187.94 (C6) and at δ 214.69 (C21) were associated to carbonyls. The chemical shift values found in the 13 C NMR spectrum of terpene 6 were consistent with the literature data. 24 …”

Section: Phytochemical Studysupporting

confidence: 90%

“…The chemical structures of these constituents were identified based on IR, 1 H and 13 C NMR spectral data, and by comparing with literature data. Compound 1 was previously isolated through phytochemical study of the aerial part of M. imbricata.…”

Section: Phytochemical Studymentioning

confidence: 99%

“…Indeed, around 50% of drugs approved by the Food and Drug Administration (FDA) between 1981 and 2006 were of natural origin. 13 It has been reported that the molecular diversity of natural products is higher than those derived from chemical synthesis processes. Thus, the biological assays of natural products represent a continuing source of new structural models for compounds with antimicrobial properties and are an important alternative for reducing the incidence of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Rodrigues¹,

Duarte²,

Silva³

et al. 2012

Quím. Nova

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Recebido em 3/10/11; aceito em 26/2/12; publicado na web em 2/7/12The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1 H and 13 C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.

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Section: Phytochemical Studysupporting

confidence: 90%

Section: Phytochemical Studysupporting

confidence: 90%

Section: Phytochemical Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Rodrigues¹,

Duarte²,

Silva³

et al. 2012

Quím. Nova

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“…1 However, during the second half of the twentieth century, especially in the Western world, herbal medicines were gradually replaced by allopathic medicines. Allopathic treatments are currently more widely used than traditional medicines, especially in developed countries.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology-based drug delivery systems and herbal medicines: a review

Bonifácio¹,

Silva²,

Ramos³

et al. 2013

IJN

248

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Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.

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