Alcalóides de flores e folhas de Erythrina speciosa Andrews

Abstract

Recebido em 14/12/05; aceito em 4/8/06; publicado na web em 10/1/07 ALKALOIDS FROM FLOWERS AND LEAVES OF Erythrina speciosa ANDREWS. In vitro bioassays with leave extracts of Erythrina speciosa showed promising activity against Trypanosoma cruzi. From the flowers of E. speciosa two alkaloids were isolated: erysotrine and erythartine. The leaves furnished one alkaloid, nororientaline. The structures were determined on the basis of spectroscopic evidence. This is the first report about the investigation of alkaloids in flowers and leaves of this species, as well the first report of nororientaline occurrence in this plant.Keywords: Erythrina speciosa; alkaloids; trypanocidal activity. INTRODUÇÃOOs extratos de folhas, cascas e de raízes de várias espécies do gênero Erythrina são usados na medicina popular no tratamento de diversas doenças, tais como disenteria, asma, dor estomacal, infertilidade feminina e, principalmente, infecções microbianas. O gênero é conhecido pela bioprodução significativa de alcalóides, sendo que estudos mais recentes revelaram também a presença de flavanonas, isoflavonas e pteropcarpanos , o que serviu como estímulo adicional para iniciar atividades de investigação química da espécie.O presente trabalho descreve o isolamento e a caracterização estrutural dos alcalóides erisotrina (1) e eritrartina (2) obtidos do extrato etanólico das flores e da nororientalina (3), do extrato etanólico das folhas de E. speciosa. A literatura registra o isolamento de alcalóides de sementes e cascas de E. speciosa 2,10,11 , porém este é o primeiro registro de estudo de flores e folhas desta espécie. RESULTADOS E DISCUSSÃOO fracionamento cromatográfico do extrato etanólico das flores de E. speciosa forneceu um grupo de frações eluídas com uma mistura de diclorometano/etanol 10%, que revelou teste positivo com reagente de Dragendorff, sugerindo a presença de substância nitrogenada. A purificação deste material resultou no isolamento e posterior identificação dos alcalóides erisotrina (1) e eritrartina (2) .

Antimicrobial activity of Brazilian plants of the genera Leguminosae and Myrtaceae

“…More recently, however, pentacyclic triterpenes, Daniel et al 961 glycosylated flavonoids, gallic acid, and ellagic acid were also isolated (Paula et al, 2012). The alkaloid nororientaline was isolated from E. speciosa leaves (Faria et al, 2007), and the extract was studied in this work. A further two alkaloids, erysotrine and erythartine, were described by Faria et al (2007), and were isolated from the flowers of this plant.…”

“…The phytochemical analysis of all the plants cited earlier were previously reported by Custódio (2009), Faria et al (2007, Martinez et al (2012), Rieger (2011), andBurgo (2010). All the results obtained herein are described for the first time with P. pseudocaryophyllus stems, E. speciosa leaves, T. toxicaria roots, and C. leptophylla leaf extracts, as well as the toxicity and antifungal assays using Lasiodiplodia theobromae, Botryosphaeria ribis, Botryosphaeria rhodina and Fusarium verticillioides with the P. pseudocaryophyllus and I. marginata leaf extracts are also described.…”

“…The alkaloid nororientaline was isolated from E. speciosa leaves (Faria et al, 2007), and the extract was studied in this work. A further two alkaloids, erysotrine and erythartine, were described by Faria et al (2007), and were isolated from the flowers of this plant. Moreover, other species showed the presence of alkaloids (Folkers and Koniuszy, 1940;Folkers et al, 1941;Soto-Hernandez and Jackson, 1994;Chacha et al, 2005;Cui et al, 2009).…”

“…This plant has also been described to treat ailments, dysentery, asthma, indigestion, and female infertility as folk medicine (Mitscher et al, 1987;Soto-Hernandez and Jackson, 1994;Saidu et al, 2000;Kone et al, 2011). Alkaloids and flavonoids are plant secondary metabolites described in various species of this genus (Sarragiotto et al, 1981;Nkengfack et al, 1997;Faria et al, 2007;Amir et al, 2011).…”

Constituents of Erythrina - a Potential Source of Secondary Metabolities: A Review

“…Erythrina is a prominent source of alkaloid. A bunch of alkaloids are isolated from these fifteen species of Erythrina such as -Erysovine-N-oxide (1), Erysosalvinone (2), Erysodine (3), 1H-indole-3-propanamide (4), Glucoerysodine (5), Erysotrine (6), Erysovine (7), Erythraline (8), Erythramine (9), Erysopine (10), Erythrocarine (11), Erythrinine (17), 10, 11-Dioxyerysotrine (34), Erysosalvine (41), Erymelanthine (43) (Amer et al, 1991;Boland et al, 1998;Cui et al, 2009;Faria et al, 2007;Garin-Aguilar et al, 2000;Haggins et al, 1981;Hauschild et al, 2010;Hussain, 2002;Jang et al, 2008;Kabenei et al, 2011;Kumar et al, 2010;Soto-Hernadez et al, 2012;Lundquist, 1973;Miyazawa et al, 2006;Nakayama et al, 1978;Ozawa et al, 2011;Rodriguez et al, 2004;Watjen et al, 2008;Rahman et al, 2007;Rahman et al, 2010;Rodriguez et al, 2004;Rukachaisirikul et al, 2008;Soto-Hernadez et al, 2012;Tanaka et al, 2001;Wanjala et al, 2002;Zheng et al, 2013;Zhou et al, 2011). (Boland et al, 1998;Chacha et al, 2005;Hussain et al, 2008;Hussain et al, 2011;Jang et al, 2008;Kobayashi et al, 1997;Koo et al, 2013;Kumar et al, 2010;Lundquist, 1973;…”