Constituents of Erythrina - a Potential Source of Secondary Metabolities: A Review

Hussain, Mohammad Musarraf; Tuhin, Tariqul Haque; Akter, Fatema; Rashid, Mohammad A.

doi:10.3329/bpj.v19i2.29287

Cited by 21 publications

(10 citation statements)

References 23 publications

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“…Hypaphorine is structurally similar to a number of biochemically active compounds such as the plant hormone indole-3-acetic acid (IAA), tryptophan, melatonin and seratonin [5][6][7] (Figure 1S) and therefore, it has been found to be of potential medicinal value [4,5]. It can act as a competitive inhibitor for a number of processes controlled by IAA [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Density functional theory studies of Hypaphorine from Erythrina mildbraedii and Erythrina addisoniae: structural and biological properties

et al. 2020

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This study was aimed at isolating hypaphorine from Erythrina mildbraedii Harms (Fabaceae) and Erythrina addisioniae Hutch. & Datziel (Fabaceae) in order to determine its structural and antibacterial effects. Density functional theory (DFT) calculations and X-ray crystallographic analysis of the isolated hypaphorine was determined. The antibacterial effects of hypaphorine against a number of Gram positive and Gram negative bacterial strains were investigated. The root mean square deviation between the experimental and calculated bond lengths and bond angles of hypaphorine were found to be 0.046 Å and 1.5° respectively. The highest occupied molecular orbital (HOMO) of hypaphorine was delocalised on the indole moiety whereas the lowest occupied molecular orbital (LUMO) was delocalised on the -N(CH 3 ) 3 group and the HOMO-LUMO gap of hypaphorine was 4.65 eV. Hypaphorine inhibited the growth of the Gram-positive bacteria tested, namely Bacillus cereus, B. subtilis, Staphylococcus aureus and S. epidermidis. The lowest minimum inhibitory concentration (MIC) value of 2 mg/mL was exhibited against Mycobacterium smegmatis, Staphylococcus aureus and B. subtilis. The theoretical and experimental results from this study showed that hypaphorine is capable of forming quadrupole moments thus explaining its antibacterial effects on Gram positive bacteria. Graphic abstractroot hair formation and stimulates curling of the roots which aids in these symbiotic relationships [7]. Hypaphorine has thus been detected in a number of ectomycorrhizal fungal species like Pisolithus tinctorius [1,11,12]. In these symbiotic relationships, hypaphorine inhibits the effect of IAA in the fungi by blocking membrane-bound IAA receptors thus inducing abnormal proliferation of hyphae that extend intracellularly into plant tissues.

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Section: Introductionmentioning

confidence: 99%

“…Erythrina is a prominent source of phytoconstituents and medicinal agents [9]. They are widely known for their symbiotic relationships with mycorrhizal fungi.…”

Section: Introductionmentioning

confidence: 99%

Density functional theory studies of Hypaphorine from Erythrina mildbraedii and Erythrina addisoniae: structural and biological properties

et al. 2020

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“…Some aspects about these alkaloids have already been reviewed such as synthetic approaches (Parsons & Palframan, ), chemical and pharmacological aspects of E. verna (syn. E. mulungu ; Patočka, ), and secondary metabolites of Erythrina species (Hussain, Tuhin, Akter, & Rashid, ), but to the best of our knowledge, a review on Erythrina ‐type alkaloids and their biological potential has not been recently published. For these reasons, the early 1990's publication still is the reference on Erythrina alkaloids (Amer, Shamma, & Freyer, ).…”

Section: Introductionmentioning

confidence: 99%

The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies

Rambo

Biegelmeyer

Toson

et al. 2019

Phytotherapy Research

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Erythrina L. genus (Fabaceae) comprises about 115 species, and it has been extensively studied, mainly because of its alkaloids, which have pharmacological properties. References demonstrated that Erythrina spp. have a potential to act in the central nervous system, presenting anxiolytic and anticonvulsant properties already established. Phytochemical investigations confirmed the presence of tetracyclic alkaloids as the major compounds. However, other alkaloid classes have also been reported, including dimeric and trimeric substances, coupled through direct polymerization or two erythrinine units via an acetyl glucose. The present review covers the relevant literature from 1990 until 2017 and outlines the current data on chemical composition and preclinical and clinical studies on Erythrina species. Additionally, the quite striking analogy in the biosynthetic route of erythrin, morphinans, and Amaryllidaceae family alkaloids was also discussed.

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“…Nature is a significant resource of medicinal plants and these plants are using as conventional agents for the treatment of various diseases from many years (Hussain 2019(Hussain , 2018Hussain et al, 2016aHussain et al, , 2016b. The medicinal plants under Acacia genus is bearing therapeutic properties such as antimicrobial, anti-inflammatory, anti-plasmodial, and cytotoxic activity (Billah et al, 2013;Hussain et al, 2011Hussain et al, , 2010Hussain et al, , 2008Ismail et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A Mini Review on the Chemical Compounds of the Genus Acacia

Hussain¹

2019

Bangla Pharma J

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The genus Acacia is a pioneering source of diversified chemical compounds. The purpose of this review is to compile of the phytochemicals from few species of Acacia. A total ten species of Acacia were studied and seventy six (1-76) phytoconstituents, including their chemical structures are reported in this review. The highest number of chemical compounds has been reported from Acacia nilotica. Bangladesh Pharmaceutical Journal 22(2): 235-242, 2019

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Constituents of Erythrina - a Potential Source of Secondary Metabolities: A Review

Cited by 21 publications

References 23 publications

Density functional theory studies of Hypaphorine from Erythrina mildbraedii and Erythrina addisoniae: structural and biological properties

Density functional theory studies of Hypaphorine from Erythrina mildbraedii and Erythrina addisoniae: structural and biological properties

The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies

A Mini Review on the Chemical Compounds of the Genus Acacia

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