Rabdomióilise secundária a acidente ofídico crotálico (Crotalus durissus terrificus)

Magalhães, Renato Almeida; Ribeiro, Maria Mônica Freitas; Rezende, Nilton Alves de; Amaral, Carlos Faria Santos

doi:10.1590/s0036-46651986000400004

Cited by 44 publications

(32 citation statements)

References 13 publications

(3 reference statements)

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“…Signs appeared in the first 48 hours after the ophidic accident but the patients did not present alterations in radiographs of the thorax. In spite of the absence of significant breathing alterations in the animals of the present study, it is necessary to emphasize that complications due to paralysis of the breathing musculature are important complications mentioned by other authors (2,12,17).…”

Section: Clinical Evaluationmentioning

confidence: 56%

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Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Nogueira¹,

Sakate²

2006

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The present work aimed to evaluate the clinical and hematological aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with different antiophidic serum doses. Sixteen dogs were divided into two groups of eight animals each. Group I received 1mg/kg venom subcutaneously and 30mg antiophidic serum intravenously; Group II received 1mg/kg venom subcutaneously and 60mg antiophidic serum intravenously. In the clinical evaluation, we observed ataxia, moderate sedation, dilated pupils, sialorrhea, flaccid paralysis of mandibular muscles, and discreet edema at the site of venom inoculation. Evaluating red and white blood cells, we observed a decrease of hemoglobins, globular volume and erythrocytes, and an increase of plasmatic proteins, leukocytes, neutrophils, monocytes and lymphocytes. Clotting time increased and there was blood incoagulability with return to normal clotting time six hours after antiophidic serum administration. Animals treated with six antiophidic serum flasks had a faster recovery than the animals that received three serum flasks.

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Section: Clinical Evaluationmentioning

confidence: 56%

“…The major complication observed in Crotalus accidents is the development of acute renal insufficiency with tubular necrosis (17,23).…”

Section: Introductionmentioning

confidence: 99%

Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Nogueira¹,

Sakate²

2006

J. Venom. Anim. Toxins incl. Trop. Dis

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“…The major complications observed in Crotalus envenomation are acute renal failure and tubular necrosis (23,28,33).…”

Section: R M B Nogueira Et Al Experimental Envenomation With Crotmentioning

confidence: 99%

Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram

Nogueira¹,

Sakate²,

Sangiorgio³

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The present study aimed at evaluating clinical and laboratory aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution (iv); and Group III received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution containing sodium bicarbonate diluted to the dose of 4mEq/kg. The clinical signs of ataxia, sedation, flaccid paralysis, mydriasis, eyeball paralysis, mandible ptosis, sialorrhea, vomiting and diarrhea observed in the dogs were very similar to those observed in humans. The decrease in hemoglobin, hematocrit, erythrocyte, platelet and fibrinogen levels, prolongation of clotting time, prothrombin time (PT) and activated partial thromboplastin time (APTT), as well as hypocellularity in the bone marrow characterized anemia, thrombocytopenia and blood incoagulability, as well as hypofibrinogenemia and decreased bone-marrow activity. Important bleeding was not observed. Increased numbers of leukocytes and neutrophils and decreased numbers of lymphocytes and eosinophils characterized an acute inflammatory response and stress caused by generalized pain. The employed antiophidic serum was effective and all animals survived.

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“…The myotoxic action promotes widespread myalgy and myoglobinuria (AzevedoMarques et al 1985, Magalhães et al 1986, Motta et al 2007.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Floriano

Nogueira

Sakate³

et al. 2009

RBT

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Abstract:Crotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant Mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M. glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M. glomerata in crotalic accidents. Rev. Biol. Trop. 57 (4): 929-937. Epub 2009 December 01.

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Rabdomióilise secundária a acidente ofídico crotálico (Crotalus durissus terrificus)

Cited by 44 publications

References 13 publications

Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram

Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

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