Hiperglicemia e doença cardiovascular podem coexistir

Chacra, Antônio Roberto; Alvarenga, Marcelo Alves

doi:10.1590/s0004-27302008000300001

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…Estimates show that the global number of T2DM patients will reach about 366 million in 2030 (1). T2DM leads to several macro and microvascular complications related to long-term damage and various organsystem failure (2). In this regard, several studies have indicated that T2DM triggers oxidative stress by the production of free radicals and a reduction in antioxidant status (3,4).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus

et al. 2021

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Background: Exercise is considered to improve metabolic markers in type 2 diabetics Mellitus (T2DM). In this regard, we compared in ammatory, antioxidant, and glycemic status to a different mode of highintensity interval training in patients with T2DM.Methods and Results: 59 T2DM patients (age= 45-60 yrs) were randomly divided to strength training (ST) (n=15), high intensity interval training (HIIT) (n=16), HIIT+ST (n=15) or served as control (CON) (n=13) groups. Experimental groups performed three training sessions/week for 12 weeks. Blood biochemistry and anthropometric parameters were evaluated at baseline and after the 12 weeks of interventions.All training protocols ameliorated antioxidant factors (total antioxidant capacity, glutathione peroxidase, superoxide dismutase, and malondialdehyde activities), lipid pro le (TC, TG, HDL and, LDL,) and glycemic parameters. Moreover, interleukin 6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) signi cantly decreased in three training groups; however, these change was more pronounced in the ST+HIIT group. As a result of training, the overall concentration of in ammatory and antioxidant status was improved signi cantly in all three groups than the CON group and baseline values (P≤ 0.05).Moreover, non-substantial differences were found among groups on and measured glycemic variables.Conclusions: Our results showed improvement in in ammatory factors, antioxidants, and glycolytic indices in all groups regardless of their type. However, for more bene ts in T2DM patients, combination exercises can be suggested.

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Section: Introductionmentioning

confidence: 99%

Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus

et al. 2021

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“…Lesão maior do que 70% e não obstruída 33,8% 2412,7% 919,7% (14) Artéria obstruída 28,2% 2025,4% 1811,3% (8)…”

Section: Discussionunclassified

“…Está presente em 25 a 50% dos pacientes admitidos com IAM. 8,9,[11][12][13][14][15] O conjunto de alterações a nível celular, tecidual e sistêmico (necrose celular, acidose celular e sistêmica, entre outros) provocado pela hiperglicemia explica a permanência prolongada no hospital e maior morbimortalidade. 15,16 O risco de complicações hospitalares em não diabéticos e diabéticos com IAM ocorreram com valores de glicemia, respectivamente, maiores que 110 e maiores ou iguais a 180 mg/dl no estudo de Góis e Capes e cols.…”

Section: Introductionunclassified

Relação dos níveis de glicemia e proteína C-reativa com o prognóstico de pacientes com infarto agudo do miocárdio com supradesnível do segmento ST / Relation of blood glucose and C-reactive protein levels to the prognosis of patients with acute myocardial infarction with ST segment elevation

Bueno

Cipullo

2018

Rev Cienc Saude

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Introdução: Pacientes com Infarto Agudo do Miocárdio (IAM) apresentam intensa resposta sistêmica ao insulto isquêmico, podendo evoluir com complicações que podem estar associadas ao valor de glicemia e proteína C-reativa da admissão. Objetivos: Avaliar a relação dos níveis glicêmicos e de proteína C-reativa com o prognóstico de pacientes internados com IAM com supradesnível do segmento ST. Métodos: Estudo retrospectivo e transversal, com análise de prontuários de pacientes que foram internados com diagnóstico de IAM com supradesnível do segmento ST no período de 1º março de 2016 a 28 de fevereiro de 2017 no Hospital Escola de Itajubá (MG, Brasil). Foram incluídos na análise 71 prontuários de pacientes de ambos os sexos e com faixa etária entre 43 a 88 anos de idade. Utilizou-se o Excel, IBM® SPSS 21.0, teste Qui-Quadrado ou teste Exato de Fisher para análise. Resultados: Na admissão, a hiperglicemia (glicemia superior a 180 mg/dL) estava presente em 75% dos pacientes que faleceram (p=0,034). Observou-se que todos os pacientes que evoluíram para óbito tinham proteína C-reativa aumentada. Conclusão: A hiperglicemia da admissão correlaciona com pior prognóstico de pacientes com IAM com supradesnível do segmento ST. A proteína C-reativa apresenta uma associação com o pior prognostico, mas sem relação estatística significante devido ao tamanho da amostra.Palavras-Chave: Hiperglicemia; Proteína C; Prognóstico; Infarto do miocárdio com supradesnível do segmento STABSTRACTIntroduction: Patients with Acute Myocardial Infarction (AMI) present an intense systemic response to ischemic injury and may develop complications that may be associated with the values of glycemia and C-reactive protein when they were admitted to hospital. Aims: To evaluate the relationship of glycemic and C-reactive protein levels with the prognosis of hospitalized patients with ST-elevation myocardial infarction. Methods: Retrospective and cross-sectional study with medical records of hospitalized patients with a diagnosis of AMI with ST segment elevation in the period from March 1, 2016 to February 28, 2017, at Hospital Escola de Itajubá (Brazil). The analysis included 71 patients of both genders and ages between 43 and 88 years old. It was used Excel, IBM® SPSS 21.0, Chi-Square test or Fisher's Exact test for the analysis. Results: At admission, hyperglycemia (glycemia greater than 180 mg/dL) was present in 75% of patients who died (p=0,034). It was observed that all patients who evolved to death in study had an increased C-reactive protein levels. Conclusion: Admission hyperglycemia is correlated with worse prognosis in patients with AMI with ST segment elevation. C-reactive protein had an association with the worst prognosis, but there was no statistically significant relationship due to the sample size.Keywords: Hyperglycemia; C-reactive protein; Prognosis; AMI with ST segment elevation

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“…The atherosclerosis in diabetics is more severe, appears with greater frequency, and occurs earlier when compared with healthy individuals, increasing the risk of cardiac infarction in those diabetic individuals [6].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Associated to Atherosclerosis Risk Factors in Patients of Family Health Unity

Alves¹,

Pereira²,

Letti³

et al. 2015

OJPM

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Cardiovascular diseases, including atherosclerosis, are important causes of death among diabetics. Features of diabetes mellitus (DM) associated with atherogenic risk factors are discussed by a cross-sectional study. It was evaluated 432 families attended by Basic Family Health Unities (FHU), registered at Family Health Program (HIPERDIA) at borough Alto da Maravilha in Senhor do Bonfim, Bahia, Brazil. Among eligible patients, 50 (8.4% of the total) were included in diabetic group (DB), and 80 (9.4% of the total) in the non-diabetic group (NDB). The majority was women (90/ 130) in the age range 48 -77. The diabetic group showed a high prevalence among analyzed variables, such as hypertension (74.0%) and obesity (46.0%). Significant differences were not found among lipoprotein cholesterol concentrations comparing the DB and NDB groups. The correlation analysis showed significant differences among LDL-C-DB and CT-DB (p < 0.0001), LDL-NDB and CT-NDB (p < 0.0001), LDL-NDB and TG-NDB (p = 0.0034), and CT-NDB and TG-NDB (p = 0.0001). Diabetic and healthy individuals do not present significant differences in the lipid profiles. By the way, the diabetic and health individuals can not present significant differences in the lipid profile, however, probably there are differences in the quality of the lipoprotein molecules between DB and NDB and a divergent tendency of the disease progression, such as a higher disposition to atherosclerosis development in DB. These patients with potential risk to development atherosclerosis or aggravation of diabetes must have more attention about Family Health Program.

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Hiperglicemia e doença cardiovascular podem coexistir

Cited by 6 publications

References 9 publications

Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus

Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus

Relação dos níveis de glicemia e proteína C-reativa com o prognóstico de pacientes com infarto agudo do miocárdio com supradesnível do segmento ST / Relation of blood glucose and C-reactive protein levels to the prognosis of patients with acute myocardial infarction with ST segment elevation

Diabetes Associated to Atherosclerosis Risk Factors in Patients of Family Health Unity

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