Disfunção autonômica cardiovascular no diabetes mellitus experimental

Angelis, Kátia De; Schaan, Beatriz D’Agord; Rodrigues, Bruno; Malfitano, Christiane; Irigoyen, Maria Cláudia

doi:10.1590/s0004-27302007000200007

Cited by 6 publications

(4 citation statements)

References 85 publications

(113 reference statements)

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“…20,23 Furthermore, the hyperglycaemia could have been responsible for the higher values found for LA in the saline and PD groups ( Table 2), as LA has been implicated as the main factor responsible for the chronicity of cutaneous lesions in diabetic humans and in rodents treated with STZ. 23,33,[35][36][37]…”

Section: Time (Days)mentioning

confidence: 99%

Role of autologous mesenchymal stem cells associated with platelet-rich plasma on healing of cutaneous wounds in diabetic mice

Neto

Carlo

Monteiro

et al. 2012

Clinical and Experimental Dermatology

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Section: Time (Days)mentioning

confidence: 99%

Role of autologous mesenchymal stem cells associated with platelet-rich plasma on healing of cutaneous wounds in diabetic mice

Neto

Carlo

Monteiro

et al. 2012

Clinical and Experimental Dermatology

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“…Studies with experimental models have shown that the chemoreflex is decreased 29 . In humans, it has been observed a decrease in the peripheral chemoreflex in individuals with type 2 diabetes, especially regarding the response to hypoxia 30 .…”

Section: Chemoreflexes and Ventilatory Abnormalitiesmentioning

confidence: 99%

Comportamento dos quimiorreflexos central e periférico na insuficiência cardíaca

Guimarães¹,

Belli²,

Bacal

et al. 2011

Arq. Bras. Cardiol.

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alterations result in systolic and/or diastolic dysfunction and, consequently, in the loss of functional capacity, decrease in quality of life and increased morbidity and mortality 3,4 .The HF syndrome is associated with hemodynamic disorders followed by systemic alterations, endothelial dysfunction, neurohormonal activation with increased catecholamine release, higher brain natriuretic peptide (BNP) levels 5 and release of pro-inflammatory factors that contribute to heart dilation and poorer performance at physical exercises 5,6 . Patients with HF present higher levels of ventilation for a certain workload when compared to normal individuals 7 . This fact results in low ventilatory efficiency and is related with higher ventilation related to CO 2 production, which is an important predictor of poor prognosis, in addition to being a limiting factor for the practice of exercises 8,9

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“…[ 10 – 12 ] Therefore, it is understood that studies on the behavior of blood pressure (BP), and heart rate (HR), as well as the autonomic control of circulation and glycemic control in diabetic individuals, may contribute to the understanding of the pathophysiological mechanisms involved. [ 13 ]…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory parameters and glycated hemoglobin of patients with type 2 diabetes after a rehabilitation program

et al. 2018

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Introduction:Cardiovascular autonomic dysfunction reflex of the pathophysiology of diabetes mellitus (DM) favors an increase in morbidity and mortality related to cardiovascular events, and for this reason has been one of the most studied clinical entities.Method:An experimental study of a randomized clinical trial type was therefore proposed to analyze the hemodynamic and glycemic response after the practice of a rehabilitation program in patients with type 2 diabetes mellitus (T2DM). In this clinical trial the patients will initially be submitted to an evaluation protocol that consists of assessing blood pressure, heart rate, Borg scale, respiratory rate, oxygen saturation, distance traveled through the 6-minute walk test, quality of life questionnaire, Pittsburgh sleep quality questionnaire, and still glycated hemoglobin and heart rate variability through the cardiofrequency meter. After careful evaluation of the patients, they will be submitted to a metabolic rehabilitation program composed of aerobic and resisted exercises, performed for 12 weeks, in 3 weekly meetings of 60 minutes each. With such evaluations, it will be possible to construct with evidence that it is possible to work safer metabolic rehabilitation programs in patients with T2DM or other diseases that generate cardiovascular risks, guaranteeing them an improvement in cardiorespiratory fitness, hemodynamic and glycemic variables, allowing improvement of the quality of life.Ethics and Dissemination:The protocol is approved by the host institution's ethics committee under the number 1.616.721. Results will be disseminated via peer-reviewed journal articles and conferences. This clinical trial is registered at ClinicalTrials.gov identifier: NCT3094767.

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Disfunção autonômica cardiovascular no diabetes mellitus experimental

Cited by 6 publications

References 85 publications

Role of autologous mesenchymal stem cells associated with platelet-rich plasma on healing of cutaneous wounds in diabetic mice

Role of autologous mesenchymal stem cells associated with platelet-rich plasma on healing of cutaneous wounds in diabetic mice

Comportamento dos quimiorreflexos central e periférico na insuficiência cardíaca

Cardiorespiratory parameters and glycated hemoglobin of patients with type 2 diabetes after a rehabilitation program

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