Hipotireoidismo Congênito Como Fator De Risco Para Os Transtornos Do Processamento Auditivo Central

Andrade, Caio Leônidas Oliveira de; Lemos, Aline Cupertino; Machado, Gabriela Carvalho; Fernandes, Luciene da Cruz; Silva, Lais Luz; Oliveira, Hélida Braga de; Ramos, Helton Estrela; Alves, Crésio

doi:10.1590/1984-0462/;2019;37;1;00014

Cited by 8 publications

(5 citation statements)

References 24 publications

(28 reference statements)

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“…The reason for the increased acoustic reflex sensation level, or even the absence of this sensation in conditions of intact middle ear and normal tonal hearing thresholds with the presence of otoacoustic emissions, suggest signs of retrocochlear changes. The importance of early treatment of CH is highlighted for benefits not only to hearing acuity, but also to other subclinical hearing disorders ( Hébert et al., 1986 ; Heyerdahl and Oerbeck., 2003 ; Andrade et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…Authors ( Andrade et al., 2019 ) have ratified the existence of subclinical auditory findings in individuals with HC, and that these are fundamental in the early targeting of linguistic and behavioral assessments of children. Therefore, the triad is necessary: early diagnosis of CH, regular monitoring of clinical conditions and health promotion strategies to improve not only treatment adherence but the prognosis of long-term hearing disorders ( Léger et al., 2014 , 2015 ).…”

Section: Discussionmentioning

confidence: 99%

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Congenital hypothyroidism as a risk factor for hearing and parents’ knowledge about its impact on hearing

et al. 2021

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Aim To evaluate the hearing of children with congenital hypothyroidism (CH) and to analyze the knowledge that parents’ have on the possible auditory impacts of the disease. Methods A total of 263 parents/guardians were interviewed about aspects of CH and hearing. Audiological evaluation was performed on 80 participants, divided into two groups: with CH (n= 50) and without CH (n=30). Clinical and laboratory CH data were obtained from medical records, pure tone auditory thresholds and acoustic reflexes were analyzed. The auditory data was compared between groups. Student’s t-test and Chi-square were used for statistical analysis at a significance level of 5% (p ≤0.05). Results The majority (78%), of the parents were unaware that CH when not treated early is a potential risk to hearing. There was no correlation between socioeconomic class and level of information about CH and hearing (p>0,05; p=0.026). There was a statistically significant difference between the auditory tone thresholds of the groups and between the levels of intensity necessary for the triggering of the acoustic reflex. The group with CH presented the worst results (p≤0.05) and absence of acoustic reflex in a normal tympanometric condition. Conclusions Children with CH are more likely to develop damage to the auditory system involving retrocochlear structures when compared to healthy children, and that the disease may have been a risk factor for functional deficits without deteriorating hearing sensitivity. The possible impacts of CH on hearing, when not treated early, should be more publicized among the parents/guardians of this population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Congenital hypothyroidism as a risk factor for hearing and parents’ knowledge about its impact on hearing

et al. 2021

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“…This suggests that auditory pathway changes may be already present at birth. Another study conducted with 112 CH patients older than five years of age demonstrated more frequent changes in cognitive functions, such as auditory attention, figure-background ability, and auditory memory, all related to central auditory processing [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns

et al. 2021

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Objective This study aimed to look for a possible relationship between thyrotropin (TSH) values from neonatal bloodspot screening testing and newborn lower auditory pathway myelinization evaluated using the brainstem evoked response audiometry (ABR) test. Methods Sixty-two healthy full-term newborns without perinatal problems were enrolled in the study. TSH results were collected from neonatal bloodspot screening data and were below the test cut-off level (15μUI/mL). The TSH test was performed between three and seven days, and the ABR test was performed in the first 28 days of life. The newborns were divided into two groups: Group 1 (n = 35), TSH between 0 and 5μUI/mL, and group 2 (n = 27), TSH between 5 and 15μUI/mL. Data are presented as mean ± SD, median, or percentage, depending on the variable. Results Wave latency and interpeak interval values for Groups 1 and 2 were as follows: Wave I: 1.8 ± 0.1 and 1.7 ± 0.1; Wave III: 4.4 ± 0.1 and 4.4 ± 0.1; Wave V: 6.9 ± 0.1 and 6.9 ± 0.1; interval I–III: 2.6 ± 0.1 and 2.6 ± 0.1; interval I–V: 5.1 ± 0.1 and 5.1 ± 0.1; interval III–V: 2.4 ± 0.1 and 2.4 ± 0.1. There were no significant differences in ABR parameters between groups 1 and 2 (p > 0.05). Multiple regression analysis showed a slight significant negative correlation between TSH and wave I values (standardized β = −0.267; p = 0.036), without observing any relationship with the other ABR waves recorded. Conclusions This study investigated the relationship of TSH and auditory myelinization evaluated by ABR. It did not show a significant change in lower auditory pathway myelinization according to TSH levels in newborns with TSH screening levels lower than 15 μUI/mL.

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“…Increased sleep and decreased activity, feeding difficulty, constipation, and prolonged jaundice are common symptoms of children with CH ( 4 , 5 ). According to new evidence, CH can be a risk factor for central hearing process disorders ( 6 ). This endocrine disorder can be detected on newborn screening, and infants who are identified in the first month have the best prognosis for optimal mental development ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…a Population attributable fraction (PAF) calculated using the Miettinen's equation and approximated for the case-control study 6. Int J Endocrinol Metab.…”

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confidence: 99%

Familial-Related Risks for Congenital Hypothyroidism in Iranian Newborns: A Population-Based Case-Control Study

Yarahmadi

Azhang

Salesi

et al. 2021

Int J Endocrinol Metab

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Background: Congenital hypothyroidism (CH), as one of the most common endocrine disorders, is a preventable cause of mental retardation. Objective: This study aimed to identify familial-related risk factors for CH in Iranian newborns. Methods: A population-based case-control study was performed on the National Registry System of patients with CH in Iran. In this study, 906 controls and 454 cases were studied for one year. Familial related factors were investigated using logistic regression models. Population attributable fraction (PAF) was also calculated for each significant risk factor. Results: Using multivariate analysis, an increased risk for CH was observed in patients with congenital anomalies (odds ratio (OR): 5.77, 95% confidence interval (CI): 2.37 - 14.01), history of mental retardation in family (OR:2.10, 95% CI: 1.15-3.83), mother’s hypothyroidism during pregnancy (OR: 2.01, 95% CI: 1.33 - 3.03), intra-family marriage (OR:1.49, 95% CI: 1.18 - 1.89), gestational diabetes (OR: 1.69, 95% CI: 1.09 - 2.63), having a hypothyroid child in the family (OR: 2.48, 95% CI: 1.39 - 4.42), and twins or more (OR: 2.61, 95% CI: 1.31 - 5.21). The highest PAF among familial-related risk factors for CH is related to the intra-family marriage (14.9%). Conclusions: This study revealed that familial-related risk factors and consanguine marriages play an essential role in the high incidence of CH in Iran. About 15% of CH in Iran could be attributed to intra-family marriage alone.

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Hipotireoidismo Congênito Como Fator De Risco Para Os Transtornos Do Processamento Auditivo Central

Abstract: The data obtained show a high frequency of lag symptoms in cognitive functions related to central auditory processing, particularly with regard to auditory attention, figure-background ability and auditory memory in patients with congenital hypothyroidism.

Cited by 8 publications

References 24 publications

Congenital hypothyroidism as a risk factor for hearing and parents’ knowledge about its impact on hearing

Congenital hypothyroidism as a risk factor for hearing and parents’ knowledge about its impact on hearing

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns

Familial-Related Risks for Congenital Hypothyroidism in Iranian Newborns: A Population-Based Case-Control Study

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