Identificação das espécies de Candida em portadores de estomatite protética e avaliação da susceptibilidade ao miconazol e à terapia fotodinâmica

Leite, Danielle Prado; Piva, Marta Rabello; Martins-Filho, Paulo Ricardo

doi:10.1590/1807-2577.1027

Cited by 16 publications

(20 citation statements)

References 22 publications

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“…Regarding the prevalence of species, our findings corroborate studies that showed Candida albicans as the primary etiological agent of denture stomatitis [2, 21, 27, 36, 47–49]. …”

Section: Discussionsupporting

confidence: 89%

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Pina

Lia

Berretta

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation of Brazilian propolis extract compared to miconazole oral gel for the treatment of denture stomatitis due to Candida spp. infection in older adults. Forty patients were randomly allocated in a noninferiority clinical trial into two groups. The control group (MIC) received 20 mg/g miconazole oral gel and the study group (PROP) received mucoadhesive formulation containing standardized extract of 2% (20 mg/g) propolis (EPP-AF®) during 14 days. Patients were examined on days 1, 7, and 14. The Newton's score was used to classify the severity of denture stomatitis. The colony forming unity count (CFU/mL) was quantified and identified (CHROMagar Candida®) before and after the treatment. Baseline characteristics did not differ between groups. Both treatments reduced Newton's score (P < 0.0001), indicating a clinical improvement of the symptoms of candidiasis with a clinical cure rate of 70%. The microbiological cure with significant reduction in fungal burden on T14 was 70% in the miconazole group and 25% in the EPP-AF group. The EPP-AF appears to be noninferior to miconazole considering the clinical cure rate and could be recommended as an alternative treatment in older patients.

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“…Regarding the prevalence of species, our findings corroborate studies that showed Candida albicans as the primary etiological agent of denture stomatitis [2, 21, 27, 36, 47–49]. …”

Section: Discussionsupporting

confidence: 89%

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Pina

Lia

Berretta

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Abundant fungal structures are observed in specimens obtained from the surface of complete removable dental prostheses. This fact allows us to infer that inadequate use of prostheses, together with inadequate hygienization favor the growth of genus Candida yeasts, particularly C. albicans 9 , 10 , 12 .…”

Section: Discussionmentioning

confidence: 99%

Factors Related to Oral Candidiasis in Elderly Users and Non-Users of Removable Dental Prostheses

Bianchi

Tadano³

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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This study examined the association between oral candidiasis in elderly users and nonusers of prosthesis and its predisposing factors. To this end, we performed a cross-sectional study where saliva samples from 48 patients were collected they used prosthesis and 43 patients (control group) who did not use. Among the 91 patients, Candida spp were isolated in 40 (83.3%) who used prosthesis and in 23 (53.5%) in the control group. A statistically significant association was determined between the two groups, the isolation of yeasts and dental prosthesis (p < 0.05, OR = 4.3). The most common etiological agent was Candida albicans (37 isolates), with 23 (62.2%) in the denture group and 14 (37.8%) (control group). Among patients who presented clinical manifestations of oral candidiasis (n = 24), 83.3% (n = 20) belonged to the group that wore dentures, while only 16.7% (n = 4) belonged to the control group. Elderly patients with diabetes had 4.4 times higher estimated risk of developing oral candidiasis when compared with individuals without this condition. There was no statistically significant association between being user prostheses and have diabetes with the onset of candidiasis. No statistically significant association was determined between xerostomia, use of prosthesis and oral candidiasis. The use of prosthetics and poor oral hygiene in elderly patients predisposes to the development of oral candidiasis.

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“…Candida albicans is the most well-known fungal species associated with the clinical manifestation of this pathology. In addition to C. albicans , other less common Candida spp., such as C. tropicalis , C. glabrata , C. parapsilosis , and C. krusei , are pathogens present in the oral microbiota that can become pathogenic [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Essential Oils against Candida albicans Strains Isolated from Users of Dental Prostheses

Freire

Júnior

Silva

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective The objective of this study was to analyze the antifungal activity of citral, selected by screening natural products, against Candida albicans isolates from subjects who use dental prostheses. Methodology Screening of essential oils, including those from Mentha piperita L. (Briq), Origanum vulgare, and Zingiber officinale L., and the phytoconstituents citral and limonene, to select an appropriate natural product. Citral, which mediated the best antifungal response, was selected for biological assays. The minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) for citral and nystatin were determined by the microdilution method. Micromorphological analyses, time-kill curve, and modulation tests were performed. Results The MIC and MFC of citral were established as 32 μg/mL, consistent with fungicidal activity. The clinical strains were resistant to nystatin. Citral caused micromorphological alteration in the strains. In the time-kill curve, the growth of the clinical strain was reduction in growth equal to 3 log10 colony-forming units per milliliter after exposure to the MIC and MIC × 2 of citral for 2 h. Citral did not modulate the resistance of the studied strains to nystatin. Conclusion This study revealed the potential of citral as a fungicidal agent and highlighted the resistance of clinical strains of C. albicans to nystatin.

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Identificação das espécies de Candida em portadores de estomatite protética e avaliação da susceptibilidade ao miconazol e à terapia fotodinâmica

Cited by 16 publications

References 22 publications

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Factors Related to Oral Candidiasis in Elderly Users and Non-Users of Removable Dental Prostheses

Antifungal Activity of Essential Oils against Candida albicans Strains Isolated from Users of Dental Prostheses

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