Our results suggest that farmers in this semiarid area have a high risk of lip cancer and indicate the need for health public programs in the early detection of AC and education to teach the population about precautions to be taken during sun exposure.

Context:Focal fibrous hyperplasia, also known as irritation or traumatic fibroma, is a reactive, inflammatory hyperplastic lesion of the connective tissue.Aim:The aim of this study is to perform a retrospective study of a focal fibrous hyperplasia of 18 years.Materials and Methods:We retrospectively reviewed 193 cases of focal fibrous hyperplasia of the oral cavity from the medical and histological reports of the Department of Oral Pathology, Pernambuco University, Brazil, during the period between January 1992 and December 2009.Settings and Design:Data with regard to age, gender, location, size of the lesion (equal to or less than 1 cm, between 1 and 2 cm and greater than 2 cm), pain, history of trauma, treatment, length of follow-up (from diagnosis to release or last review) and recurrence, were collected.Results:The most commonly affected site was the buccal mucosa (n = 119, 61.7%). Almost two-thirds of the cases were concentrated from the second to the fifth decade of life. Females were more affected than men and a history of trauma was related by 90.7% of the patients. Two recurrences were notified (1.0%).Conclusion:Further studies are needed on the distribution of the lesion in different ethnic and geographical populations. The influence of sex hormones on the development of focal fibrous hyperplasia must be clarified.

ABSTRACT

Due to the frequent presence of inflammation in cases of carcinoma and its use as a parameter for the assessment of tumor aggressiveness, the role of inflammation in oral carcinogenesis was investigated. This was performed by evaluating the expression of cellular markers, cytokines and nuclear transcription factors that identify the cells that participate in the antitumor defense in cases of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). A semi-quantitative immunohistochemical analysis was performed for the transcription factors cluster of differentiation 8 (CD8), forkhead box P3 (FOXP3), transforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α and nuclear factor κ-light chain enhancer of activated B-cells (NF-κB), in cases of OED and OSCC. CD8, TGF-β, TNF-α and NF-κB participated in the processes of tumor transformation and progression. The presence of inflammatory infiltrate in cases of OED favors the transformation and invasion process when stromal TNF-α and NF-kB are overexpressed, as NF-kB activated by TNF-α during inflammation predisposes the lesion to transformation, functioning as a link between inflammation and cancer. The control of these inflammatory mediators may prevent malignant transformation in the oral cavity.

MARTINS-FILHO SUMMARY:Oral pyogenic granuloma is a hyperplastic inflammatory lesion commonly associated to local irritation or trauma. Females are more affected than men probably due to the vascular effects of hormones that occur during puberty, pregnancy and menopause. In the pregnancy, the lesions are known as "pregnancy tumor" and tend to occur more frequently during the second and third trimester. In the oral cavity, histopathological examination is required for diagnosis, since the lesion is clinically indistinguishable from other reactive lesions and, usually, there is no evidence of bone involvement. The authors report a rare case of pyogenic granuloma with destruction of alveolar bone mimicking a malignant tumor in a 20-year-old woman in the 19 th week of pregnancy.

Miconazole gel provides better results than a protocol combining methylene blue-mediated PDT and LPL therapy in the treatment of type II denture stomatitis.

bjective: This study investigated whether some components of the extracellular matrix and CD68 expression may drive the differences between the central giant cell granuloma (CGCG) of the jaws and giant cell tumor (GCT) of long bones, which present distinct evolution and clinical behavior. Material and Methods: Eight cases of CGCG and 7 cases of GCT were selected and immunohistochemically analyzed to verify the pattern of expression of CD68, tenascin (Tn) and fibronectin (Fn). Results: A large number of the mononuclear cells and multinucleated giant cells CD68+ was observed in both of the studied lesions, indicating histiocyte/ macrophage origin. Seven cases of CGCG of the jaws showed intense staining of Fn, with uniform distribution predominantly. In all 7 cases of GCT of long bones the Fn displayed intense expression, with distribution pattern varying from uniform to reticulate/fibrillar. Six cases of CGCG were intensively stained by Tn, presenting focal expression in half of specimens, and reticulate/ fibrillar pattern of expression in 4 cases. All cases of GCT of the long bones presented intense expression of Tn, uniform distribution, and reticulate/fibrillar pattern of expression in four cases. Conclusions: The immunoexpression of CD68 in mononuclear cells and multinucleated giant cells and staining patterns of Fn and Tn were similar in both entities. These findings indicate that these proteins could not be used to explain the differences between the CGCG of the jaws and GCT of the long bones.

INTRODUÇÃO: Próteses mucossuportadas são consideradas facilitadoras, em potencial, da estomatite protética (EP), condição caracterizada pelo aspecto eritematoso, difuso ou pontilhado da mucosa palatina sob a base das próteses. A etiologia da doença é multifatorial, embora a infecção por Candida seja uma causa bastante comum. OBJETIVO: Relacionar a EP com a presença de Candida, identificar as espécies de Candida mais prevalentes, a partir do meio CHROMagar Candida(r), e caracterizar o perfil de sensibilidade das colônias ao miconazol e à terapia fotodinâmica (TFD). MATERIAL E MÉTODO: A amostra foi constituída por 45 usuários de prótese total, sendo 30 com diagnóstico clínico de EP e 15 sem a doença. Realizou-se raspagem com swab da mucosa palatina e das próteses, e as amostras foram semeadas em CHROMagar Candida(r), para identificação de espécies de C. albicans, C. krusei e C. tropicalis. Após incubação e leitura das placas, as colônias foram reisoladas em Ágar Sabouraud, para caracterização da sensibilidade ao miconazol e à TFD. RESULTADO: Espécies de Candida estiveram presentes em 53,33% das amostras dos pacientes com EP e em 6,67% das amostras dos pacientes sem EP, considerando-se o total de amostras de mucosa (p=0,008) e próteses (p=0,001). As espécies mais prevalentes foram C. albicans (36,67% e 53,33%), seguida de C. tropicalis (13,33% e 16,67%) e C. krusei (13,33% e 6,67%), em mucosa e prótese, respectivamente. As amostras mostraram maior sensibilidade ao miconazol que à TFD (p<0,0001). CONCLUSÃO: Existiu uma associação entre a presença de Candida e EP, sendo C. albicans a espécie mais prevalente. Miconazol proveu melhores resultados na eliminação in vitro de colônias de Candida quando comparado à TFD.