Methylene Blue‐Mediated Photodynamic Inactivation Followed by Low‐Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis

Maciel, Carolina Menezes; Piva, Marta Rabello; Ribeiro, Maria Amália Gonzaga; Santos, Thiago de Santana; Ribeiro, Cyntia Ferreira; Martins-Filho, Paulo Ricardo

doi:10.1111/jopr.12284

Cited by 25 publications

(17 citation statements)

References 33 publications

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“…In a systematic review, Javed et al 2 reported that only three clinical investigations are available describing PDT as a treatment modality of oral candidiasis. One of these studies, a clinical report, 3 was cited by Maciel et al 1 However, two clinical trials published in 2012 employed PDT for the treatment of this fungal infection. 4,5 In one study 20 patients with denture stomatitis had their palate and dentures treated with PDT employing a hematoporphyrin derivative (Photogem; Photogem LLC Co, Moscow, Russia) and a light-emitting diode (LED) device.…”

Section: Dear Editormentioning

confidence: 99%

“…In a systematic review, Javed et al reported that only three clinical investigations are available describing PDT as a treatment modality of oral candidiasis. One of these studies, a clinical report, was cited by Maciel et al . However, two clinical trials published in 2012 employed PDT for the treatment of this fungal infection .…”

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confidence: 96%

“…The paper recently published by the Journal of Prosthodontics entitled “Methylene Blue‐Mediated Photodynamic Inactivation Followed by Low‐Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis” by Maciel et al mentioned in its abstract that “photodynamic therapy (PDT) appears to be an effective method for the in vitro and in vivo inactivation of Candida spp., but no clinical trials in this context have yet been conducted.”…”

mentioning

confidence: 99%

“…for treating oral candidosis. Nonetheless, the recently published investigation of Maciel et al did not mention the clinical studies available in the literature, limiting the originality of their investigation.…”

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confidence: 99%

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Comments on “Methylene Blue‐Mediated Photodynamic Inactivation Followed by Low‐Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis”

Mima

2016

Journal of Prosthodontics

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confidence: 96%

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Comments on “Methylene Blue‐Mediated Photodynamic Inactivation Followed by Low‐Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis”

Mima

2016

Journal of Prosthodontics

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“…[50][51][52][53] Methylene blue, toluidine blue and porphyrin derivatives have been the most commonly used photosensitizers. 10,[51][52][53] Nanomaterials have also been used in the treatment of denture stomatitis. Acosta-Torres et al 9 developed poly(methyl methacrylate)-silver nanoparticle discs to prevent/treat denture stomatitis.…”

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confidence: 99%

Tratamento da estomatite protética: revisão de literatura

Martins

Gontijo

2017

Rev. Bras. Odontol.

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Objective: this study aimed to investigate the main therapeutic options for denture stomatitis in patients using complete removable prostheses, to determine the best treatment method, avoiding relapses and improving patients' quality of life. Material and Methods: a search was made in the databases and electronic search tools PubMed, LILACS, SciELO and Web of Science using keywords, in Portuguese and English, such as denture stomatitis, Candida albicans, antifungal, oral candidiasis, and treatment. Results: studies have shown that the main drugs used in the treatment of denture stomatitis are miconazole, fluconazole, itraconazole, nystatin, amphotericin B, ketoconazole, clotrimazole and chlorhexidine. Regardless of the treatment employed, there is an improvement in the disease's clinical symptoms, but it does not prevent recolonization of the oral mucosa in patients with poor hygiene of the dental prosthesis. Conclusion: it is not possible to determine the best therapy for denture stomatitis, since the studies evaluated showed drug efficacy, but with relapses, especially in patients with poor hygiene of the dental prosthesis.

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Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis

Roomaney

Holmes

Engel

2021

Clinical & Exp Dental Res

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Objectives This systematic review evaluated the evidence for the effectiveness of Photodynamic therapy (PDT) in treating oral fungal infections, as an alternative to conventional antifungal medications. Methods Five randomized control trials (168 participants) comparing the treatment of oral fungal infections using met with our inclusion criteria. Clinical and microbiological improvement was assessed by random‐effects meta‐analysis. Methodological quality assessment and heterogeneity were performed using peer‐reviewed criteria. PROSPERO registration: CRD42017076. Results PDT showed statistically non‐significant increased clinical efficacy (risk ratio (RR) = 1.47 [95% confidence interval (CI), 0.68; 3.17]; three studies, n = 108 participants, I2 = 50%) and mycological efficacy (mean difference (MD) = 0.54 [95%CI, −0.71; 1.79]; three studies, n = 100; I2 = 39%) at 30 days, as compared with conventional antifungal therapy. Lack of standardization of treatment parameters and variability in the assessment of outcomes was observed across the studies. All included studies had a moderate to low risk of bias. Conclusions PDT showed comparable effectiveness at treating oral fungal infections, particularly denture stomatitis. The small number of studies in this review, small sample size and variability of methods and outcome measures across studies, highlight the need for more standardized studies with longer follow‐up periods to enable recommendation of PDT as an alternative to conventional antifungal therapy.

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Methylene Blue‐Mediated Photodynamic Inactivation Followed by Low‐Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis

Abstract: Miconazole gel provides better results than a protocol combining methylene blue-mediated PDT and LPL therapy in the treatment of type II denture stomatitis.

Cited by 25 publications

References 33 publications

Comments on “Methylene Blue‐Mediated Photodynamic Inactivation Followed by Low‐Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis”

Comments on “Methylene Blue‐Mediated Photodynamic Inactivation Followed by Low‐Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis”

Tratamento da estomatite protética: revisão de literatura

Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis

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