Effect of astaxanthin and fish oil on enzymatic antioxidant system and ?-amylase activity of salivary glands from rats

Leite, Mariana Ferreira; Lima, Amanda Martins de; Kang, Simone Jee Sun; Santos, Maria Teresa Botti Rodrigues; Otton, Rosemari

doi:10.1590/1677-3225v13n1a12

Cited by 10 publications

(4 citation statements)

References 34 publications

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“…Leite et al (2014) 35 suggested that there are reduced risks of inflammatory disease in patients who have a polyunsaturated fatty acid (PUFAs) rich diet. PUFAs could be related with an increment of salivary amylase.…”

Section: Icmentioning

confidence: 99%

Chemical salivary composition and its relationship with periodontal disease and dental calculus

Hernández-Castañeda

Moya

Mora³

et al. 2015

Braz. J. Oral Sci.

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Aim: To determine the relationship between the chemical composition of saliva, periodontal disease and dental calculus. Methods: An observational analytical cross-sectional study was conducted with patients over 55 years of age. Ethical principles of autonomy and risk protection were applied according to the international standards. Sociodemographic and diagnosis variables (presence of dental calculus and periodontal status) were considered to measure salivary concentrations of glucose (by the glucose oxidase/peroxidase method, amylase (by the colorimetric test), urea (by the amount of indophenol), total protein (by the Bradford method) and albumin (by the nephelometric method). Patients chewed a sterile rubber band and 3 mL of stimulated saliva were collected. The samples were stored at-5 °C, centrifuged at 2,800 rpm for 10 min, and the supernatant was removed and stored at-20 °C. Data were presented as frequencies and proportions for qualitative variables and measures of central tendency and dispersion for quantitative variables. Data were analyzed by either analysis of variance or Kruskal Wallis test. A p value <0.05 was considered statistically significant. Results: Significant relationships were observed between the concentration of salivary urea and periodontal status (p = 0.03) and the presence of dental calculus and urea (p = 0.04) was demonstrated. Conclusions: A relationship between the salivary urea concentration and the presence of periodontal disease and dental calculus is suggested.

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Section: Icmentioning

confidence: 99%

Chemical salivary composition and its relationship with periodontal disease and dental calculus

Hernández-Castañeda

Moya

Mora³

et al. 2015

Braz. J. Oral Sci.

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“…Cells of the acini and duct system showed a relatively normal structure compared to the PTU treated group (B). The antioxidant effect of fish oil has a great impact on its beneficial influence on parotid gland (37) . According to Usch et al (38) parotid gland responded positively to treatment with antioxidants showing increased amylase activity.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that populations ingesting PUFAs in large amounts, mainly found in fish oil, the risk of neurodegenerative disorders such as Alzheimer's disease is reduced. Also, the reduced incidence of acute myocardial infarction and chronic inflammatory diseases such as rheumatoid arthritis, ulcerative colitis, psoriasis, among other inflammatory diseases has been noted (11) . As an important antioxidant, PUFAs regulate the antioxidant signaling pathways when incorporated in the cell membranes.…”

Section: Introductionmentioning

confidence: 99%

Possible Protective Effect of Fish Oil on Parotid Salivary Glands in Adult Male Albino Rats With Ptu - Induced Hypothyrodism (Histological and Ultrastructural Study)

Hamza

ElKazzaz

2022

Egyptian Dental Journal

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Introduction: Propylthiouracil is used to treat hyperthyroidism and to induce the hypothyroidism in experimental animals. Hypothyroidism has a negative impact on many body organs. However, few studies were done to evaluate the effect of hypothyroidism on parotid glands. Fish oil has an important antioxidant and anti-inflammatory properties.Aim: This study aimed to investigate the effect of Propylthiouracil induced hypothyroidism on the histological and ultrastructure features of parotid glands of rats and the possible prophylactic effect of fish oil.Materials and Methods: 30 adult male albino rats were divided equally into 3 groups. Control group (A), hypothyroidism induced group (B) and hypothyroidism induced + fish oil group (C). Hypothyroidism was induced in group (B) and (C)using 10 mg / kg body weight Propylthiouracil. For group (C), fish oil was given with Propylthiouracil as 0.5ml/100gm body weight daily for 28 days. At the end of the study the parotid glands were harvested and prepared for histological and ultrastructure examination. Results:In group (B) the acinar cells illustrated signs of cytotoxicity including cytoplasmic vacuolations, separation between acini, dilated ducts with abnormal epithelial lining. Moreover, the ultrastructure results revealed shrunken nuclei, swelling in the rough endoplasmic reticulum, and scattered apoptotic bodies. Relative improvements in these features have been noticed in the fish oil treated group (group C). Conclusion:Hypothyroidism represents an important risk factor for parotid salivary gland dysfunction. Fish oil may have significant protective capacity not only to improve salivary glands structure, but also to help in prophylaxis against hypothyroidism.

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“…The authors added that these changes occurred in response to noxious agents and ended with mitochondrial damage due to the peroxides resulting from the reaction of fatty acids in the phospholipid bilayer of acinar and ductal cell membranes with free radicals. This finally gave rise to the insult of cellular membranes which in turn stimulates inflammatory cells migration and initiation of apoptosis [26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

Extra Hepatic Effects of Sofosbuvir on a Serous Model of Major and Minor Salivary Glands in Albino Rats

Saad

Aboushady

Mehanni

2019

Egyptian Journal of Histology

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Background: Extra hepatic adverse effects associated with the therapy of chronic HCV infection with sofosbuvir treatment regimens have recently arisen. Objective: This study aimed to assess the inflammatory effect of sofosbuvir and its influence on cellular proliferation, functionality and differentiation of both submandibular (SMGs) and Von Ebner's salivary glands (EGs). Methodology: 21 adult male albino rats were divided into three equal groups: GroupI (control) received orally distilled water; GroupII received orally sofosbuvir (40 mg/kg/day) dissolved in distilled water for one month and GroupIII received sofosbuvir for 2 months. SMGs and EGs sections were processed for H&E, immunohistochemical (using anti-COX-2 and anti-PCNA antibodies) and immunofluorescence (using anti α-amylase antibody) examination. Results: Compared to control group, groupII displayed atrophic changes in SMGs and EGs which were accentuated in groupIII; shrunken acini, glandular cell vacuolization, nuclear degenerative signs, wide degenerative stromal areas and flattening of excretory ductal lining with stagnant secretion as well as the transformation of few serous glandular cells into mucous-like cells particularly in SMGs of groupIII. Likewise, both glands of groupIІ showed significantly increased immunoreactivity to COX-2 in acini and some ductal cells but with a significant decrease in those of groupIII. Regarding PCNA immunoreactivity and α-amylase immunofluorescence, significantly diminished positivity in the glandular cells of both glands in groupII was detected compared to control group whilst insignificant improvement was elucidated in those of groupIII comparing to groupII except for the significant reactivity to α-amylase in EGs of groupIII. Conclusions: It was concluded that the oxidative stress associated degenerative changes caused by sofosbuvir in salivary glands after one month of administration seemed to be diminished after two months of administration due to the body acquired drug tolerance to restore the disturbed physiological processes. Hence, the use of anti-oxidants as an adjuvant treatment could be beneficial.

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Effect of astaxanthin and fish oil on enzymatic antioxidant system and ?-amylase activity of salivary glands from rats

Cited by 10 publications

References 34 publications

Chemical salivary composition and its relationship with periodontal disease and dental calculus

Chemical salivary composition and its relationship with periodontal disease and dental calculus

Possible Protective Effect of Fish Oil on Parotid Salivary Glands in Adult Male Albino Rats With Ptu - Induced Hypothyrodism (Histological and Ultrastructural Study)

Extra Hepatic Effects of Sofosbuvir on a Serous Model of Major and Minor Salivary Glands in Albino Rats

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