Introduction: Increasing consumption of sweetened carbonated beverages as Coca-Cola has increased dramatically lately. Many detrimental effects have been proven concerning several medical conditions such as obesity, diabetes, inflammation and osteoporosis. Quercetin, is a potent anti-oxidant that is capable of protecting variable organs such as bone against oxidative stress. Aim:This study aimed at evaluating the effect of Coca-Cola consumption on the structure of the alveolar bone in adult rats as well as the possible protective effect of Quercetin.Materials and Methods: 30 rats were randomly distributed into three equal groups. Control group I, Coca-Cola group II and Coca-Cola + Quercetin group III. The rats in groups II and III received 2 ml Coca-Cola for three consecutive months. Group (III) received 100mg/kg Quercetin throughout the experimental period. After the experimental period, rats were euthanized and the specimens were dissected and processed for histological, ultrastructural evaluation using SEM, and EDX. Results:The light microscopic results of Coca-Cola group, revealed irregular bone surface with multiple Hawship's lacunae some of which contain osteoclasts. This was accompanied with widening in PDL thickness and thinning of the bone trabecuae. However, group III, revealed smoother alveolar bone surface accompanied by normal thickness of bone trabeculae with parallel resting lines. These results were confirmed by the SEM and EDX results.Conclusions: Quercetin has a potential protective effect on Coca-Cola-induced hazards on alveolar bone by relative restoration of the normal bone architecture.
Introduction: Propylthiouracil is used to treat hyperthyroidism and to induce the hypothyroidism in experimental animals. Hypothyroidism has a negative impact on many body organs. However, few studies were done to evaluate the effect of hypothyroidism on parotid glands. Fish oil has an important antioxidant and anti-inflammatory properties.Aim: This study aimed to investigate the effect of Propylthiouracil induced hypothyroidism on the histological and ultrastructure features of parotid glands of rats and the possible prophylactic effect of fish oil.Materials and Methods: 30 adult male albino rats were divided equally into 3 groups. Control group (A), hypothyroidism induced group (B) and hypothyroidism induced + fish oil group (C). Hypothyroidism was induced in group (B) and (C)using 10 mg / kg body weight Propylthiouracil. For group (C), fish oil was given with Propylthiouracil as 0.5ml/100gm body weight daily for 28 days. At the end of the study the parotid glands were harvested and prepared for histological and ultrastructure examination. Results:In group (B) the acinar cells illustrated signs of cytotoxicity including cytoplasmic vacuolations, separation between acini, dilated ducts with abnormal epithelial lining. Moreover, the ultrastructure results revealed shrunken nuclei, swelling in the rough endoplasmic reticulum, and scattered apoptotic bodies. Relative improvements in these features have been noticed in the fish oil treated group (group C). Conclusion:Hypothyroidism represents an important risk factor for parotid salivary gland dysfunction. Fish oil may have significant protective capacity not only to improve salivary glands structure, but also to help in prophylaxis against hypothyroidism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.