Hemoglobinopathies in newborns in the southern region of the Triângulo Mineiro, Brazil. Cross-sectional study

ObjectiveTo evaluate the incidence of variant hemoglobins in different health regions.MethodsA descriptive, observational, and cross-sectional study with a quantitative approach based on secondary data in the internal records of the neonatal screening service - Laboratório Central de Saúde Pública do Estado do Piauí (PI, Brazil). The variables related to sex, ethnicity and positive diagnosis for variant hemoglobins were analyzed, with further population distribution of hemoglobinopathies among the macroregions of the state.ResultsA total of 69,180 samples of newborns were analyzed, and 3,747 were diagnosed as hemoglobinopathies, from February 1st, 2014 and December 31st, 2015. Sickle cell trait was the most frequent (4.1%), followed by hemoglobinopathy C in 0.9%; homozygous hemoglobin S cases 0.1% stood out and there were no cases of hemoglobinopathy D in the state. It is also worth noting that the highest frequencies of hemoglobin alterations in Piauí were in males (49.8%) and of parda skin color (38.5%). The region of Piauí presenting the highest incidence of heteroygous variant hemoglobins was Tabuleiros do Alto Parnaíba and Vale do Sambito, due to importance of the region's population Entre Rios.ConclusionNeonatal screening programs are important for screening, orientations regarding health actions and monitoring of families with hemoglobinopathies, in order to reduce morbidity and mortality rates.

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“…Among the newborns diagnosed, the majority (50.1%) was male and presented with the sickle cell disease in homozygosis (FS). ( 21 , 22 )…”

Section: Discussionmentioning

confidence: 99%

Incidence of variant hemoglobins in newborns attended by a public health laboratory

Reis

Branco

Conceição

et al. 2018

Einstein (São Paulo)

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“…Frequencies in Brazil vary greatly depending on the study region and the degree of ethnic mixture of the population [8].…”

Section: Introductionmentioning

confidence: 99%

“…The diagnosis of α-thal is usually reached by evaluating and quantifying fractions of hemoglobin by electrophoresis and by screening for deletions that affect the α-globin gene [4,7,9]. Knowledge and detection of blood donor candidates with these genetic alterations are extremely important for public health since, because of their high incidence and their chronic character with wide clinical variability, they affect the health system as a whole [7][8][9]. Failure to identify α-thal in blood donors, who are usually physically healthy individuals without great comorbidities, may cause misdiagnoses and subsequently lead to incorrect or unnecessary treatment [9,10].…”

Section: Introductionmentioning

confidence: 99%

Causes of microcytic anaemia and evaluation of conventional laboratory parameters in the differentiation of erythrocytic microcytosis in blood donors candidates

Carlos

Souza

et al. 2018

Hematology

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“…As hemoglobinopatias estão entre as doenças genéticas de grande relevância no mundo 1 . Entre elas destaca-se a doença falciforme (DF) que acomete predominantemente os afrodescendentes.…”

Section: Introductionunclassified

Hemoglobinopatias em gestantes submetidas ao teste da mãezinha na rede pública de saúde

Liberato

Oselame

Neves

2017

Revista Brasileira Ciências Da Saúde - USCS

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Introdução:As hemoglobinopatias estão entre as doenças genéticas de grande relevância no mundo. Aproximadamente 7% da população mundial apresenta algum tipo de hemoglobinopatia, e estimativas apontam que a cada ano nascem cerca de 300 a 400 mil crianças portadoras desses distúrbios. Objetivo: Descrever os diagnósticos prevalentes de hemoglobinopatias em gestantes submetidas ao Teste da Mãezinha na rede pública de saúde. Métodos: Estudo descritivo transversal com análise quantitativa dos dados. Foram avaliados 1.013 prontuários eletrônicos de gestantes vinculadas à rede de saúde pública do município de Pinhais, estado do Paraná, no período entre 25 de fevereiro de 2014 e 25 de fevereiro de 2015. Foram incluídos prontuários de gestantes do primeiro ao terceiro trimestre de gestação que realizaram o Teste da Mãezinha. Resultados: Verificou-se que 55,7% das gestantes realizaram o Teste da Mãezinha no 1º trimestre de gestação. Apenas 0,7% dos resultados do teste apresentaram traço de Hemoglobina C e 1,3% traço falciforme. Quanto a raça, nos resultados dos exames alterados (n=20), 50% eram brancos, 40% pardos e 10% negros. Dentre estas gestantes, 80% apresentaram intercorrências na gestação, sendo mais frequente a infecção do trato urinário (50%), leucorreias em geral (25%) e intercorrências durante o parto (12,5%). Conclusão: Neste estudo observou-se uma baixa prevalência de hemoglobinopatias. Recomenda-se a implantação do Teste da Mãezinha na rede de saúde pública brasileira para o diagnóstico precoce das hemoglobinopatias gestacionais.Palavras-chave: Doença da hemoglobina SC; traço falciforme; hemoglobina falciforme; anemia falciforme. Introduction:The hemoglobinopathies are among genetic diseases of great importance in the world. Approximately 7% of the global population have some kind of hemoglobinopathy, and estimates show that about 300,000 to 400,000 children affected by these disorders are born each year. Objective: To describe prevalent diagnoses of hemoglobinopathies in pregnant women submitted to the Mommy Test in the Brazilian public health network. Methods: Cross-sectional, descriptive study with quantitative analysis of the data. The sample included 1,013 electronic medical records of pregnant users of the public health network of the municipality of Pinhais, state of Paraná, Brazil, recorded between February 25 th , 2014 and February 25 th , 2015. Medical records of pregnant women undergoing up until the third quarter of pregnancy submitted to the Mommy Test were used. Results: It was observed that 55.7% of the pregnant women were submitted to the Mommy Test in their first quarter. Only 0.7% of the results of the test showed the Hemoglobin C trait, and 1.3% presented sickle cell trait. As for race, in the results that showed alterations (n=20), 50% of the women were white, 40% were brown, and 10% were black. Among these participants, 80% presented intercurrences during the pregnancy, the most frequent being urinary tract infection (50%), general leucorrhea (25%), and intercurrences during delivery (12.5...

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Hemoglobinopathies in newborns in the southern region of the Triângulo Mineiro, Brazil. Cross-sectional study

Cited by 6 publications

References 17 publications

Incidence of variant hemoglobins in newborns attended by a public health laboratory

Incidence of variant hemoglobins in newborns attended by a public health laboratory

Causes of microcytic anaemia and evaluation of conventional laboratory parameters in the differentiation of erythrocytic microcytosis in blood donors candidates

Hemoglobinopatias em gestantes submetidas ao teste da mãezinha na rede pública de saúde

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