2018
DOI: 10.1590/s1679-45082018ao4150
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Incidence of variant hemoglobins in newborns attended by a public health laboratory

Abstract: ObjectiveTo evaluate the incidence of variant hemoglobins in different health regions.MethodsA descriptive, observational, and cross-sectional study with a quantitative approach based on secondary data in the internal records of the neonatal screening service - Laboratório Central de Saúde Pública do Estado do Piauí (PI, Brazil). The variables related to sex, ethnicity and positive diagnosis for variant hemoglobins were analyzed, with further population distribution of hemoglobinopathies among the macroregions… Show more

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Cited by 6 publications
(7 citation statements)
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“…The incidence of live births with hemoglobinopathies detected by the PNTN varied widely among Brazilian states, with Hb S being the most frequent of the Hb variants. (15)(16)(17)(18) The highest incidence rates of NB with SCD occur in states with a higher concentration of Afro-descendants, such as Bahia. In the state of Mato Grosso do Sul, the incidence of SCD and sickle cell trait was 1:8,300 and 1:70, respectively.…”
Section: ❚ Resultsmentioning
confidence: 99%
“…The incidence of live births with hemoglobinopathies detected by the PNTN varied widely among Brazilian states, with Hb S being the most frequent of the Hb variants. (15)(16)(17)(18) The highest incidence rates of NB with SCD occur in states with a higher concentration of Afro-descendants, such as Bahia. In the state of Mato Grosso do Sul, the incidence of SCD and sickle cell trait was 1:8,300 and 1:70, respectively.…”
Section: ❚ Resultsmentioning
confidence: 99%
“…In the group of the patients older than 18 years of age who were analyzed with EHS and SSL, those with a history of priapism had significantly worse erections: EHS scored 2 [1][2][3] in comparison to individuals with PE (EHS=4 [3][4]; p=0.01) (Figure 3). Also, the patients who had priapism were less satisfied with their sexual life than the individuals with PE (SSL=2 [1][2]; versus 3 [3-5]; p=0.02) (Figure 4).…”
Section: ❚ Resultsmentioning
confidence: 99%
“…A projeção estatística foi de que 71,1% desses sujeitos teriam pelo menos um episódio de priapismo ao longo da vida. Pacientes adultos com episódios de priapismo (10/23) apresentaram função erétil significativamente pior Escala de Rigidez de Ereção de 2 [1][2][3]; p=0,01 e estavam menos satisfeitos com a vida sexual 3 [3][4][5]; p=0,02. Conclusão: O priapismo manifesta-se desde a infância, e episódios graves estão associados a dano cavernoso, prejuízo na qualidade da ereção e menor satisfação sexual.…”
Section: ❚ Resumounclassified
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“…Sickle cell disease is an inherited blood condition that is most common among people of African, Arabian, and Indian origin [ 1 ] that is caused by a single nucleotide mutation that substitutes glutamic acid for valine in the sixth position of the β-globin gene [ 2 ]. During hypoxic conditions, the red blood cell becomes sickled, and the resulting change in structure restricts circulation causing obstruction of the blood flow within the capillaries and early destruction of the cell [ 3 ].…”
Section: Introductionmentioning
confidence: 99%